2-甲基萘置于正庚烷,三乙基铝体系中,250.0 °C,12.75 Mpa 条件下,反应生成 萘 参考文献:Dealkylation Of Alkyl Naphthalenes In The Presence Of Organo-Aluminum Catalyst 标题:Dealkylation Of Alkyl Naphthalenes In The Presence Of Organo-Aluminum Catalyst
专利号:WO-2021014395-A1 优先权日:2019-07-24 标题:Process for the synthesis of deuterated capsaicin, capsaicinoids and synthetic capsaicin analogs 发明人:ORUGANTI SRINIVAS; AMRUTAPU SRAVANTH KUMAR; SAMPATH MAGESH; SEN SAIKAT 权利人:DR REDDY’S INST OF LIFE SCIENCES 摘要:The present application provides novel processes for the synthesis of deuterated intermediates of capsaicinoids, particularly II, III, IV and V of capsaicinoids, relating to pharmaceutical applications. The invention also provides novel intermediates of compounds of formula IX, XIV, XV, XVI, XVII, XVIII, XX and XXI utilized in the process of making deuterated capsaicin II, III, IV and V.
专利号:US-9701596-B2 优先权日:2013-06-25 标题:Synthesis of polycyclic aromatic hydrocarbons 发明人:JOHNSON RICHARD PETER; THAMATAM RAJESH 权利人:THE UNIV OF NEW HAMPSHIRE 摘要:The present invention relates to the synthesis of polycyclic aromatic compounds. Compounds such as terrylene or quaterrylene may now be prepared in relatively high yield by reaction of naphthalene or perylene via Scholl-type coupling in the presence of a superacid and an oxidant in an inert solvent.
专利号:US-7479569-B2 优先权日:2004-02-13 标题:Process for the synthesis of (7-methoxy-3,4-dihydro-1-naphthalenyl) acetonitrile and its application in the synthesis of agomelatine 发明人:SOUVIE JEAN-CLAUDE; GONZALEZ BLANCO ISAAC 权利人:SERVIER LAB 摘要:A process for the industrial synthesis of the compound of formula (I) n nApplication in the synthesis of agomelatine.
专利号:WO-0142264-A1 优先权日:1999-12-10 标 题 :Method for the synthesis of sialylated oligosaccharide donors 发明人:MEHTA SEEMA; GILBERT MICHEL; WAKARCHUK WARREN W; WHITFIELD DENNIS M 权利人:CA NAT RESEARCH COUNCIL; MEHTA SEEMA; GILBERT MICHEL; WAKARCHUK WARREN W; WHITFIELD DENNIS M 摘要:A method for the synthesis of aryl thioglycosides comprising a sialylated residue of β-D-galactose is disclosed. The method consists of preparing by a chemical synthesis a non-sialylated aryl thioglycoside, and enzymatically sialylating the latter with a sialic acid in the presence of a suitable sialyltransferase. The sialylated aryl thioglycoside is then chemically derivatized by standard procedures, to provide a derivative suitable for use as a donor in chemical syntheses of sialylated oligosaccharides. The derivatized sialylated aryl thioglycosides are prepared in high yields, due to reduced number of chemical and purification steps involved in the process. Derivatized aryl thioglycosides useful as building blocks for the synthesis of biologically active sialylated oligosaccharides are also disclosed.
专利号:US-2021323987-A1 优先权日:2018-08-20 标题:Methods for the Synthesis of Heteroatom Containing Polycyclic Aromatic Hydrocarbons 发明人:GARG NEIL K; DARZI EVAN R; BARBER JOYANN S; SUSICK ROBERT; CHARI JASON; SPENCE KATIE 权利人:UNIV CALIFORNIA 摘要:Methods for the synthesis of polycyclic aromatic hydrocarbons and synthesis platforms for performing such syntheses are provided. Methods and platforms are provided that allow for the synthesis of aza-polycyclic aromatic hydrocarbons by an expedient ring assembly. Methods and platforms allow for a modular approach to synthesis that provide multiple new C—C bonds in sequential pericyclic reactions, thus giving access to compounds with multiple axes of substitution.
专利号:WO-9837078-A1 优先权日:1997-02-20 标题 :Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes 发明人:DOERWALD FLORENCIO ZARAGOZA 权利人:NOVO NORDISK AS 摘要:A solid phase method for the synthesis of a plurality of differently substituted thiophenes with a wide variety of side-chain substituents as compounds of potential therapeutic interest. The thiophenes are prepared by reaction of a substrate-bound primary or secondary amine with a thiophosgene equivalent and reaction of the resulting intermediate with an acceptor-substituted acetonitrile in the presence of a base. Alkylation with an appropriate alkyl halide, followed by Thorpe-Ziegler-cyclization yields differently substituted, support-bound 3-aminothiophenes. These may be screened on the substrate or cleaved from the substrate and then screened in solution. Alternatively, the resin-bound 3-amino thiophenes or the synthetic intermediates can be subjected to further synthetic transformations (N-acylation, reduction) on the support, which permits the preparation of further therapeutically interesting compounds. The efficient synthesis of a wide variety of thiophenes using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse thiophene-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.
1: Tam TLD, Ng CK, Lu X, Lim ZL, Wu J. Anion-π interactions of highly π-acidic dipyridinium-naphthalene diimide salts. Chem Commun (Camb). 2018 Jun 18. doi: 10.1039/c8cc03941k. [Epub ahead of print] doi: 10.1016/j.ultsonch.2018.04.006. Epub 2018 Apr 26. doi: 10.1016/j.aca.2018.05.021. Epub 2018 May 11. doi: 10.1016/j.dib.2018.03.090. eCollection 2018 Jun. 6: Taublaender MJ, Glöcklhofer F, Marchetti-Deschmann M, Unterlass MM. Green and Rapid Hydrothermal Crystallization and Synthesis of Fully Conjugated Aromatic Compounds. Angew Chem Int Ed Engl. 2018 Jun 13. doi: 10.1002/anie.201801277. [Epub ahead of print] pii: E1421. doi: 10.3390/molecules23061421. pii: E980. doi: 10.3390/ma11060980. doi: 10.3389/fmicb.2018.01087. eCollection 2018. 11: Dutta K, Shityakov S, Khalifa I, Mal A, Moulik SP, Panda AK, Ghosh C. Effects of secondary carbon supplement on biofilm-mediated biodegradation of naphthalene by mutated naphthalene 1, 2-dioxygenase encoded by Pseudomonas putida strain KD9. J Hazard Mater. 2018 May 18;357:187-197. doi: 10.1016/j.jhazmat.2018.05.024. [Epub ahead of print] doi: 10.1016/j.chemosphere.2018.06.002. [Epub ahead of print] doi: 10.1016/j.phytochem.2018.05.019. [Epub ahead of print] doi: 10.1166/jbn.2018.2555. doi: 10.1016/j.saa.2018.05.096. [Epub ahead of print] doi: 10.1371/journal.pone.0198828. eCollection 2018.
合成参考文献
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