CAS: 225-51-4; Benzo[c]Acridine
该化合物是一种多环芳烃(PAH),其特点是由多个芳香环组成的引信环状结构,以其成形结构为特征,以其平面几何测量法而著称,有助于其稳定性和与DNA相交的潜能;该化合物一般在室温下是固体,具有较高的熔点;本兹[c] 因其荧光特性而得到承认,使其对各种应用,包括有机电子和光体感兴趣;然而,也注意到其潜在的诱变性和致癌效应,引起人们对其环境和健康影响的关切;该化合物在水中溶剂溶解物中溶解性很差,但有机溶解剂中溶解性很强,影响其在生物系统和环境环境中的行为;由于其结构上与其他全氟辛烷化合物相似,它可能具有类似的代谢和毒性途径;与许多全氟辛烷化合物一样,乙烷在环境中的存在往往与不完全的燃烧过程有关,因此成为环境化学和毒理学的研究对象.
- 英文名称Benzo[c]Acridine
- 中文名称苯并[c]吖啶
- IUPAC名称benzo[c]acridine
- 其它别名3,4-Benzacridine; Benz[c]Acridine; Benzo(C)Acridine; 12-Azabenz(A)Anthracene; 3,4-Benzoacridine; 7,8-Benzacridine; 7,8-Benzacridine(French); Alpha-Chrysidine
- CAS编号225-51-4
- MFCD编号:MFCD00215933
- EINECS号:205-930-2
- FDA UNII编号:BV4376Y90X
- 分子式:C17H11N分子量:229.28
- 产品CID: 1163504
- 产品分类分析化学 → 标准品 → 挥发性有机原料(VOCs)
物理性质
- 熔点132 °C
- 沸点446.2±14.0 °C at 760 mmHg
- 闪点201.4±12.7 °C
- 密度1.2±0.1 g/cm3
- pKa:4.25±0.30(预测)
- PSA:12.89
- LogP:4.63
- 折射率1.783
- 蒸汽压0.0±1.0 mmHg at 25°C
- 溶解性Very slightly soluble in water
- 敏感性BENZ[C]ACRIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides.
- 外观形态苯/石油醚中析出的亮黄色针状物
- 储存条件2-8°C
- 产品应用该化合物用于化验检测细胞中受体调节潜力.
MSDS等安全信息
欧盟法规
ECHA物质ECHA物质C&L通报REACH预注册上下游产品
CAS号227803-21-6 2-苯基喹啉-3-甲醛 | CAS号823196-34-5 Benzenamine, N-... | CAS号446-52-6 邻氟苯甲醛 | CAS号77305-61-4 1,4,7,12-Tetrah... | CAS号90-11-9 1-溴代萘 | CAS号529-23-7 邻氨基苯甲醛 | CAS号78168-03-3 1,2,3,4,7,12-He... | CAS号563-63-3 乙酸银 | CAS号54538-09-9 ethyl (2-chloro... | CAS号78167-81-4 3,4-dihydrobenz...合成工艺路线路线简述
- 合成目标产物 Benzo(C)Acridine 主要起始原料 2-Naphthaldehyde
- (文献来源)合成步骤主要原料 2-Naphthaldehyde
📜2-甲基苯胺 盐酸盐置于lead(II) Oxide体系中,化学反应生成苯并(C)吖啶
参考文献:Ullmann; La Torre,Chemische Berichte,1904,Vol. 37,P. 2924
标题:Ullmann; La Torre,Chemische Berichte,1904,Vol. 37,P. 2924
海关参考信息
- 2902200000-苯
2902902000-精萘
2933310010-吡啶
2939800000-其他生物碱 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-10377784-B2
优先权日:2014-03-15
标 题 :Design, synthesis, and biological activity of platinum-benz[c]acridine hybrid agents and methods associated therewith
发明人：BIERBACH ULRICH; PICKARD AMANDA J
权利人:UNIV WAKE FOREST
摘要:The present invention relates to the compounds of formula (I), pharmaceutically acceptable salts, and solvates thereof, wherein the various substituents are as defined herein. The compounds, solvates and salts thereof of Formula (I) are effective as anti-cancer compounds.
专利号:EP-0617288-B1
优先权日:1993-03-19
标题 :Long emission wavelength chemiluminescent compounds and their use in test assays
发明人：LAW SAY-JONG; JIANG QINGPING; FISCHER WALTER; UNGER JOHN T; KRODEL ELIZABETH K
权利人:NOVARTIS AG; BAYER AG
摘要:An assay method incorporating at least two different chemiluminescent compounds for detection and/or quantitation of at least two substances in a test sample is described. The synthesis of chemiluminescent reagents or conjugates for use in such methods as well as kits incorporating such reagents are also disclosed. The assays have particular application in the field of clinical diagnostics.
专利号:US-2018319832-A1
优先权日:2014-03-15
标题:Design, Synthesis, and Biological Activity of Platinum-benz[c]acridine Hybrid Agents and Methods Associated Therewith
专利号:US-2017081351-A1
优先权日:2014-03-15
标题:Design, Synthesis, and Biological Activity of Platinum-benz[c]acridine Hybrid Agents and Methods Associated Therewith
专利号:US-10023599-B2
优先权日:2014-03-15
标题:Design, synthesis, and biological activity of platinum-benz[c]acridine hybrid agents and methods associated therewith
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Copper-Catalyzed N,N-Diarylation Of Amides For The Construction Of 9,10-Dihydroacridine Structure And Applications In The Synthesis Of Diverse Nitrogen-Embedded Polyacenes作者:Mei-Ling Tan,Shuo Tong,Sheng-Kai Hou,Jingsong You,Mei-Xiang Wang |发布日期:2020.7.17
摘要:Catalyzed N,N-Diarylation Reaction Of Amides With Various Di(O-Bromoaryl)Methanes To Produce Diverse 9,10-Dihydroacridine Derivatives. The Resulting 9,10-Dihydroacridine Derivatives Were Oxidized Selectively Under Mild Conditions To Afford Acridine, Acridinone, And Acridinium Derivatives. The Copper-Catalyzed N,N-Diarylation Reaction Coupled With Oxidative Aromatization Reaction Enabled The Facile Construction
合成参考文献
摘要:Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.). NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH) Publication No. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office, Jan. 1981., p. 6
摘要:Baxter CS, Warshaesky D; Patty's Toxicology. (1999-2013). New York, NY: John Wiley & Sons, Inc. Polycyclic Aromatic Hydrocarbons and Azaaromatic Compounds. On-line posting date: Aug 17, 2012.
摘要:U.S. Department of Health, Education Welfare, Public Health Service. Center for Disease Control, National Institute for Occupational Safety Health. NIOSH Manual of Analytical Methods. 2nd ed. Volumes 1-7. Washington, DC: U.S. Government Printing Office, 1977-present., p. V1 183-1
摘要:
摘要:Franke C et al; Chemosphere 29: 1501-14 (1994)
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