CAS: 3788-94-1; Ethyl 2-(Ethoxymethylene)-3-Oxobutanoate

相似化合物

87-13-8 3044-06-2 66975-53-9

上下游产品

CAS号141-97-9 乙酰乙酸乙酯 | CAS号122-51-0 原甲酸三乙酯 | CAS号149-73-5 原甲酸三甲酯 | CAS号75-03-6 碘乙烷 | CAS号14036-06-7 乙酸二乙氧基甲酯 | CAS号108-24-7 乙酸酐 | CAS号33142-24-4 2-甲酰基-3-氧代丁酸乙酯 | CAS号108123-81-5 Ethyl 2-(benzyl... | CAS号105892-51-1 3-acetyl-7-chlo... | CAS号306960-67-8 2-三氟甲基-4-甲基嘧啶-5-羧酸乙酯 | CAS号42831-50-5 5-甲基-4-甲酸异噁唑 | CAS号288252-73-3 ethyl 1-(4-fluo... | CAS号1149-24-2 2,6-二甲基吡啶-3,5-二甲酸二乙酯 | CAS号89193-16-8 5-甲基-1-苯基-1H-吡唑... | CAS号113502-46-8 ethyl 3-methyl-... | CAS号998-91-4 3-乙氧基-2-丁炔羧酸乙酯 | CAS号81633-29-6 2-氨基-4-甲基嘧啶-5-羧酸乙酯

2-甲酰基-3-氧代丁酸乙酯,原甲酸三乙酯 反应生成2-乙氧亚甲基乙酰乙酸乙酯
参考文献:Claisen,Justus Liebigs Annalen Der Chemie,1897,Vol. 297,P. 57
标题:Claisen,Justus Liebigs Annalen Der Chemie,1897,Vol. 297,P. 57

专利信息

专利号:US-9676726-B2
优先权日:2013-12-23
标题:Process for the regioselective synthesis of pyrazoles
发明人：MEAZZA GIOVANNI; SILLANI LAURA; MEREGHETTI PIERANGELO; FORGIA DANIELE
权利人:ISAGRO SPA
摘要:A process is described for the synthesis of pyrazoles having general formula (I) n nwhich comprises the steps of mixing a compound having general formula (II)n n nand a 1,2-disubstituted hydrazine having general formula (III)n n nto form a reaction intermediate having general formula (IV)n n nand the reaction mixture obtained in step i), in an acid environment, cyclizes to form a pyrazole having general formula (I), according to reaction scheme 1

专利号:WO-2015155713-A1
优先权日:2014-04-09
标题 :Process for the regioselective synthesis of 1,3, 4 -substituted pyrazoles
发明人：MEAZZA GIOVANNI; MEREGHETTI PIERANGELO; SILLANI LAURA; FORGIA DANIELE; BELLANDI PAOLO
权利人:ISAGRO SPA
摘要:A process is described for the synthesis of pyrazoles having general formula (I) comprising the following steps: a) a mixture comprising an alkyl-hydrazine having formula (II) RNH-NH 2 and a compound having general formula (III) Rx 1 -X 1 -Rx-X 2 -Rx 2 , b) the mixture obtained in step a) is reacted with a compound having formula (IV), obtaining a 1,3,4-substituted pyrazole having general formula (I), according to the reaction scheme 1.

专利号:EP-3087058-A1
优先权日:2013-12-23
标 题:Process for the regioselective synthesis of pyrazoles

专利号:EP-3087058-B1
优先权日:2013-12-23
标 题:Process for the regioselective synthesis of pyrazoles

专利号:US-2016318874-A1
优先权日:2013-12-23
标 题:Process for the regioselective synthesis of pyrazoles

专利号:US-6552018-B1
优先权日:1997-01-27
标 题:Pyrazole derivatives
发明人：EJIMA AKIO; OHSUKI SATORU; OHKI HITOSHI; NAITO HIROYUKI
权利人:DAIICHI SEIYAKU CO
摘要:The present invention relates to cis- and trans-forms of pyrazole derivatives, salts thereof, or agents containing the same, and represented by the general formula (I): n wherein G represents a nitrogen containing saturated heterocyclic structure represented by the following formula: n These compounds exhibit anti-tumor activity on 5-FU-resistant tumors and effects on P glycoprotein expressing, multiple-drug resistant tumors. An example of a pyrazole derivative which demonstrates 50% inhibition of tumor cell growth is 3-[4-(3-chloro-5-fluorophenyl)- 1 piperazinyl]-1-[1-(3-chloro-2-pyridyl)-5-methyl-4-pyrazolyl)-1-trans-propene hydrochloride. Synthesis of the compounds represented by formula (I) can be prepared by any one of various routes such as a Mannich reaction, a Wittig reaction, reductive amination or substitution by allylation.