CAS: 871329-53-2; (5-(Methoxycarbonyl)Pyridin-3-yl)Boronic Acid

该化合物是一种多用途的boronic 衍生物,广泛用于铃木-米亚乌拉交叉组合反应,这是形成有机合成中碳-碳联系的一种关键方法. 甲氧基碳基集团的存在增强了其稳定性和回弹性,使其在制药和农用化学应用中特别宝贵. 该化合物是建造复杂的环流框架(如以为基的脚手架)的关键中间体. 它的高纯度和一贯性能确保催化转化的可靠结果. 此外, 丁酸混合物允许选择性的功能化,使目标分子得以精确修改. 它对于研究和工业规模合成来说都是合适的,它提供了一种反应和处理方便的平衡.

英文名称(5-(Methoxycarbonyl)Pyridin-3-yl)Boronic Acid
中文名称5-(甲氧羰基)吡啶-3-硼酸
IUPAC名称(5-(methoxycarbonyl)pyridin-3-yl)boronic acid
其它别名5-(甲氧基羰基)吡啶-3-硼酸; Methyl 5-Borononicotinate, Methyl 5-Boronopyridine-3-Carboxylate
CAS编号871329-53-2
MFCD编号:MFCD07363742
分子式:C7H8BNO4分子量:180.95
产品CID: 1876652
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: PGTWAVVFCNTGCS-UHFFFAOYSA-N
InChI=1S/C7H8BNO4/c1-13-7(10)5-2-6(8(11)12)4-9-3-5/h2-4,11-12H,1H3
计算化学: 氢键受体数5.0氢键供体数2可旋转键数2

相似化合物

1025718-91-5 913836-03-0 908369-20-0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xi
风险等级Irritant

合成工艺路线路线简述

海关参考信息

2912110000-甲醛
2915110000-甲酸
2933310010-吡啶
2909199090-其他醚及其衍生物
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详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-8487094-B2
优先权日:2008-07-25
标题 :Synthesis of inhibitors of 11Î²-hydroxysteroid dehydrogenase type 1
发明人：FANDRICK KEITH R; GAO JOE JU; LI WENJIE; LU ZHI-HUI; ZHANG YONGDA
权利人:FANDRICK KEITH R; GAO JOE JU; LI WENJIE; LU ZHI-HUI; ZHANG YONGDA; BOEHRINGER INGELHEIM INT
摘要:Disclosed are syntheses of 11Î²-HSD1 inhibitors and corresponding intermediates that are promising for the treatment of a variety of disease states including diabetes, metabolic syndrome, obesity, glucose intolerance, insulin resistance, hyperglycemia, hypertension, hypertension-related cardiovascular disorders, hyperlipidemia, deleterious gluco-corticoid effects on neuronal function (e.g. cognitive impairment, dementia, and/or depression), elevated intra-ocular pressure, various forms of bone disease (e.g., osteoporosis), tuberculosis, leprosy (Hansen's disease), psoriasis, and impaired wound healing (e.g., in patients that exhibit impaired glucose tolerance and/or type 2 diabetes).

专利号:WO-2009017671-A1
优先权日:2007-07-26
标题 :Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1

专利号:US-2010256363-A1
优先权日:2007-07-26
标题 :SYNTHESIS OF INHIBITORS OF 11ÃŸ-HYDROXYSTEROID DEHYDROGENASE TYPE 1

专利号:US-2011269957-A1
优先权日:2008-07-25
标题 :Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1

专利号:EP-2183229-B1
优先权日:2007-07-26
标题 :Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1

专利号:JP-2010534656-A
优先权日:2007-07-26
标题 :Synthesis of inhibitors of 11Î²-hydroxysteroid dehydrogenase type 1

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主要参考文献

参考标题: Synthesis Of Inhibitors Of 11Beta-Hydroxysteroid Dehydrogenase Type 1 Synthèse D'Inhibiteurs De La 11 -Hydroxystéroïde Déhydrogénase De Type 1
摘要:Disclosed Are Syntheses Of 11β-Hsd1 Inhibitors And Corresponding Intermediates That Are Promising For The Treatment Of A Variety Of Disease States Including Diabetes, Metabolic Syndrome, Obesity, Glucose Intolerance, Insulin Resistance, Hyperglycemia, Hypertension, Hypertension-Related Cardiovascular Disorders, Hyperlipidemia, Deleterious Gluco-Corticoid Effects On Neuronal Function (E.G. Cognitive Impairment, Dementia, And/or Depression), Elevated Intra-Ocular Pressure, Various Forms Of Bone Disease (E.G., Osteoporosis), Tuberculosis, Leprosy (Hansen'S Disease), Psoriasis, And Impaired Wound Healing (E.G., In Patients That Exhibit Impaired Glucose Tolerance And/or Type 2 Diabetes).