📜水杨酸置于吡啶,Chlorosulphuric Acid体系中,化学反应生成 2-(磺酰基氧基)苯甲酸 参考文献:Loeper; Cottet; Parrod,Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales,1941,Vol. 135,P. 917 标题:Loeper; Cottet; Parrod,Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales,1941,Vol. 135,P. 917
专利号:US-9433605-B2 优先权日:2006-03-23 标 题 :Method for promoting synthesis of tissue collagen 发明人:KAMIYA TOSHIKAZU; KAMIMURA AYAKO; KAWADA YOKO 权利人:KYOWA HAKKO BIO CO LTD 摘要:An object of the present invention is to provide an oral preparation for promoting synthesis of tissue collagen, an oral preparation for promoting healing of skin wounds or an oral preparation for preventing or improving skin wrinkles or sagging, which is safe and has an excellent effect. The present invention can provide an oral preparation for promoting synthesis of tissue collagen, an oral preparation for promoting healing of skin wounds or an oral preparation for preventing or improving skin wrinkles or sagging, which comprises hydroxyproline or a salt thereof as an active ingredient.
专利号:US-8546532-B2 优先权日:2008-04-17 标题:Synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders 发明人:BONNIN DUSTAN; ZANELLI ERIC; MATHERS THOMAS 权利人:BONNIN DUSTAN; ZANELLI ERIC; MATHERS THOMAS; DECLION PHARMACEUTICALS INC 摘要:The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the treatment and diagnosis of protein conformational disorders, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use. The invention also pertains to the process of generating antibodies using the directed epitope peptide mixtures as the antigens, and antibodies generated by such process, useful in the treatment and diagnostics of the said protein conformational disorder.
专利号:US-2025101006-A1 优先权日:2022-01-31 标题:Process for the synthesis of pyrazolyl derivatives useful as anti-cancer agents 发明人:BAENZIGER MARKUS; GALLOU FABRICE; GUO FENGFENG; HÄNGGI RUDOLF; HAN ENJIAN; JORDINE GUIDO; LI JIALIANG; LIU WEIPENG; MIAO BUKEYAN; RONG SHAOFENG; SANTANDREA ERNESTO; SCHIRNER PAUL BERND; SHEN XIAODONG; WANG CAN; ZHANG HAO 权利人:NOVARTIS AG 摘要:The invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially KRAS G12C inhibitors. The present invention provides a direct enantioselective chemical manufacturing method of making Compound A, or a pharmaceutically acceptable hydrate or solvent thereof: (I). The invention provides a process for preparing Intermediate B6* comprising reacting Intermediate B4* with Intermediate B5* in an atroposelective coupling reaction, using a chiral catalyst.
专利号:US-7435855-B2 优先权日:2004-06-18 标题:Process for the continuous synthesis of methylamines 发明人:BOSCH MARCO; EBERHARDT JAN KURT; ROETTGER RODERICH; KRUG THOMAS; MELDER JOHANN-PETER 权利人:BASF SE 摘要:Process for the continuous synthesis of methylamines by reaction of methanol and/or dimethyl ether with ammonia in the presence of a heterogeneous catalyst, wherein the catalyst used is a shaped body which comprises a microporous material and at least one organosilicon compound as binder and can be produced by a process comprising the stepsn (I) preparation of a mixture comprising the microporous material, the binder, a pasting agent and a solvent, (II) mixing and densification of the mixture, (III) shaping of the densified mixture to give a shaped body, (IV) drying of the shaped body and (V) calcination of the dried shaped body.
专利号:US-11708381-B2 优先权日:2016-11-25 标题:Inhibitors of androgen receptor signaling 发明人:WANG GUANGDI; LIU JIAWANG; ZHENG SHILONG; GUO SHANCHUN 权利人:XAVIER UNIV OF LOUISIANA 摘要:The present disclosure relates to androgen receptor signaling inhibitors and the synthesis of the same. Further, the present disclosure teaches the utilization of the androgen receptor signaling inhibitors in a treatment for proliferative diseases, including cancer, particularly prostate cancer, and especially castration-resistant prostate cancer.
专利号:US-7651968-B2 优先权日:2005-12-12 标 题:Shaped body comprising a microporous material and at least one silicon-containing binding agent method for production and use thereof as catalyst in particular in a method for continuous synthesis of methylamines 发明人:BOSCH MARCO; EBERHARDT JAN; ROETTGER RODERICH 权利人:BASF SE 摘要:A process for producing a shaped body comprising a microporous material and at least one silicon-comprising binder, which comprises the stepsn (I) preparation of a mixture comprising the microporous material, the binder and a lubricant, (II) mixing and densification of the mixture, (III) shaping of the densified mixture to give a shaped body and (IV) calcination of the shaped body,n nwherein a silicone resin having a softening point of ≧30° C. is used as binder,n nshaped bodies which can be produced by this process, their use as catalyst, in particular in organic synthesis and very particularly preferably in a process for preparing methylamines.
参考文献:10.1007/s00216-005-0201-8 摘要:Amin M, Lim LW, Takeuchi T. Serial separation of cations and anions by ion chromatography using the peak parking technique and sulfosalicylic acid as the eluent. Analytical and Bioanalytical Chemistry. 2005 Dec 01;384(3):839–43. doi: 10.1007/s00216-005-0201-8. 参考文献:10.3390/ijerph8062401 摘要:Miller G, Begonia G, Begonia MF. Selected morphological characteristics, lead uptake and phytochelatin synthesis by coffeeweed (Sesbania exaltata Raf.) grown in elevated levels of lead-contaminated soil. Int J Environ Res Public Health. 2011 Jun;8(6):2401–17. 参考文献:10.1093/jxb/err203 摘要:Chen L, Han Y, Jiang H, Korpelainen H, Li C. Nitrogen nutrient status induces sexual differences in responses to cadmium in Populus yunnanensis. Journal of Experimental Botany. 2011 Jul 21;62(14):5037–50. doi: 10.1093/jxb/err203.