CAS: 1111-39-3; 3'''-O-Acetyldigitoxin

上下游产品

pyridine digitoxin 3',4'-di-O-acetyl digitoxin D-digitoxose Digitoxigenin digitoxin 3-dehydrodigoxigenin

📜3"',4"'-Di-O-Acetyl Digitoxin置于水,Potassium Carbonate体系中,用 甲醇 用作溶剂,化学反应生成2-乙酰氨基-1,2,5-三脱氧-1,5-亚氨基-D-葡萄糖醇
参考文献:Perfectly Regioselective Acylation Of A Cardiac Glycoside,Digitoxin,Via Catalytic Amplification Of The Intrinsic Reactivity
标题:Perfectly Regioselective Acylation Of A Cardiac Glycoside,Digitoxin,Via Catalytic Amplification Of The Intrinsic Reactivity
摘要:Organocatalytic Regioselective Acylation Of Digitoxin Has Been Developed. This Method Provides The 4'''-O-Manoacylate As The Sole Product Without The Concomitant Formation Of Diacylates. The Extremely High Regioselectivity Was Assumed To Be The Result From The Combined Effects Of The High Intrinsic Reactivity Of C(4''')-Oh And Catalyst-Promoted Regioselective Acylation Of The Same Hydroxy Group. (C) 2010 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tetlet.2010.07.036

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-10814013-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:US-6699676-B1
优先权日:1999-06-03
标题:Uses of ouabain and ouabain-like molecules in apoptosis related pathologies
发明人：ORLOV SERGEI N; HAMET PAVEL; TREMBLAY JOHANNE
权利人:CORP DU CT DE RECH DU CT HOSPI
摘要:Longterm elevation of the intracellular Na + /K + ratio inhibits macromolecule synthesis and proliferation in the majority of cell types studied so far, including vascular smooth muscle cells (VSMC). We report here that inhibition of the Na + ,K + pump in VSMC by ouabain or 1 hour preincubation in K + -depleted medium attenuated apoptosis triggered by serum withdrawal, staurosporine or okadaic acid. In the absence of ouabain, both DNA degradation and caspase-3 activation in VSMC undergoing apoptosis were insensitive to modification of the extracellular Na + /K + ratio as well as to hyperosmotic cell shrinkage. In contrast, protection of VSMC from apoptosis by ouabain was abolished under equimolar substitution of Na + o with K + o , showing that the anti apoptotic action of Na + ,K + pump inhibition was caused by inversion of the intracellular Na + /K + ratio. Unlike VSMC, the same level of increment of the [Na + ] i /[K + ] i ratio caused by 2 hours preincubation of Jurkat cells with ouabain did not affect chromatin cleavage and caspase-3 activity triggered by treatment with Fas ligand, staurosporine or hyperosmotic shrinkage. Thus, our results show for the first time that similarly to cell proliferation, maintenance of a physiologically low intracellular Na + /K + ratio is required for progression of VSMC apoptosis.

专利号:AU-2007308022-A2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:AU-2007308022-A1
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:US-2008107598-A1
优先权日:2006-10-05
标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications