📜十二烷醇,(3Ar)-2-甲基-5Alpha-(乙酰氧基甲基)-6Beta,7Alpha-二乙酰氧基-3Aalpha,6,7,7Aalpha-四氢-5H-吡喃并[3,2-D]恶唑置于对甲苯磺酸体系中,用 1,2-二氯乙烷 用作溶剂,以82%的收率获得十二烷基-2,3,4,6-四-氧-乙酰基-β-D-吡喃氨基葡萄糖苷
参考文献:Synthesis And Protective Anti-Infective Action Of Anomeric Lipophilic Glycosides Of N-Acetylmuramyl-L-Alanyl-D-Isoglutamine
标题:Synthesis And Protective Anti-Infective Action Of Anomeric Lipophilic Glycosides Of N-Acetylmuramyl-L-Alanyl-D-Isoglutamine
摘要:Anomeric Pairs Of Alpha-And Beta-Dodecyl,Alpha-And Beta-(1-Pentylhexyl),And Alpha-And Beta-Cyclododecyl Glycosides Of N-Acetylmuramyl-L-Alanyl-D-Isoglutamine (Mdp) Were Synthesized. The Starting Beta-D-Glucosaminides Were Obtained By The Oxazoline Method,And The Corresponding Alpha-Isomers,By The Mercuric Iodide-Catalyzed Glycosylation Of Alcohols With Alpha-Glucosaminyl Chloride Peracetate In Nitromethane At-90 Degrees C. No Reliable Differences Between The Stimulation Of Mouse Resistance To The Infection With Staphylococcus Aureus (Doses Of 2,20,And 200 Mu G/mouse) And Escherichia Coli (Doses Of 0.05,1,And 20 Mu G/mouse) With The Mdp Alpha-And Beta-Glycosides Were Found.
Doi:10.1134/s1068162006040091