专利号:US-2003162992-A1 优先权日:2001-12-14 标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides 发明人:WATANABE KYOICHI A; DU JINFA 摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.
专利号:US-6432294-B1 优先权日:2000-12-14 标题 :Electrochemical activation of organic disulfides for electrophilic substitution 发明人:GLASS RICHARD S; JOUIKOV VIATCHESLAV V; BOJKOVA NINA V 权利人:UNIV ARIZONA 摘要:Electrochemical oxidation of organic disulfides is conducted in an electrolytic solution containing an arene (e.g., anthracene, acenaphthylene, phenanthrene), and depending on the arene used and/or the product desired, an organic base (e.g., pyridine) to effect the synthesis of organothiated products in good yields.
专利号:US-6713607-B2 优先权日:1994-03-08 标 题:Effector proteins of Rapamycin 发明人:CAGGIANO THOMAS J; CHEN YANQIU; FAILLI AMEDEO A; MOLNAR-KIMBER KATHERINE L; NAKANISHI KOJI 权利人:WYETH CORP; UNIV COLUMBIA 摘要:This invention comprises novel Rapamycin-FKBP12 binding proteins of mammalian origin for identification, design and synthesis of immunomodulatory, anti-restenosis or anti-tumor agents, as well as fragments of the proteins and the DNA, cDNA, antisense RNA and DNA segments corresponding to the proteins. This invention also comprises methods for isolating the proteins and therapeutic uses related to the proteins.
专利号:US-3948320-A 优先权日:1975-03-14 标 题:Method of in situ gasification, cooling and liquefaction of a subsurface coal formation 发明人:TERRY RUEL C 权利人:IN SITU TECHNOLOGY INC 摘要:A method of liquefying a coal formation in situ wherein the coal formation has been preheated as by a coal gasification project, includes the steps of establishing injection and removal passages connecting the coal formation to the surface, injecting water having a temperature below the formation temperature into the formation to gradually lower the temperature of the formation while forming synthesis gas, injecting a solvent material, having the capability of dissolving the coal, into the formation after it has been reduced to the desired temperature, injecting synthesis gas into the formation to hydrogenate the coal, allowing the formation to subside as the coal is dissolved therein so that more surface area of coal is exposed to the solvent, and removing the admixture of coal and solvent material from the formation as a synthetic crude oil.
专利号:US-6207838-B1 优先权日:1999-04-30 标 题 :Electrochemically generated organothiating reagents and their use 发明人:GLASS RICHARD S; JOUIKOV VIATCHESLAV V 权利人:UNIV ARIZONA 摘要:Electrolysis of organic disulfides in liquid sulfur dioxide is used to obtain organothiating agents, which can then be reacted with appropriate substrates to effect the synthesis of organothioaromatic compounds efficiently and in high yields. With appropriate phenolic compounds, regioselective substitution occurs in which para substitution greatly exceeds ortho substitution.
专利号:CA-2470202-A1 优先权日:2001-12-14 标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides
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