CAS: 1198-37-4; 2,4-Dimethylquinoline

相似化合物

93-37-8 877-43-0 26190-82-9

上下游产品

4-methyl-pent-3-en-2-one aniline hydr°Chloride 4-(phenylamino)pent-3-en-2-one 1-benzoyl-2,4-dimethyl-1,2-dihydro-quinoline-2-carbonitrile 2,5-dimethyl-4-methoxyphenol Methyl-(5-hydroxy-2.4-dimethyl-phenyl)-aether H-[2]chinolyLiDene)-indane-1,3-dione2-(4-methyl-1H-[2]chinolyLiDene)-indane-1,3-dione 4-ethoxy-2,5-dimethylphenol

📜7-溴-2,4-二甲基-喹啉置于lithium体系中,用 四氢呋喃 用作溶剂,化学反应 10.0H,以100%的收率获得2,4-二甲基喹啉
参考文献:Ultrasound-Promoted Coupling Of Aryl And Heteroaryl Halides In The Presence Of Lithium Wire
标题:Ultrasound-Promoted Coupling Of Aryl And Heteroaryl Halides In The Presence Of Lithium Wire
摘要:Although Sonochemical Reactions Of Bromobenzene And Of 2-,3-And 4-Halogenopyridines With Lithium Wire In Thf Solution Yield The Expected Dimers,Considerable Dehalogenation Also occurs,As Monitored By C-13-NMR Spectroscopy. A Pathway For The Unusual Formation Of 4,4'-Bipyridyl From The 2-Halogenopyridines Is Proposed. No Dimers Were Detected From The Reactions With 2-Bromo-4-Methylquinoline And 7-Bromo-2,4-Dimethylquinoline. The Synthetic Potential Of Their Alternative Facile Sonochemical Dehalogenation Is Propounded.
Doi:10.1007/bf00809805

专利信息

专利号:US-11104702-B2
优先权日:2017-07-18
标题 :Process and intermediates for the synthesis of obeticholic acid and derivatives thereof
发明人：HERRÃ?IZ SIERRA IGNACIO; FERNÃ?NDEZ SAINZ YOLANDA; CORDOVILLA LOSADA CARLOS; PÉREZ ENCABO ALFONSO; TURIEL HERNANDEZ JOSÉ ANGEL
权利人:CRYSTAL PHARMA SAU
摘要:A process for the preparation of obeticholic acid and derivatives thereof by:(a) hydrogenation of the double bond and reductive opening of the epoxide of a compound of formula (II) or a salt or solvate thereofto obtain a compound of formula (IIIa) and/or (IIIb), or salts or solvates thereofand(b) conversion of a compound of formula (IIIa) and/or a compound of formula (IIIb), or a salt or solvate thereof, into a compound of formula (I), or a salt or solvate thereof

专利号:US-2007060558-A1
优先权日:2004-07-30
标 题 :Hybrid molecules QA where Q is an aminoquinoline and A is an antibiotic residue, the synthesis and uses thereof as antibacterial agents
发明人：SANCHEZ MURIEL; MEUNIER BERNARD
权利人:CENTRE NAT RECH SCIENT
摘要:The invention concerns an aminoquinoline-antibiotic hybrid compound of general formula (I): Q—(Y 1 ) p —(U) p —(Y 2 ) p -A: wherein Q represents an aminoquinoline, (Y 1 ) p (U) p —(Y 2 ) p″ is an optional spacer and A is an antibiotic residue. The invention enables the antibiotic residue activity to be unexpectedly enhanced.

专利号:EP-3431486-A1
优先权日:2017-07-18
标题 :Process and intermediates for the synthesis of obeticholic acid and derivatives thereof

专利号:WO-2019015914-A1
优先权日:2017-07-18
标 题 :METHODS AND INTERMEDIATES FOR THE SYNTHESIS OF OBETICHOLIC ACID AND DERIVATIVES THEREOF

专利号:US-2020165289-A1
优先权日:2017-07-18
标 题 :Process and intermediates for the synthesis of obeticholic acid and derivatives thereof

专利号:EP-3655419-A1
优先权日:2017-07-18
标题 :Process and intermediates for the synthesis of obeticholic acid and derivatives thereof