CAS: 1028-33-7; 1-Hexyl-3,7-Dimethyl-1H-Purine-2,6(3H,7H)-Dione

相似化合物

6493-06-7 74409-52-2 31542-63-9

上下游产品

CAS号83-67-0 可可碱 | CAS号111-25-1 1-溴代正己烷 | CAS号544-10-5 氯(代)正己烷

📜1-(5-Isocyanohexyl)-3,7-Dimethyl-3,7-Dihydro-1H-Purine-2,6-Dione置于2-甲基十一烷-2-硫醇,(1,3-Dimethylimidazol-2-Ylidene)Borane,[ir(Df(Cf3)Ppy)2(Dtbbpy)](Pf6),Sodium T-Butanolate体系中,用 甲基叔丁基醚 用作溶剂,以50 %的收率获得1-正-己基可可碱
参考文献:通过异腈加氢脱氰化进行脱氨和脱氧的统一方法:实验和计算相结合的研究
标题:通过异腈加氢脱氰化进行脱氨和脱氧的统一方法:实验和计算相结合的研究
摘要:我们报告了使用异腈中间体的通用加氢脱官能化方案.利用光氧化还原催化作用,亲核硼基自由基介导相对惰性的 C−nc 键的断裂,从而实现异腈基团的删除.该策略适用于含胺和醇化合物的加氢脱官能化,并延伸至羰基,烯烃和烷基腈的还原.
Doi:10.1002/anie.202405779

专利信息

专利号:US-2015283095-A1
优先权日:2012-11-16
标 题:Nanoparticles with biodegradable and biocompatible polymer plga, loaded with the drug for human use pentoxifylline
发明人：CONSTANDIL CÓRDOVA LUIS ERNERTO; IBARRA DURà N PAULA SOLEDAD; VILOS ORTIZ CRISTIAN ANDRES; VELà SQUEZ CUMPLIDO LUIS; PELISSIER SERRANO TERESA; LAURIDO FUENZALIDA CLAUDIO AURELIO; HERNà NDEZ KUNSTMANN ALEJANDRO
权利人:UNIV SANTIAGO CHILE
摘要:The invention relates to a novel pharmaceutical formulation comprising polymer nanoparticles of the biodegradable and biocompatible polymer poly(lactic-glycolic) acid (PLGA), loaded with the drug pentoxifylline, the method for the synthesis of the PLGA nanoparticles loaded with pentoxifylline, and to the use thereof in the effective treatment for the relief of chronic pain and for the prevention of chronic pain via the administration of a single dose.

专利号:US-8354116-B2
优先权日:2007-06-18
标题 :Bifunctional synthetic molecules
发明人：CARTER STEPHEN G; PATEL KANU; ZHU ZHEN; QIAO LIXIN
权利人:BIOCHEMICS INC; CARTER STEPHEN G; PATEL KANU; ZHU ZHEN; QIAO LIXIN
摘要:The synthesis and use of bifunctional molecules to improve the topical and transdermal delivery efficiency of various types of therapeutic agents or agents designed to promote the transdermal delivery of those therapeutic agents either into the skin tissue or into the systemic circulation. Three major classes of molecules are covalently joined as bifunctional substances; chemical vasodilators, passive dermal penetration enhancers and therapeutic or diagnostic drugs. Chemical vasodilators may be delivered into the skin to increasing the blood flow in a tissue that has compromised circulation or they may be used as part of a delivery vehicle to promote the delivery of the drug. Passive dermal penetration enhancers are those chemicals that promote the passive penetration of drugs and other chemicals through the stratum corneum and epidermis of the skin tissue. Drugs and diagnostic agents are the third group of chemicals that are candidates for the linkage of molecules.