CAS: 104992-55-4; (2R,3R,4R,5R)-5-(6-Benzamido-9H-Purin-9-yl)-2-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-4-((Tert-Butyldimethylsilyl)Oxy)Tetrahydrofuran-3-Yl (2-Cyanoethyl) Diisopropylphosphoramidite

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上下游产品

CAS号102691-36-1 双(二异丙基氨基)(2-氰基乙氧基)膦 | CAS号129681-71-6 2'-O-tert-butyl...

N6-苯甲酰基腺苷置于吡啶,4-二甲氨基吡啶,Silver Nitrate,三乙胺,N,N-二异丙基乙胺体系中,用 二氯甲烷 用作溶剂,化学反应 19.0H,反应生成N-苯甲酰基-5'-O-(4,4-二甲氧基三苯甲基)-2'-O-[(叔丁基)二甲基硅基]腺苷-3'-(2-氰基乙基-N,N-二异丙基)亚磷酰胺
参考文献: Cyclic Di-Nucleotide Compounds And Methods Of Use[fr] Composés Di-Nucléotides Cycliques Et Leurs Procédés D'Utilisation
标题: Cyclic Di-Nucleotide Compounds And Methods Of Use[fr] Composés Di-Nucléotides Cycliques Et Leurs Procédés D'Utilisation
摘要:揭示了环二核苷酸cgamp类似物,合成这些化合物的方法,包括这些化合物的药物组合物,以及在医学治疗中使用这些化合物和组合物的用途.

专利信息

专利号:US-10730904-B2
优先权日:2012-11-14
标 题:Method for liquid-phase synthesis of nucleic acid
发明人：NONOGAWA MITSURU; NAGATA TOSHIAKI; SAITO HIDEKI; YASUMA TSUNEO
权利人:TAKEDA PHARMACEUTICALS CO
摘要:In this method, an oligonucleotide represented by formula (II) [wherein Y 1 , Q, Base, r and r′ are each as defined in claim 1 ] is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R 1 , Y, Base, Z, Ar, R 2 , R 3 and n are each as defined in claim 1 ]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method can dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3′-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.

专利号:US-2005059817-A1
优先权日:2000-09-01
标题 :Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives
发明人：BEIGELMAN LEONID; KARPEISKY ALEXANDER; SEREBRYANY VLADMIR; HAEBERLI PETER; SWEEDLER DAVID
权利人:SIRNA THERAPEUTICS INC
摘要:The present invention provides methods for the chemical synthesis of nucleosides and derivatives thereof, including 2′-amino, 2′-N-phthaloyl, 2′-O-methyl, 2′-0-silyl, 2′-O-triisopropylsilyloxymethyl, 2′-OH nucleosides, C-nucleosides, nucleoside phosphoramidites, C-nucleoside phosphoramidites, and non-nucleoside derivatives.

专利号:US-2015315229-A1
优先权日:2012-11-14
标 题 :Method for liquid-phase synthesis of nucleic acid

专利号:US-10214555-B2
优先权日:2012-11-14
标题 :Method for liquid-phase synthesis of nucleic acid

专利号:US-2019135852-A1
优先权日:2012-11-14
标题 :Method for liquid-phase synthesis of nucleic acid

专利号:EP-2921499-A1
优先权日:2012-11-14
标 题 :Method for liquid-phase synthesis of nucleic acid