合成目标产物 2,2,3-Trimethylbutane 主要起始原料 Methanol And 2,3-Dimethylbutane
(文献来源)合成步骤主要原料 Methanol 和 2,3-Dimethylbutane
2,2,3-三甲基戊烷置于kieselguhr,氢气,镍体系中,化学反应生成 2,2,3-三甲基丁烷 参考文献:Haensel; Ipatieff,Journal Of The American Chemical Society,1946,Vol. 68,P. 346 标题:Haensel; Ipatieff,Journal Of The American Chemical Society,1946,Vol. 68,P. 346
专利信息
专利号:US-2003162992-A1 优先权日:2001-12-14 标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides 发明人:WATANABE KYOICHI A; DU JINFA 摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.
专利号:WO-2013065009-A1 优先权日:2011-11-01 标题:A sortase-click reaction suite for synthesis of multivalent dendrimeric protein assembly 发明人:GUPTA KANCHAN; SINGH SHIKHA; KHAN NAEEM; SEHGAL DEVINDER; ROY RAJENDRA PRASAD 权利人:NAT INST IMMUNOLOGY 摘要:The present invention relates to synthesis of bio-conjugates and well-defined multivalent protein dendrimer assembly by a general and straightforward chemo- enzymatic method. The method involves a simple two-step process in which proteins appended with an orthogonal label by facile sortase-mediated ligation are conjugated to a multivalent dendritic scaffold using the versatile copper-catalyzed azide-alkyne cycloaddition reaction. The 'Sortase-Click' strategy produces satisfactory yield of dendrimers under mild conditions from readily available His6 -tagged proteins and serves as a powerful general strategy for covalent assembly of bio-conjugates and protein dendrimers.
专利号:US-7504524-B2 优先权日:2004-07-26 标题:Method for synthesis of 2,5-dioxane-1,4-diones 发明人:BOURISSOU DIDIER; MARTIN-VACA BLANCA; BEN FREDERIC; GRAULLIER MAGALIE; CHERIF-CHEIKH ROLAND; MONTES MARTIN 权利人:SOD CONSEILS RECH APPLIC 摘要:The invention relates to a novel method for the synthesis of 2,5-dioxane-1,4-diones having formula (I), comprising the oxidation of the ketone function of a cyclic compound having formula (II), wherein R 1 , R 2 , R 3 and R 4 independently represent the hydrogen atom, halo, (C 2 -C 6 ) alkenyl, (C 3 -C 7 )cycloalkyl, cyclohexenyl and a radical having formula —(CH 2 ) m —V—W.
专利号:WO-2015183067-A1 优先权日:2014-05-30 标题 :Synthesis of analogues of y-amino acids and resulting products 发明人:FERNÃ?NDEZ ZERTUCHE MARIO; TOVAR GUDIÑO ERIKA; TRUJILLO FERRARA JOSÉ GUADALUPE; GUEVARA SALAZAR JUAN ALBERTO 权利人:UNIV AUTÓNOMA DEL ESTADO DE MORELOS 摘要:The invention relates to a compound of formula (see formula), suitable for use as drugs in the treatment of chronic neurodegenerative disorders of the Huntington's disease, Parkinson's disease and epilepsy type, inter alia . The invention relates to novel methods for the synthesis of said analogues and the pharmaceutically acceptable solvates and salts thereof.
专利号:US-8889926-B2 优先权日:2011-06-30 标 题:Method for the synthesis of low cost initiators for telechelic polyisobutylenes 发明人:KENNEDY JOSEPH P; ERDODI GABOR 权利人:KENNEDY JOSEPH P; ERDODI GABOR; UNIV AKRON 摘要:A method for the synthesis of 1,3-di(chloropropyl)-5-tert-butyl benzene includes the steps of conducting Friedl-Crafts alkylation of 1,3-diisopropyl benzene by tert-butyl chloride in the presence of an alkylation catalyst to obtain 1-tert-butyl-3,5-diisopropylbenzene; peroxidizing the 1-tert-butyl-3,5-diisopropyl benzene by gaseous oxygen in the presence of a peroxidation catalyst in a basic solution to obtain 1,3-di(peroxypropyl)-5-tert-butylbenzene; reducing the 1,3-di(peroxypropyl)-5-tert-butylbenzene with a reducing agent to 1,3-di(hydroxylpropyl)-5-tert-butylbenzene; and chlorinating the 1,3-di(hydroxypropyl)-5-tert-butylbenzene to obtain 1,3-di(chloropropyl)-5-tert-butyl benzene.
专利号:WO-2005103035-A1 优先权日:2004-04-23 标题:Modified fischer indole synthesis of eletriptan 发明人:ASHCROFT CHRISTOPHER PAUL 权利人:PFIZER LTD; ASHCROFT CHRISTOPHER PAUL; PFIZER 摘要:The present invention relates to a new process for the preparation of eletriptan (I), or its enantiomer comprising a modified Fischer indole synthesis, namely the reaction of a compound of formula (II), wherein R1 is a suitable hydrazine protecting group, with a compound of formula (III) wherein R2 is an aldehyde group (-CHO) or the functional equivalent thereof.
参考文献:10.2165/11590370-000000000-00000 摘要:Källén B, Nilsson E, Otterblad Olausson P. Delivery outcome after maternal use of drugs for migraine: a register study in Sweden. Drug Saf. 2011 Aug 01;34(8):691–703. doi: 10.2165/11590370-000000000-00000. 参考文献:10.1007/s10194-011-0364-y 摘要:Gaul C, Visscher CM, Bhola R, Sorbi MJ, Galli F, Rasmussen AV, Jensen R. Team players against headache: multidisciplinary treatment of primary headaches and medication overuse headache. The Journal of Headache and Pain. 2011 Jul 21;12(5):511–9. doi: 10.1007/s10194-011-0364-y.