CAS: 108957-20-6; (R)-Benzyl 2-((Tert-Butoxycarbonyl)Amino)-3-Iodopropanoate

相似化合物

51814-54-1 141527-78-8 59524-02-6

上下游产品

benzyl 2(S)-(tert-butoxycarbonylamino)-3-p-toluenesulfonylpropionate N-tert-butoxycarbonyl-L-serine benzyl ester tert-butyl dicarbonatedi-tert-butyl dicarbonate L-serine benzyl ester benzenesulfonate salt-3-(2'-thienyl)propionatebenzyl 2(S)-(tert-butoxycarbonyl)amino-3-(2'-thienyl)propionate -3-(2'-pyridyl)propionatebenzyl 2(S)-(tert-butoxycarbonyl)amino-3-(2'-pyridyl)propionate -4(R/S)-phenylhex-5-enoateBenzyl 2(S)-(tert-butoxycarbonyl)amino-4(R/S)-phenylhex-5-enoate -3-(4'-nitrophenyl)propionatebenzyl 2(S)-(tert-butoxycarbonyl)amino-3-(4'-nitrophenyl)propionate

📜N-叔丁氧羰基-L-丝氨酸置于吡啶,Sodium Iodide体系中,用 丙酮 用作溶剂,化学反应生成N-Boc-3-碘-L-丙氨酸苄酯
参考文献:具有甘氨酸甘氨酸骨架的新型肽核酸单体的合成
标题:具有甘氨酸甘氨酸骨架的新型肽核酸单体的合成
摘要:制备了具有甘氨酸甘氨酸骨架的新型胸腺嘧啶肽核酸(pna)单体.这涉及碘化丝氨酸(3)和3-苯甲酰基胸腺嘧啶之间偶联的关键步骤.
Doi:10.1002/jhet.5570430445

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.