CAS: 335280-19-8; (2R,3R)-1-(Tert-Butoxycarbonyl)-3-Hydroxypyrrolidine-2-Carboxylic Acid

英文名称(2R,3R)-1-(Tert-Butoxycarbonyl)-3-Hydroxypyrrolidine-2-Carboxylic Acid
中文名称(2R,3R)-1-(叔丁氧基羰基)-3-羟基吡咯烷-2-羧酸
IUPAC名称(2R,3R)-1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acid
其它别名(2R,3R)-3-羟基-1,2-吡咯烷二甲酸 1-叔丁酯; N-Boc-Trans-3-Hydroxy-D-Proline
CAS编号335280-19-8
MFCD编号:MFCD26406357
EINECS号:849-983-5
分子式:C10H17NO5分子量:231.25
产品CID: 1331382
产品分类有机原料→分子砌块→手性化合物→手性砌块

相似结构搜索
InChIKey: JLDHXHPQMBNKMC-RNFRBKRXSA-N
InChI=1S/C10H17NO5/c1-10(2,3)16-9(15)11-5-4-6(12)7(11)8(13)14/h6-7,12H,4-5H2,1-3H3,(H,13,14)/t6-,7-/m1/s1
计算化学: 氢键受体数4.0氢键供体数2.0可旋转键数1.0

相似化合物

118492-87-8 186132-96-7 184046-78-4

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

上下游产品

cis-3-hydroxy-DL-proline tert-butyl chloroformate (2R,3S)-3-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester cis-3-acetoxy-N-(tert-butoxycarbonyl)-D-proline(2S,3R)-1-[(tert-butoxy)carbonyl]-3-hydroxypyrrolidine-2-carboxylic acid 2-benzyl 1-(tert-butyl) (2R,3R)-3-fluoropyrrolidine-1,2-dicarboxylate methyl N-[(2S)-1-[(2R,3R)-3-hydroxy-2-{5-[4-(4-{2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl}phenyl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate

合成工艺路线路线简述

📜(2R,3R)-3-(Tert-Butyl-Diphenyl-Silanyloxy)-Pyrrolidine-1,2-Dicarboxylic Acid 1-Tert-Butyl Ester置于三氟乙酸体系中,用二氯甲烷用作溶剂,化学反应生成(2R,3R)-1-[(叔丁氧基)羰基]-3-羟基吡咯烷-2-羧酸
参考文献:Total Synthesis Of Cis-And Trans-3-Hydroxy-D-Proline And (+)-Detoxinine
标题:Total Synthesis Of Cis-And Trans-3-Hydroxy-D-Proline And (+)-Detoxinine
摘要:The Unnatural Enantiomer Of The Amino Acid Detoxinine And Both Diastereomeric 3-Hydroxy-D-Prolines Have Been Prepared From D-Mannitol Via The O-Silylated Hydroxyproline 12 As A Common Key Intermediate.
Doi:10.1021/jo951444U