CAS: 3964-56-5; 4-Bromo-2-Chlorophenol

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CAS号95-57-8 邻氯苯酚 | CAS号2446-83-5 偶氮二甲酸二异丙酯 | CAS号106-41-2 对溴苯酚 | CAS号108-95-2 苯酚 | CAS号4526-56-1 2,4-二溴-6-氯苯酚 | CAS号50638-47-6 2-氯-4-溴苯甲醚 | CAS号704892-51-3 6-bromo-2-chlor... | CAS号2973-80-0 2-溴-5-羟基苯甲醛 | CAS号64-19-7 冰醋酸 | CAS号50638-47-6 2-氯-4-溴苯甲醚 | CAS号56872-27-6 3-氯-4-苄氧基溴苯 | CAS号201849-21-0 4-溴-2-氯-1-异丙氧基苯 | CAS号19652-33-6 5-溴-3-氯-2-羟基苯甲醛 | CAS号185527-66-6 methyl 3-(3-chl... | CAS号619-08-9 2-氯-4-硝基酚 | CAS号58349-01-2 4-溴-2-氯-6-硝基苯酚 | CAS号2315-81-3 3-氯-4-羟基苯甲腈 | CAS号629658-06-6 3-氯-4-羟基苯硼酸频那醇酯 | CAS号102932-05-8 4-溴-2-氯乙酸苯酯

邻氯苯酚置于溶剂黄146,Potassium Bromide体系中,用 水,溶剂黄146 作为反应溶剂,以82%的收率获得产物4-溴-2-氯苯酚
参考文献:Kbr 和 Znal-Bro3−-层状双氢氧化物对苯酚进行区域选择性单溴化
标题:Kbr 和 Znal-Bro3−-层状双氢氧化物对苯酚进行区域选择性单溴化
摘要:以 Kbr 和 Znal-Bro3--层状双氢氧化物(缩写为 Znal-Bro3--Ldhs)作为溴化试剂,成功开发了苯酚的区域选择性单溴化反应.对位点比较有利,如果对位点被占用,则邻位点优先.该反应具有优异的区域选择性,廉价的溴化试剂,反应条件温和,原子经济性高,底物范围广等特点,为溴代苯酚的合成提供了一种有效的方法.
DOI:10.3390/molecules25040914

专利信息

专利号:US-11512062-B2
优先权日:2018-10-15
标 题:Process for the synthesis of piperazinyl-ethoxy-bromophenyl derivates and their application in the production of compounds containing them
发明人：BEAUREGARD LOUIS-PHILIPPE; BERTRAND MARTIAL; GIGUERE PASCALL; HARDOUIN CHRISTOPHE; SCHIAVI BRUNO
权利人:SERVIER LAB
摘要:Process for the industrial synthesis of the compound of formula (I):

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:WO-2024201396-A1
优先权日:2023-03-31
标 题 :Preparation of profenofos and its intermediates using flow chemistry techniques
发明人：DALAWAT DEVENDRA SINGH; KADLAG MANOJ; KULKARNI JAYANT JEEVAN; AMETA KAVITA; KASHYAP GUNJAN; HIDUPUR H RAM MOHAN
权利人:PI INDUSTRIES LTD
摘要:The present invention relates to a method for the preparation of profenofos and its intermediates using flow chemistry techniques. The present invention more particularly relates to the synthesis of profenofos and its intermediates in a microchannel reactor system.

专利号:US-8513465-B2
优先权日:2008-02-04
标题:Potassium organotrifluoroborate derivative and a production method therefor
发明人：KANG HEONJOONG; HAM JUNGYEOB; AHN HONG RYUL; PARK YOUNG HEE
权利人:KANG HEONJOONG; HAM JUNGYEOB; AHN HONG RYUL; PARK YOUNG HEE; SNU R&DB FOUNDATION
摘要:Provided are a production method for a potassium organotrifluoroborate compound having a hydroxyl group, and a novel potassium organotrifluoroborate compound having a hydroxyl group. The production method is advantageous in that a potassium organotrifluoroborate compound can be produced in a single reaction without recourse to a process of isolating and purifying an intermediate. The novel potassium organotrifluoroborate compound having a hydroxyl group is useful as a reactant which is widely used in the total synthesis of physiologically active natural products and diverse organic synthesis reactions including halogen substitution reactions, 1,2- and 1,4-addition reactions using a rhodium (Rh) catalyst, and Suzuki coupling reactions using a palladium (Pd) catalyst.

专利号:US-9994558-B2
优先权日:2013-09-20
标题 :Multicyclic compounds and methods of using same
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).

专利号:WO-2020078875-A1
优先权日:2018-10-15
标题:New process for the synthesis of piperazinyl-ethoxy-bromophenyl derivates and their application in the production of compounds containing them