CAS: 1122-71-0; 6-Methyl-2-Pyridinemethanol

相似化合物

1122-72-1 13602-11-4 934-60-1

上下游产品

CAS号1122-72-1 6-甲基-2-吡啶甲醛 | CAS号13287-64-4 (6-甲基吡啶-2-基)甲基乙酸酯 | CAS号78539-91-0 7-甲基[1,2,3]三唑并[... | CAS号75-36-5 乙酰氯 | CAS号1073-23-0 2,6-二甲基吡啶 N-氧化物 | CAS号1195-59-1 2,6-吡啶二甲醇 | CAS号931-19-1 2-甲基吡啶-N-氧化物 | CAS号591-78-6 2-己酮 | CAS号13602-11-4 6-甲基-2-吡啶甲酸甲酯 | CAS号108-48-5 2,6-二甲基吡啶 | CAS号3099-29-4 2-氯甲基-6-甲基吡啶 | CAS号1122-72-1 6-甲基-2-吡啶甲醛 | CAS号934-60-1 6-甲基-2-吡啶甲酸 | CAS号68470-59-7 2-溴甲基-6-甲基吡啶 | CAS号13287-64-4 (6-甲基吡啶-2-基)甲基乙酸酯 | CAS号3099-30-7 2-(氯甲基)-6-甲基吡啶盐酸盐 | CAS号171566-21-5 1,3-bis[bis[(6-... | CAS号125104-68-9 2-methyl-6-(pyr... | CAS号6630-11-1 1,2-双(6-甲基吡啶-2-...

2,6-二甲基吡啶置于tungsten(Iv) Oxide,双氧水,溶剂黄146,Potassium Hydroxide体系中,用 二氯甲烷 用作溶剂,化学反应 8.0H,反应生成6-甲基-2-吡啶基甲醇
参考文献:一种6-甲基-2-吡啶基甲醇的制备方法
标题:一种6-甲基-2-吡啶基甲醇的制备方法
摘要:本发明公开了一种6‑甲基‑2‑吡啶基甲醇的制备方法,属于化工有机合成领域.本发明解决了现有技术中存在的选择性差,副产物多,收率低以及污染环境等问题,以2,6‑二甲基吡啶和冰醋酸为原料,在催化剂氧化钨和双氧水的条件下将2,6‑二甲基吡啶高选择性氧化,在吡啶环的α位上引入一个乙酰基团,然后经α‑碳电子迁移重排生成6‑甲基‑2‑吡啶甲酸乙酯,然后水解生成6‑甲基‑2‑吡啶基甲醇,再通过萃取和蒸馏得到高纯度的6‑甲基‑2‑吡啶基甲醇,完全能满足医药生产企业合成需要.本发明的制备方法具有选择性高,副产物少,产品收率高,和生产成本低等优点,反应条件温和,适于工业化生产.

专利信息

专利号:US-8598166-B2
优先权日:2008-03-21
标 题:Polysubstituted derivatives of 6-heteroarylimidazo[1,2-a]pyridines, and preparation and therapeutic use thereof
发明人：DE PERETTI DANIELLE; EVANNO YANNICK; MACHNIK DAVID; RAKOTOARISOA NATHALIE
权利人:DE PERETTI DANIELLE; EVANNO YANNICK; MACHNIK DAVID; RAKOTOARISOA NATHALIE; SANOFI SA
摘要:Compounds of formula (I): n nwherein R 1 , R 2 , R 3 , R 4 , Het and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.

专利号:US-5721222-A
优先权日:1992-04-16
标 题 :Heterocyclic ketones
发明人：BERNSTEIN PETER ROBERT; SHAW ANDREW; THOMAS ROYSTON MARTIN; VEALE CHRIS ALLAN; WARNER PETER; WOLANIN DONALD JOHN
权利人:ZENECA LTD
摘要:The present invention relates to certain novel heterocyclic ketones which are 1-pyridylacetamide ketones of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic ketones, processes for preparing the heterocyclic ketones, pharmaceutical compositions containing such heterocyclic ketones and methods for their use.

专利号:US-6469172-B2
优先权日:2000-03-08
标题:Process for the preparation of chemical compounds
发明人：MALIGRES PETER E; LEE JAEMOON
权利人:MERCK & CO INC
摘要:An improved and efficient synthesis for the preparation of 2-amino-6-[(4-aminopiperidin-1-yl]methyl]pyridine, an intermediate compound in the preparation of muscarinic M3 receptor antagonists, includes as a final step the removal of trimethylacetyl and an amino protecting group from 2-trimethylacetyl-amino-6-[(4-protected aminopiperidin-1-yl)methyl]pyridine.