CAS: 3549-23-3; Methyl 2-(4-(Tert-Butyl)Phenyl)Acetate

上下游产品

methanol 4-tert-butylbenzyl cyanide 4-tert-butylbenzyl chloride carbon monoxidemethyl 2-bromo-2-(4-tert-butylphenyl)ethanoate 2-[2-(4-t-butylphenyl)acetyl]-2-ethyl-1,3-dithiane 2-(4-tert-butylphenyl)ethanol methyl 2-(4-t-butylphenyl)butanoate

📜对叔丁基氯苄置于水,对甲苯磺酸体系中,用 甲醇 用作溶剂,化学反应生成对叔丁基苯乙酸甲酯
参考文献:非咪唑组胺h3配体.第一部分.合成具有h1封闭活性的h3拮抗剂的2-(1-哌嗪基)-和2-(六氢-1H-1,4-二氮杂-1-基)苯并噻唑衍生物.
标题:非咪唑组胺h3配体.第一部分.合成具有h1封闭活性的h3拮抗剂的2-(1-哌嗪基)-和2-(六氢-1H-1,4-二氮杂-1-基)苯并噻唑衍生物.
摘要:制备了新的2-(1-哌嗪基)-和2-(六氢-1H-1,4-二氮杂-1-基)苯并噻唑并作为h1-和h3-受体拮抗剂进行了测试.许多化合物表现出较弱的h1拮抗活性,Pa2值为5.5至6.1.简单的烷基取代的2-[1-(1-(4-甲基和4-乙基)哌嗪基]类似物显示出中等的h3拮抗活性(pa2 = 6.0,Pa2 = 7.0).对于哌嗪基和六氢-1H-1,4-二氮杂-1-基同系物序列,具有4-苯基烷基取代基的化合物,无论苯环上对位取代基的物理化学性质如何,均表现出弱的h3-拮抗性pa2值介于4.4至5.6之间的活性.
Doi:10.1016/s0014-827X(99)00081-6

专利信息

专利号:CA-2731967-A1
优先权日:2008-08-15
标 题:Synthesis of cyclohexane derivatives useful as sensates in consumer products

专利号:CN-102123982-B
优先权日:2008-08-15
标题:Synthesis of cyclohexane derivatives useful as sensates in consumer products

专利号:CN-102123982-A
优先权日:2008-08-15
标题 :Synthesis of cyclohexane derivatives useful as sensates in consumer products

专利号:CA-2731967-C
优先权日:2008-08-15
标题:Synthesis of cyclohexane derivatives useful as sensates in consumer products

专利号:ES-2538789-T3
优先权日:2008-08-15
标 题 :Synthesis of cyclohexane derivatives useful as refreshing compounds in consumer products