专利号:US-4026911-A 优先权日:1976-02-23 标 题:Process for the preparation of ketoalkynoic acids and use of the process in an improved synthesis of 2-(substituted)-cyclo-pentane-1,3,4-triones 发明人:REVERMAN LAWRENCE FRANCIS 权利人:MILES LAB 摘要:Reaction of a 2-methyl-2-(alkenyl)-1,3-dioxolane with an α,ω-dihalogenoalkane to obtain a 2-methyl-2-(ω-chloroalkynyl)-dioxolane, conversion of the latter to a corresponding nitrile, and hydrolysis of the nitrile to form a ketoalkynoic acid is a novel process for preparing the acid. n Use of the process in the synthesis of 2-(substituted)-cyclopentane-1,3,4-triones improves that synthesis.
专利号:WO-2024182268-A1 优先权日:2023-02-27 标 题 :Liquid phase peptide support synthesis of peptides and peptidomimetics 发明人:HAN AMY 权利人:REGENERON PHARMA 摘要:The present invention provides compounds useful as support for liquid phase organic synthesis e.g., liquid phase organic synthesis of peptides and peptidomimetics. In one aspect, the present invention provides a compound having a structure of Formula (I) where R1, R2, R3, m, and n are as described herein and methods of making and using same.
专利号:US-5948789-A 优先权日:1994-07-15 标题:Process for synthesis of substituted sulphoxides 发明人:LARSSON MAGNUS ERIK; STENHEDE URBAN JAN; SOERENSEN HENRIK; VON UNGE SVERKER PER OSKAR; COTTON HANNA KRISTINA 权利人:ASTRA AB 摘要:PCT No. PCT/SE95/00818 Sec. 371 Date Jul. 14, 1995 Sec. 102(e) Date Jul. 14, 1995 PCT Filed Jul. 3, 1995 PCT Pub. No. WO96/02535 PCT Pub. Date Feb. 1, 1996A novel process for enantioselective synthesis of single enantiomers of omeprazole or its alkaline salts, of other optically pure substituted 2-(2-pyridinylmethyl-sulphinyl) -1H-benzimidazoles as well as of other structurally related sulphoxides or their alkaline salts. The claimed process is an asymmetric oxidation of a pro-chiral sulphide to the single enantiomers or an enantiomerically enriched form of the corresponding sulphoxide. The application also claims the enantiomeric sulphoxide products produced by the process and their use in medicine.
专利号:US-9371334-B2 优先权日:2010-09-22 标题:Synthesis of substituted salicylaldehyde derivatives 发明人:FARMER JAY J; JOB GABRIEL E 权利人:NOVOMER INC 摘要:Among other things, the present invention encompasses methods of synthesizing salicylaldehyde derivatives comprising the steps of: a) providing salicylaldehyde or a derivative thereof, b) forming an anhydro dimer of the provided salicylaldehyde compound, c) performing one or more chemical transformations on the anhydro dimer and d) hydrolyzing the anhydro dimer to provide a salicylaldehyde derivative different from that provided in step (a).
专利号:US-7288655-B2 优先权日:2003-03-07 标 题 :α v integrin receptor antagonists 发明人:BISHOP BRIAN CHRISTOPHER; BRANDS KAREL MARIE JOSEPH; COTTRELL IAN FRANK; COWDEN CAMERON JOHN; DAVIES ANTONY JOHN; KEEN STEPHEN PHILIP; LIEBERMAN DAVID ROSS; STEWART GAVIN WILLIAM 权利人:MERCK SHARP & DOHME 摘要:The present invention relates to the synthesis of intermediates for the preparation of compounds of formula (A): wherein n is 2 or 3 and various salt forms of these compounds. The compounds of formula (A) are useful as ανβ3 receptor antagonists
专利号:US-8067460-B2 优先权日:2004-10-04 标 题 :5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated Kv1.3 potassium channel 发明人:WULFF HEIKE; SANKARANARAYANAN ANANTHAKRISHNAN; HAENSEL WOLFRAM; SCHMITZ ALEXANDER; SCHMIDT-LASSEN KRISTINA 权利人:WULFF HEIKE; SANKARANARAYANAN ANANTHAKRISHNAN; HAENSEL WOLFRAM; SCHMITZ ALEXANDER; SCHMIDT-LASSEN KRISTINA; UNIV CALIFONIA 摘要:Compositions of matter comprising 5-phenoxyalkoxypsoralen compounds and their method of synthesis and use. The compounds are useable to treat diseases or disorders in human or animal subjects, including autoimmune diseases. The compounds inhibit potassium channels, including the Kv1.3 channel and at least some of the therapeutic effects of such compounds may be due at least in part to potassium channel inhibition. In some embodiments, the compounds are more selective for certain potassium channels (e.g., Kv1.3 channels) than other potassium channels (e.g., Kv1.5 channels).
参考标题:The Asymmetric Synthesis Of Amines Via Nickel-Catalyzed Enantioconvergent Substitution Reactions 作者:Ze-Peng Yang,Dylan J. Freas,Gregory C. Fu |发布日期:2021.2.24 摘要:Dialkyl Carbinamines Do Not Provide General Access To Amines Wherein The Two Alkyl Groups Are Of Similar Size (E.G., Ch2R Versus Ch2R1). Herein, We Report Two Mild Methods For The Catalytic Enantioconvergent Synthesis Of Protected Dialkyl Carbinamines, Both Of Which Use A Chiral Nickel Catalyst To Couple An Alkylzinc Reagent (1.1-1.2 Equiv) With A Racemic Partner, Specifically, An α-Phthalimido Alkyl Chloride
合成参考文献
摘要:Koutentis, P. A.; Ioannidou, H. A., Science of Synthesis Knowledge Updates, (2010) 1, 370. 摘要:Wolf, C., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 875.