5-氨基-2-萘磺酸置于盐酸,Sodium Nitrite体系中,化学反应生成对氨基苯磺酸 参考文献:Polarizing Film,Image Display Device,And Method For Producing Polarizing Film 标题:Polarizing Film,Image Display Device,And Method For Producing Polarizing Film 摘要:本发明提供了一种具有高二向比的偏光膜.该偏光膜包含下列一般式(1)所代表的二氮基化合物.在一般式(1)中,Q1代表至少一个-so3M基团的苯基;Q2代表至少一个-so3M基团的萘基;X代表具有1至4个碳原子的烷基基团,具有1至4个碳原子的烷氧基团,具有1至4个碳原子的硫代烷基基团,卤素基团或极性基团;下标k表示x的取代数,表示一个介于0至5之间的整数;M代表一个计数离子,在k为2或更多的整数时,Xs为相同或不同.
专利信息
专利号:WO-2024260325-A1 优先权日:2023-06-19 标题 :Synthesis of macrocyclic compound and medical use of macrocyclic compound 发明人:LU HONGFU; DING XIAO; REN FENG 权利人:INSILICO MEDICINE IP LTD 摘要:Provided in the present invention are the synthesis of a macrocyclic compound and the medical use of the macrocyclic compound. Specifically, provided in the present invention are a compound as show in formula (II), a stereoisomer thereof or a pharmaceutically acceptable salt thereof, which can be used as a CDK7 inhibitor.
专利号:US-7951961-B2 优先权日:2006-07-07 标题:Enantioselective synthesis of pyrrolidines substituted with flavones, and intermediates thereof 发明人:SIVAKUMAR MEENAKSHI; SHUKLA MANOJ; JADHAV PRAMOD KUMAR; BORHADE AJIT 权利人:PIRAMAL LIFE SCIENCES LTD 摘要:The present invention relates to an enantioselective synthesis of (+)-trans enantiomer of pyrrolidines substituted with flavones, represented by Formula 1 or salts thereof, which are inhibitors of cyclin dependant kinases and can be used for treatment of proliferative disorders such as cancer n nwherein Ar has the meaning as indicated in the claims.
专利号:US-7767826-B2 优先权日:2007-10-05 标题 :Process for the synthesis of L-(+)-ergothioneine 发明人:TRAMPOTA MIROSLAV 权利人:PHARMATECH INTERNATIONAL INC 摘要:This invention relates to a novel process for the preparation of optically pure L-(+)-ergothioneine. The process for the chemical synthesis of L-ergothioneine comprises steps which consist of reacting L-histidine alkyl ester with an acid halide, chloroformate or pyrocarbonate in the presence of a base, hydrolysis of the alkyl-(S,Z)-2,4,5-triamidopent-4-enoate to obtain a (S)-alkyl 2,5-diamido-4-oxopentanoate, acid catalyzed hydrolysis of the (S)-alkyl 2,5-diamido-4-oxopentanoate followed by reaction with a metal thiocyanate to obtain the thiohistidine, protection of the sulfur of thiohistidine as the tert-butyl thioether, dialkylation of the primary amine to obtain a tertiary amine, quaternization of the tertiary amine, and removal of the protecting group to obtain the desired (S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trialkylammonio)propanoate (I). This process affords a better yield and is capable of practical application at large scale.
专利号:US-10604479-B2 优先权日:2013-11-18 标 题:Continuous process for the one-pot synthesis of metal salts and metal complexes 发明人:LEONARDI GIULIANO; GASPERONI GIOVANNI 权利人:VOLARE & CONNECTING LLC; LEONARDI GIULIANO; NOVUS INT INC 摘要:A continuous process is described for the one-pot synthesis of compounds, such as metal salts and metal complexes, as well as optionally for the protection of the compounds thus obtained by coating and/or impregnation with suitable compounds.
专利号:EP-2690438-A1 优先权日:2012-07-24 标题:Synthesis of diverse glycosylphosphatidylinositol glycans and glycolipids from toxoplasma gondii and their application as diagnostic markers and vaccines 发明人:AZZOUZ NAHID; GOETZE SEBASTIAN; SEEBERGER PETER H; SILVA DANIEL VARON; TSAI YU-HSUAN 权利人:MAX PLANCK GESELLSCHAFT 摘要:The present invention relates to the synthesis of compounds derived from glycosylphosphatidylinositol (GPI) glycolipids from Toxoplasma gondii and the resulting products obtained. These synthetic compounds are suitable for diagnosis of toxoplasmosis and for use as a vaccine against diseases caused by infection with T. gondii.
专利号:US-9802974-B2 优先权日:2012-07-24 标 题 :Synthesis of diverse glycosylphosphatidylinositol glycans from Toxoplasma gondii and their application as vaccines and diagnostics 发明人:AZZOUZ NAHID; GÖTZE SEBASTIAN; SEEBERGER PETER H; SILVA DANIEL VARON; TSAI YU-HSUAN 权利人:MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V 摘要:The present invention relates to the synthesis of GPI-related surface antigens of the parasite Toxoplasma gondii ( T. gondii ) and the resulting products obtained. These synthetic compounds are suitable for diagnosis of toxoplasmosis, as well as vaccine against toxoplasmosis, a diseases caused by infection with T. gondii.
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合成参考文献
参考文献:10.1107/s160053681100746x 摘要:Lu Y, Li X, Bing Y, Zha M, Li Y. Bis(1,10-phenanthroline-κ2N,N′)[2-(4-sulfonatoanilino)acetato-κO]copper(II) dihydrate. Acta Crystallogr E Struct Rep Online. 2011 Mar 09;67(4):m402–3. doi: 10.1107/s160053681100746x.