CAS: 18720-35-9; 4-(Methoxycarbonyl)Bicyclo[2.2.2]Octane-1-Carboxylic Acid

上下游产品

双环[2.2.2]辛烷-1,4-二羧酸二甲酯 Dimethyl Bicyclo[2.2.2]Octane-1,4-Dicarboxylate 1459-96-7
1-(2-氯乙基)环己烷-1,4-二羧酸二甲酯 Dimethyl 1-(2'-Chloroethyl)Cyclohexane-1,4-Dicarboxylate 106004-06-2
1,4-环己烷二羧酸二甲酯 Dimethyl 1,4-Cyclohexane Dicarboxylate 94-60-0
1,4-环己烷二甲酸 Cyclohexane-1,4-Dicarboxylic Acid 1076-97-7
2,5-二氧代双环[2.2.2]辛烷-1,4-二羧酸二甲酯 Dimethyl 2,5-Dioxobicyclo[2,2,2]Octane-1,4-Dicarboxylate 57293-62-6
Dimethyl Bicyclo[2.2.2]Oct-2-Ene-1,4-Dicarboxylate 1659-67-2

Dimethyl 2,5-Bi<1,3>Dithiolanylbicyclo<2.2.2>octane-1,4-Dicarboxylate置于raney Nickel-W2 氢氧化钾,乙醇体系中,用 甲醇,水 用作溶剂,化学反应 120.0H,反应生成4-(甲氧羰基)双环[2.2.2]辛烷-1-羧酸
参考文献:Rodlike Molecules By Kolbe Electrolysis
标题:Rodlike Molecules By Kolbe Electrolysis
摘要:描述了一种新的简短且简单的方法,以获得刚性,棒状的碳氢骨架,特别是寡碱基[2.2.2]八烷类型.关键步骤是二环和三环羧酸的桥头位置之间的电化学c-C键偶联反应.功能团可以保留,并且它们会影响c-C键连接的收率.通过这种方法,以往难以或繁琐的合成过程得以缩短,同时刚性,不可崩溃的纳米级间隔单元也变得容易获取.优化后的电化学程序进行了详细描述.
Doi:10.1055/s-1996-4152

专利信息

专利号:US-2025011313-A1
优先权日:2021-10-28
标 题:Ccr6 receptor modulators
发明人：ALLEMANN OLIVER; HUBLER FRANCIS; MEYER EMMANUEL
权利人:IDORSIA PHARMACEUTICALS LTD
摘要:The present invention relates to compounds of Formula (I), their synthesis and use as CCR6 receptor modulators for the prevention or treatment of e.g. inflammatory/autoimmune diseases/disorders and cancer.