CAS: 59782-90-0; 2,3-Dichloro-5-Methylpyridine

相似化合物

1256811-44-5 59782-88-6 65189-15-3

上下游产品

CAS号27313-32-2 2,2-dichloropropanal | CAS号107-13-1 丙烯腈 | CAS号90044-00-1 2,4-dichloro-4-... | CAS号34552-13-1 5-甲基-3-氨基-2-氯吡啶 | CAS号78-85-3 2-甲基丙烯醛 | CAS号3018-12-0 二氯乙腈

📜3-甲基吡啶置于氯,钼体系中,用 苯 作为反应溶剂,化学反应生成 2,3-二氯-5-甲基吡啶
参考文献:一种高效合成吡啶类氯代物的方法
标题:一种高效合成吡啶类氯代物的方法
摘要:本发明公开了一种高效合成吡啶类氯代物的方法,将甲基吡啶在溶剂中,通氯经过配体催化剂活化.活化结束后,分离去除溶剂,得到活化后甲基吡啶,在一定温度下进行通氯气反应,反应结束后通过蒸馏分离得到2,3‑二氯‑5‑三氯甲基吡啶.本发明工艺采用高效配体催化剂先对甲基吡啶进行活化,然后在进行通氯氯化,氯代过程有较高的选择性,同时反应条件较为温和,设备操作简单,反应过程多氯杂质产生极少,具有较高的操作性和经济性.

专利信息

专利号:US-8828907-B2
优先权日:2009-03-25
标题:Active ingredient combinations having insecticidal and acaricidal properties
发明人：HUNGENBERG HEIKE; JESCHKE PETER; VELTEN ROBERT; THIELERT WOLFGANG
权利人:HUNGENBERG HEIKE; JESCHKE PETER; VELTEN ROBERT; THIELERT WOLFGANG; BAYER CROPSCIENCE AG
摘要:The present invention relates to novel active compound combinations comprising, firstly, at least one known compound of the formula (I) n nin whichn nR 1 and A have the meanings given in the descriptionn nand, secondly, at least one further known active compound from the class of the chitin synthesis inhibitors, the molting hormone agonists or other classes, which combinations are highly suitable for controlling animal pests such as insects and unwanted acarids.

专利号:US-9771379-B2
优先权日:2015-09-24
标题:N-(2-(2-amino-6-substituted-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]OXAZIN-8a(8H)-yl)-thiazol-4-yl) amides
发明人：BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; ZHANG LEI; O'NEILL BRIAN THOMAS
权利人:PFIZER
摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n nwherein the variables R 1 , R 2 , R 3 , R 4 and X are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:WO-2014158302-A1
优先权日:2013-03-25
标 题:Novel sphingosine 1-phosphate receptor antagonists
发明人：SWENSON ROLF ERIC
权利人:SWENSON ROLF ERIC
摘要:The present invention relates to sphingosine-1 -phosphate (S1 P) receptors and compounds of the general formula (1), that are useful in the treatment and prevention of conditions associated with such receptors. More specifically, the present invention relates to the synthesis and use of sphingosine 1 -phosphate receptor 2 (S1 P2) antagonists that are useful in the treatment of cancer, atherosclerosis, diabetic retinopathy, and other inflammatory diseases. Among these inflammatory diseases that could be treated with these S1 P2 antagonist are those characterized by fibrosis including chronic lung disease, chronic kidney and liver disease, chronic heart disease, and skin diseases such as sclerosis/scleroderma. The S1 P2 antagonists can also be used in the treatment of glioblastoma multiforme (brain cancer), pediatric neuroblastoma, and other cancers.

专利号:US-9663511-B2
优先权日:2012-03-26
标题:Sphingosine 1-phosphate receptor antagonists
发明人：SWENSON ROLF E
权利人:ARROYO BIOSCIENCES LLC
摘要:The present invention relates to sphingosine-1-phosphate (S1P) receptors and compounds of the general formula: n nthat are useful in the treatment and prevention of conditions associated with such receptors. More specifically, the present invention relates to the synthesis and use of sphingosine 1-phosphate receptor 2 (S1P 2 ) antagonists that are useful in the treatment of cancer, atherosclerosis, diabetic retinopathy, and other inflammatory diseases. Among these inflammatory diseases that could be treated with these S1P 2 antagonist are those characterized by fibrosis including chronic lung disease, chronic kidney and liver disease, chronic heart disease, and skin diseases such as sclerosis/scleroderma. The S1P 2 antagonists can also be used in the treatment of glioblastoma multiforme (brain cancer), pediatric neuroblastoma, and other cancers.

专利号:CN-111333568-B
优先权日:2020-04-16
标题 :A kind of selective synthesis method of 2-chloro-5-methylpyridine and 2,3-dichloro-5-methylpyridine

专利号:CN-111333568-A
优先权日:2020-04-16
标题:A kind of selective synthesis method of 2-chloro-5-methylpyridine and 2,3-dichloro-5-methylpyridine