CAS: 88-99-3; Phthalic Acid

上下游产品

ortho-methylbenzoic acid isoquinoline methanol (+/-)-phthalic acid mono-[1-(4-methoxy-phenyl)-ethyl ester]phthalic acid bis-(3-tetrahydro[2]furyl-propyl ester) phthalic anhydride H-pyran-3-carbonyl)-benzene1,2-bis-(2,6-dimethyl-4-oxo-4H-pyran-3-carbonyl)-benzene 2-(1H-quinolin-2-ylidene)-indan-1,3-dione

2-二氯甲基苯甲腈置于盐酸,乙酸酐体系中,化学反应生成 邻苯二甲酸
参考文献:Posner,Chemische Berichte,1897,Vol. 30,P. 1695
标题:Posner,Chemische Berichte,1897,Vol. 30,P. 1695

专利信息

专利号:US-8791287-B2
优先权日:2010-07-02
标 题:Process for the synthesis of tapentadol and intermediates thereof
发明人：MOTTA GIUSEPPE; VERGANI DOMENICO; BERTOLINI GIORGIO; LANDONI NICOLA
权利人:MOTTA GIUSEPPE; VERGANI DOMENICO; BERTOLINI GIORGIO; LANDONI NICOLA; EUTICALS SPA
摘要:The object of the present invention is a new process for the synthesis of tapentadol, both as free base and in hydrochloride form, which comprises the step of alkylation of the ketone (VII) to yield the compound (VIII), as reported in Diagram 1, with high stereoselectivity due to the presence of the benzyl group as substituent of the amino group. It was surprisingly found that this substitution shifts the keto-enol equilibrium towards the desired enantiomer and amplifies the capacity of the stereocenter present in the compound (VII) to orient the nucleophilic addition of the organometallic compound at the carbonyl towards the desired stereoisomer. This substitution thus allows obtaining a considerable increase of the yields in this step, and consequently allows significantly increasing the overall yield of the entire tapentadol synthesis process. n A further object of the present invention is constituted by the tapentadol free base in solid form, obtainable by means of the process of the invention. n Still another object of the invention is represented by the crystalline forms I and II of the tapentadol free base. n A further object of the present invention is the mixture of the crystalline forms I and II of the tapentadol free base.

专利号:US-2012203004-A1
优先权日:2009-08-13
标题 :process for the synthesis of alkyl/aralkyl (2s)-2-(tert-butoxycarbonyl)-amino-2-[-8-azabicyclo[3.2.1]oct-3-yl]-exo-acetate and analogs thereof: key intermediates for the preparation of dppiv inhibitors
发明人：ROY BHAIRAB NATH; KAMBOJ RAJENDER KUMAR; GOERGE SHAJI K; VENUGOPAL SPINVIN C; SHANMUGVADIVELU MUTHU KUMARAN; SINHA NEELIMA
权利人:ROY BHAIRAB NATH; KAMBOJ RAJENDER KUMAR; GOERGE SHAJI K; VENUGOPAL SPINVIN C; SHANMUGVADIVELU MUTHU KUMARAN; SINHA NEELIMA; LUPIN LTD
摘要:An improved process for the synthesis of intermediates like Alkyl/Aralkyl (2S)-2-(tert-butoxycarbonyl)-amino-2-[-8-azabicyclo[3.2.1]oct-3-yl]-exo-acetate and analogs thereof which are useful in the synthesis of Dipeptidyl peptidase-IV (DP-PIV) inhibitors.

专利号:WO-2017175101-A1
优先权日:2016-04-07
标 题:Synthesis of copper phthalocyanine using deep eutectic solvent
发明人：SHANKARLING G S; JOGLEKAR AMRUTA R
权利人:SHANKARLING G S
摘要:The present disclosure generally relates to synthesis of copper phthalocyanine. In particular, the present disclosure relates to a method of synthesis of copper phthalocyanine using deep eutectic solvent (DES), which can be carried out at low temperature, does not involve use of high boiling solvents, uses less urea and allows solvents used in the process to be recycled.

专利号:US-2024239737-A1
优先权日:2023-01-13
标题 :Synthesis of Triisoamyl Citrate (Triisopentanol) and its Applications as a Solvent, Plastizer and Component of Cosmetic and Aerosol Formulations
发明人：SATO SETSUO
权利人:BRASIL BIO FUELS S A
摘要:The present invention is based on the synthesis of triisoamyl citrate (triisopentanol citrate) and its applications as a plasticizer for polyvinyl chloride polymers, natural and synthetic rubbers, industrial solvents, replacing petrochemical-based products such as Phthalates (Dioctyl Phthalate, Diisononyl Phthalate, Dibutyl Phthalate), Acetylated tributylcitrate, epoxidized fatty esters, isoparaffins. It is a 100% renewable, high-performance, non-toxic, biodegradable product with an extremely competitive cost. With the increase in corn alcohol production in Brazil, this technology and product adds value to the fusel oil co-product generated in corn alcohol plants.

专利号:US-12263464-B2
优先权日:2018-03-14
标题 :Method for in-situ synthesis of metal organic frameworks (MOFs), covalent organic frameworks (COFs) and zeolite imidazolate frameworks (ZIFs), and applications thereof
发明人：PAHWA DEEPAK; PAHWA VARUN; CHOUDHARY ANIL KUMAR; SONIA; JHA VIVEK KUMAR; CHAUHAN ANJALI; YADAV ANNU
权利人:DESICCANT ROTORS INTERNATIONAL PRIVATE LTD
摘要:The present invention relates to a method for the in situ synthesis of of MOFs (metal organic frameworks), COFs (covalent organic frameworks), and ZIFs (Zeolitic imidazolate framework), onto and within different types of porous substrates, and their applications. The present invention provides a unique and easy to utilize method by which a number of MOFs, COFs and ZIFs can be synthesized directly onto and within a porous substrate with high performance efficiency ensuring higher grammage in formation of adsorbent product onto and within the substrate.

专利号:US-4902790-A
优先权日:1985-10-10
标 题 :Novel process for the synthesis of amikacin
发明人：MANGIA ALBERTO; GIOBBIO VICENZO; ORNATO GIORGIO
权利人:PIERREL SPA
摘要:A novel process for the synthesis of amikacin starting from kanamycin A protected at the positions 3 and 6' is described comprising the reaction of kanamycin A with a salt of a bivalent metal cation selected from zinc, nickel, iron, cobalt, manganese, copper and cadmium in the presence of water as the solvent or co-solvent followed by the in situ reaction of the resulting complex with a reactive derivative of L-amino-2-hydroxy-butyric acid, removal of the metal cation of the protecting groups and purification of the thus obtained raw product. The acylation under these conditions is extremely selective.