CAS: 66470-81-3; Tris(1,1,1,3,3,3-Hexafluoro-2-Propyl)Phosphite

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CAS号920-66-1 六氟异丙醇 | CAS号66559-58-8 dichloro-tris(1...

📜六氟异丙醇置于三乙胺,三氯化磷体系中,用73%的收率获得产物三(1,1,1,3,3,3-六氟-2-丙基)亚磷酸
参考文献:通过h-膦酸酯方法在寡聚脱氧核糖核苷酸合成中使用新的膦酰化和偶联剂
标题:通过h-膦酸酯方法在寡聚脱氧核糖核苷酸合成中使用新的膦酰化和偶联剂
摘要:使用三(1,1,1,3,3,3-六氟-2-丙基)亚磷酸酯作为膦酰化试剂来制备核苷3'-H-膦酸酯单元.还详细讨论了使用新型偶联剂1,3-二甲基-2-氯-咪唑啉鎓氯化物(dmci)通过h-膦酸酯方法形成核苷酸间h-膦酸酯键的方法.
DOI:10.1016/s0040-4039(01)93898-5

专利信息

专利号:US-5134228-A
优先权日:1988-09-29
标题:Nucleoside-3'-phosphites for synthesis of oligonucleotides
发明人：TAKAKU HIROSHI
权利人:CENTRAL GLASS CO LTD
摘要:The invention provides novel phosphites represented by the general formula (I) and nucleoside-3'-phosphite derivatives represented by the general formula (III). n n (RO).sub.3 P (I) n n wherein R is, for example, a fluoroalkyl group or a substituted phenyl group. ##STR1## wherein R is the same as in (I), R' is a protecting group such as dimethoxytrityl group, and B represents a base, e.g. thymine. n A phosphite (I) is prepared by reacting an alcohol ROH with PCl 3 in the presence of a tertiary amine, and a nucleoside-3'-phosphite (III) is prepared by reacting a phosphite (I) with a nucleoside in a solvent in the presence of a tertiary amine. Phosphites (I) are very stable. Using a nucleoside-3'-phosphite (III) an oligonucleotide can be synthesized on a solid support by a simplified process.

专利号:EP-1112281-B1
优先权日:1998-09-08
标 题:Pteridine nucleotide analogs
发明人：HAWKINS MARY E; PFLEIDERER WOLFGANG; BALIS FRANK
权利人:US GOV HEALTH & HUMAN SERV
摘要:The invention provides pteridine nucleotides of formula (I) which are highly fluorescent and which can be used in the chemical synthesis of fluorescent oligonucleotide. The invention further provides for fluorescent oligonucleotide comprising one or more pteridine nucleotides. In addition the invention provides for pteridine nucleotide triphosphates which may be used as the constituent monomers in DNA amplification procedures. The pteridine nucleotides are more stable and possess higher quantum yields than structurally similar pteridine nucleotides.

专利号:US-9273084-B2
优先权日:2012-04-06
标 题 :Moenomycin analogs, methods of synthesis, and uses thereof
发明人：KAHNE DANIEL EVAN; KAHNE SUZANNE WALKER; TSUKAMOTO HIROKAZU
权利人:HARVARD COLLEGE
摘要:The present invention provides compounds of Formula (I); or a pharmaceutically acceptable form thereof; wherein R 1 ,R 2 ,R 3 ,R 6 ,R 7 ,R 12 ,R a , and R b are as defined herein, and G is a group of Formula (a), (b), or (c): Formula (II), wherein X 1 ; X 2 , X 3 , X 4 , X 5 , X 6 , X 7 , Y, R C , R d , R z , a, d, e, x, n, and m are as defined herein. The present invention further provides pharmaceutical compositions comprising a compound of Formula (I), kits comprising such compositions, methods of use and treatment, and preparative methods.

专利号:US-6716971-B1
优先权日:1998-09-08
标题:Pteridine nucleotide analogs
发明人：HAWKINS MARY E; PFLEIDERER WOLFGANG; BALIS FRANK
权利人:US HEALTH
摘要:The invention provides pteridine nucleotides of formula (I) which are highly fluorescent and which can be used in the chemical synthesis of fluorescent oligonucleotide. The invention further provides for fluorescent oligonucleotide comprising one or more pteridine nucleotides. In addition the invention provides for pteridine nucleotide triphosphates which may be used as the constituent monomers in DNA amplification procedures. The pteridine nucleotides are more stable and possess higher quantum yields than structurally similar pteridine nucleotides.

专利号:DE-3932471-A1
优先权日:1988-09-29
标题 :NEW PHOSPHITE AND NUCLEOSIDE-3'-PHOSPHITE FOR THE SYNTHESIS OF OLIGONUCLEOTIDES

专利号:US-5612468-A
优先权日:1994-05-18
标题:Pteridine nucletide analogs as fluorescent DNA probes
发明人：HAWKINS MARY E; PFLEIDERER WOLFGANG; DAVIS MICHAEL D; BALIS FRANK
权利人:US HEALTH
摘要:The invention provides novel pteridine nucleotides which are highly fluorescent under physiological conditions and which may be used in the chemical synthesis of fluorescent oligonucleotides. The invention further provides for fluorescent oligonucleotides comprising one or more pteridine nucleotides. In addition the invention provides for pteridine nucleotide triphosphates which may be used as the constituent monomers in DNA amplification procedures.