CAS: 58864-81-6; (R)-2,5,7,8-Tetramethyl-2-((3E,7E)-4,8,12-Trimethyltrideca-3,7,11-Trien-1-yl)Chroman-6-Ol

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(R)-6-(benzyloxy)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl)chromane (S)-[3,4-dihydro-6-benzyloxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl]methyl trifluoromethane-sulfonate tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-2,5,7,8-tetramethyl-chroman6-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-2,5,7,8-tetramethyl-chroman tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5,7,8-trimethyl-chroman-2-yl]-methanol[6-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5,7,8-trimethyl-chroman-2-yl]-methanol(R)-6-(3,5-dimethoxybenzyl)oxy-2,5,7,8-tetramethyl-2-((3'E,7'E)-4',8',12'-trimethyltrideca-3',7',11'-trienyl)chroman (R)-2,5,7,8-tetramethyl-2-((3'E,7'E)-4',8',12'-trimethyltrideca-3',7',11'-trienyl)chroman-6-yl tosylcarbamate (R)-2,5,7,8-tetramethyl-2-((3'E,7'E)-4',8',12'-trimethyltrideca-3',7',11'-trienyl)chroman-6-yl phenylcarbamate (R)-2,5,7,8-tetramethyl-2-((3'E,7'E)-4',8',12'-trimethyltrideca-3',7',11'-trienyl)chroman-6-yl 4-chlorophenylsulfonylcarbamate

📜2,3,5-三甲基苯酚置于吡啶,Copper Acetylacetonate,N-溴代丁二酰亚胺(Nbs),正丁基锂,[1,3-双(二苯基膦基)丙烷]二氯化钯(II),N1,N2-Bis(4-Hydroxy-2,6-Dimethylphenyl)Oxalamide,四丁基氟化铵,水,Sodium Hydride,三乙基硼氢化锂,碳酸氢钠,二正丁胺,溶剂黄146,Potassium Hydroxide体系中,用 四氢呋喃,六甲基磷酰三胺,正己烷,二氯甲烷,甲基叔丁基醚,水,二甲基亚砜,N,N-二甲基甲酰胺,Mineral Oil 作为反应溶剂,-70.0~160.0 °C,1.2 Mpa 条件下,反应 63.67H,反应生成 α-生育三烯醇
参考文献: Synthesis Of Tocotrienols From O-Cresol Derivatives[fr] Synthèse De Tocotriénols à Partir De Dérivés De O-Crésol
标题: Synthesis Of Tocotrienols From O-Cresol Derivatives[fr] Synthèse De Tocotriénols à Partir De Dérivés De O-Crésol
摘要:本发明提供了一种环境友好,简便的工艺,用于从商业上可获得的邻甲酚衍生物制备生育三烯酚.