CAS: 10547-88-3; 4-Isopropyldihydrofuran-2(3H)-One

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3-Isopropylsuccinic Anhydride 49538-78-5
3-(Acetoxymethyl)-4-Methylpentanoic Acid 80410-21-5
4-I-Butyldihydrofuran-2(3H)-One 181289-09-8
2-Isopropylbernsteinsaeure-4-Ethylester 32980-53-3
2-Isopropylbernsteinsaeure-1-Aethylester 21201-84-3
3-Carbonyl-4-Isopropyl-4,5-Dihydrofuran-2(3H)-One 96540-44-2
5-Ethoxy-4-Isopropyl-Dihydro-Furan-2-One 78920-26-0

📜5-Hydroxy-4-Isopropylfuran-2(5H)-One置于palladium On Activated Charcoal Sodium Tetrahydroborate,氢气体系中,用 甲醇 用作溶剂,化学反应 5.0H,反应生成3-异丙基-4-丁内酯
参考文献:Analogs Of .Gamma.-Hydroxybutyric Acid. Synthesis And Binding Studies
标题:Analogs Of .Gamma.-Hydroxybutyric Acid. Synthesis And Binding Studies
摘要:Substituted 4-Hydroxybutyric (Ghb) Or Trans-4-Hydroxycrotonic Acids (T-Hca) And Structurally Related Compounds Were Synthesized And Submitted To [3H]Ghb Binding. Structure-Activity Relationships Studies Highlighted For [3H]Ghb Binding (A) The Necessity Of A Nonlactonic,Relatively Extended Conformation Of The Gamma-Hydroxybutyric Chain,(B) The Existence Of Some Bulk Tolerance In The Vicinity Of The Hydroxyl Group,And (C) The High Sensitivity Toward Isosteric Replacements Of The Carboxyl Or The Hydroxyl Groups. T-Hca Has Been Recently Identified As A Naturally occurring Substance In The Central Nervous System (Cns) And Shows A Better Affinity Than Ghb. Our Findings Are In Favor Of The Presence In The Cns Of Specific Ghb Binding Sites,Which Are Different From The Gaba And The Picrotoxin Binding Sites,And For Which T-Hca May Be An Endogenous Ligand.
Doi:10.1021/jm00400A001