专利号:US-11530204-B2 优先权日:2019-09-30 标 题 :Biocatalytic synthesis of cryptophycin anticancer agents 发明人:SHERMAN DAVID H; SCHMIDT JENNIFER J 权利人:UNIV MICHIGAN REGENTS 摘要:The disclosure provides cryptophycin intermediates, cryptophycin analogs, and cryptophycin chimeric molecules useful in treating cancer, as well as methods of producing these compounds and methods of treating cancer.
专利号:WO-2024256370-A1 优先权日:2023-06-13 标 题 :Synthesis of glufosinate using an amidase-based process 发明人:ZIMMERMANN GUNTHER; POTT MORITZ STEFAN 权利人:BASF SE 摘要:The present invention relates to a method of preparing glufosinate, comprising the steps of hydrolysing an N-carbamoyl glufosinate amide with an Amidase enzyme to form an N- carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N- carbamoyl amino acid compound.
专利号:US-2025120400-A1 优先权日:2021-12-10 标题:Synthesis of glufosinate using a hydantoinase-based process 发明人:DITRICH KLAUS; BREUER MICHAEL; POTT MORITZ STEFAN; ZIMMERMANN GUNTHER; SEEMAYER STEFAN 权利人:BASF SE 摘要:The present invention relates to a method of manufacturing glufosinate, comprising the steps of hydrolysing a hydantoin with a Hydantoinase enzyme to form a N-carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N-carbamoyl amino acid compound.
专利号:US-9399664-B2 优先权日:2010-03-29 标题:Process for purification of pneumocandin 发明人:RASTOGI KUSHAL; SANTAN ONKAR PRAKASH; PATIL NITIN SOPANRAO; MENDHE RAKESH BHAIYYARAM 权利人:RASTOGI KUSHAL; SANTAN ONKAR PRAKASH; PATIL NITIN SOPANRAO; MENDHE RAKESH BHAIYYARAM; BIOCON LTD 摘要:The process described herein discloses purification process of a secondary metabolite produced by fermentation route. The process involves selective removal of impurities at various stages of washings, charcoalization followed by crystallization. The product is closely related to class of echinocandins and is found to be potent antifungal compound & a key ingredient in the synthesis of antifungal drugs.
专利号:EP-0830136-B1 优先权日:1995-03-07 标 题:New cryptophycins from synthesis 发明人:MOORE RICHARD E; TIUS MARCUS A; BARROW RUSSELL A; LIANG JIAN; CORBETT THOMAS H; VALERIOTE FREDERICK A; HEMSCHEIDT THOMAS K; GOLAKOTI TRIMURTULU 权利人:UNIV HAWAII; UNIV WAYNE STATE 摘要:Novel cryptophycin compounds are disclosed, together with methods of producing cryptophycins by total synthesis and methods for the use of such cryptophycins in pharmaceuticals to inhibit the proliferation of mammalian cells and to treat neoplasia.
专利号:US-6013626-A 优先权日:1993-12-21 标题 :Cryptophycins from synthesis 发明人:MOORE RICHARD E; TIUS MARCUS A; BARROW RUSSELL A; LIANG JIAN; CORBETT THOMAS H; VALERIOTE FREDERICK A; GOLAKOTI TRIMURTULU; HEMSCHEIDT THOMAS K 权利人:UNIV HAWAII; UNIV WAYNE STATE 摘要:A cryptophycin compound is provided having the structure: ##STR1## Further provided are methods of producing cryptophycins by total synthesis and methods of using cryptophycins in pharmaceuticals. It is a further object of this invention to use cryptophycins to inhibit the proliferation of mammalian cells. Moreover, methods of using cryptophycins to treat neoplasia is also provided.
参考标题:Biocatalytic Synthesis Of Cryptophycin Anticancer Agents 摘要:The Disclosure Provides Cryptophycin Intermediates, Cryptophycin Analogs, And Cryptophycin Chimeric Molecules Useful In Treating Cancer, As Well As Methods Of Producing These Compounds And Methods Of Treating Cancer.