专利号:US-9550757-B2 优先权日:2010-03-05 标题:Nuclear transport modulators and uses thereof 发明人:SHACHAM SHARON; KAUFFMAN MICHAEL; SANDANAYAKA VINCENT P; SHECHTER SHARON 权利人:KARYOPHARM THERAPEUTICS INC 摘要:The invention generally relates to the field of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to new substituted-heterocyclic azole compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity such as in treating cancer and other neoplastic disorders, inflammatory diseases, disorders of abnormal tissue growth and fibrosis including cardiomyopathy, pulmonary fibrosis, hepatic fibrosis, glomerulonephritis, and other renal disorders, and for the treatment of viral infections (both acute and chronic).
专利号:CN-102190797-A 优先权日:2010-03-08 标 题 :Rapid synthesis method and application of triazine-based covalently bonded organic framework material with nanoholes
专利号:CN-102190797-B 优先权日:2010-03-08 标 题 :Rapid synthesis method and application of triazine-based covalently bonded organic framework material with nanoholes