CAS: 20336-15-6; 2,4,6-Tri-Tert-Butylpyridine

该化合物是受到严格阻碍的衍生物,其特点是在2,4和6个位置上存在三个基丁基组,这种结构特征对致命的致命性攻击具有特别的抗药性,使它在有机合成中成为宝贵的非核生殖基础,其高度的阻力最大限度地减少了不必要的侧面反应,特别是在酸催化过程中,传统基可能干扰.该化合物在协调化学和聚合反应中也被用作稳定剂,其基础性低,并且具有很强的性能,因此适合在苛刻条件下需要选择性脱氧或质子分离的应用.

结构式图片

相似化合物

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上下游产品

tert-butyl is°Cyanide 3,3-Dimethylbut-1-yne (2,6-diisopropylphenoxy)2Cl(tantalum)(η2-(N,C)-2,4,6-tri-tert-butylpyridine) 3)2CH)2C6H3O)2Cl(Ta(C(C(CH3)3)CHCHC(C(CH3)3)))(((CH3)2CH)2C6H3O)2Cl(Ta(C(C(CH3)3)CHCHC(C(CH3)3))) 6F5)3][(2,4,6-tri-tert-butylpyridineH)][HB(C6F5)3] 2B(C6F5)]2[H2B(C6F5)]2

合成工艺路线路线简述

    📜三甲基乙腈置于pyridine-N-Oxide体系中,用 正戊烷 用作溶剂,化学反应生成2,4,6-三叔丁基吡啶
    参考文献:Strickler,Jamie R.; Bruck,Michael A.; Wigley,David E.,Journal Of The American Chemical Society,1990,Vol. 112,# 7,P. 2814-2816
    标题:Strickler,Jamie R.; Bruck,Michael A.; Wigley,David E.,Journal Of The American Chemical Society,1990,Vol. 112,# 7,P. 2814-2816

    海关参考信息

    专利信息


    专利号:US-8318427-B2
    优先权日:2005-12-29
    标 题 :Use of acid scavengers for the synthesis of standard length and long-mer nucleic acid arrays
    发明人:KUIMELIS ROBERT G; MCGALL GLENN H; GOLDBERG MARTIN J; XU GUANGYU
    权利人:KUIMELIS ROBERT G; MCGALL GLENN H; GOLDBERG MARTIN J; XU GUANGYU; AFFYMETRIX INC
    摘要:Protective groups which may be cleaved with an activatable deprotecting reagents are employed to achieve a highly sensitive, high resolution, combinatorial synthesis of pattern arrays of diverse polymers. In preferred embodiments of the instant invention, the activatable deprotecting reagent is a photoacid generator and the protective groups are DMT for nucleic acids and tBOC for amino acids. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers.

    专利号:US-2002147331-A1
    优先权日:2001-02-02
    标题:Methods for synthesis of oligonucleotides
    发明人:GUZAEV ANDREI P; MANOHARAN MUTHIAH
    摘要:The present invention is directed to improved methods and compositions for synthesis of oligonucleotides and other phosphorus-linked oligomers, without the need for phosphoryl protecting groups. The methods involve the reaction of nucleoside phosphoramidites with a support-bound oligomer having one or more unprotected phosphorus-containing internucleoside linkages in the presence of a neutralizing agent.

    专利号:US-8258199-B2
    优先权日:2006-01-18
    标题:Photoacid generators for the synthesis of oligo-DNA in a polymer matrix
    发明人:MCGALL GLENN H; CUPPOLETTI ANDREA
    权利人:MCGALL GLENN H; CUPPOLETTI ANDREA; AFFYMETRIX INC
    摘要:Compounds represented by the following structural formulas can be used as photoacid generators: n n n n n n n n n n Such compounds are useful, for example, in fabricating arrays of polymers.

    专利号:US-10328141-B2
    优先权日:2013-07-07
    标题:Synthetic vaccines against Streptococcus pneumoniae type 1
    发明人:SEEBERGER PETER H; PEREIRA CLANEY LEBEV; ANISH CHAKKUMKAL; SCHUMANN BENJAMIN
    权利人:MAX PLANCK GESELLSCHAFT
    摘要:The present invention relates to the total synthesis of saccharide structures contained in the capsular polysaccharide of Streptococcus pneumoniae type 1, to glycoconjugates containing said saccharide structures obtained by total synthesis and to use of such glycoconjugates and pharmaceutical compositions thereof in the immunization against diseases associated with bacteria containing said saccharide structures in their capsular polysaccharide, and more specifically associated with Streptococcus pneumoniae.

    专利号:US-11629162-B2
    优先权日:2015-12-17
    标 题:Triterpene saponin variants, methods of synthesis and use thereof
    发明人:TAN DEREK S; GIN DAVID Y; WALKOWICZ WILLIAM E; FERNANDEZ-TEJADA ALBERTO; RAGUPATHI GOVINDASWAMI
    权利人:MEMORIAL SLOAN KETTERING CANCER CENTER
    摘要:A number of triterpene saponin variants with different modifications on their central glycosyl ester linkage are described. Also described are methods of making and method of using such triterpene saponin variants.

    专利号:EP-3357931-B1
    优先权日:2008-04-08
    标 题:Methods of synthesis of triterpene prosapogenins and triterpene saponins

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Y Endo, Et Al. [参考文献]: Josanpu Zasshi. 1978 Jan;32(1):55.

    合成参考文献


    摘要:Demchenko, A. V.; De Meo, C., Science of Synthesis Knowledge Updates, (2010) 3, 239.
    摘要:Chemler, S. R.; Wdowik, T., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 364.
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