CAS: 930-27-8; 3-Methylfuran

该化合物是一种有机化合物,其特点是五人组成的芳香环结构,内含一个氧原子和附于呋喃环第三个碳的甲基组;它是室内温度无色液体,有独特的甜味,焦糖味的香味;该化合物以其相对较低的沸点和水中的中溶解性而闻名,使其在有机溶剂中更易溶解;3-甲基乙呋喃是易燃的,应当谨慎处理,因为它若吸入或摄取,可能会对健康造成危害;它主要用作溶剂和有机合成的中间体,特别是在生产各种化学品和药品方面;此外,由于具有有利的特性,包括高能量含量和与现有燃料基础设施的兼容性,它作为潜在的生物燃料引起了兴趣;它的耐受力使它得以参与各种化学反应,包括聚合和氧化,使其在工业和研究应用中成为多用途化合物.

结构式图片

相似化合物

498-60-2 67364-02-7 3710-43-8

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

3-糠醛 Furan-3-Carboxaldehyde 498-60-2

合成工艺路线路线简述

  • 合成目标产物 3-Methylfuran 主要起始原料 3-Methyl-2-Furoic Acid
  • 4412-96-8 = 930-27-8
    反应条件:1.1 Catalysts: Copper Solvents: Quinoline; 250 °C
    标题:Quinoline
    作者:Sherman,Angela R.; Caron,Antoine; Collins,Shawn K.
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2015 卷标:1 页码:1-4]

    153681-93-7 = 930-27-8
    反应条件:1.1 Catalysts: Trifluoroacetic Acid
    标题:Synthesis And Ene Reactions Of 3-Methylene-2,3-Dihydrofuran
    作者:Miles,William H.; Berreth,Christina L.; Smiley,Patricia M.
    参考文献:Tetrahedron Letters 日期:1993 卷标:34(33) 页码:5221-2]

    61842-14-6 = 930-27-8 [标题:Reaction Conditions
    标题:A Convenient Synthesis Of Furans
    作者:Camus,Francis; Hasiak,Bruno; Martin,Marius; Couturier,Daniel
    参考文献:Synthetic Communications 日期:1982 卷标:12(8) 页码:647-50]

    4090-48-6 = 930-27-8
    反应条件:1.1 Reagents: Sulfuric Acid,Mercuric Sulfate
    标题:Synthesis Of Furans From Acetylenic Epoxides And Diols
    作者:Miller,David
    参考文献:Journal Of The Chemical Society [section] C: Organic 日期:1969 卷标:(1) 页码:12-15]

    82698-68-8 = 930-27-8 [标题:Reaction Conditions
    标题:Photochemistry Of 3,6-Dihydro-1,2-Oxazines: A Versatile Route To Substituted Pyrroles
    作者:Givens,R. S.; Choo,D. J.; Merchant,S. N.; Stitt,R. P.; Matuszewski,B.
    参考文献:Tetrahedron Letters 日期:1982 卷标:23(13) 页码:1327-30]

    955998-81-9 = 930-27-8 [标题:Reaction Conditions
    标题:Product Class 9: Furans
    作者:Koenig,B.
    参考文献:Science Of Synthesis 日期:2002 卷标:9 页码:183-285]

    534-22-5 = 930-27-8 [标题:Reaction Conditions
    标题:Photoisomerization Of 2-Alkylfurans To 3-Alkylfurans
    作者:Hiraoka,H.; Srinivasan,R.
    参考文献:Journal Of The American Chemical Society 日期:1968 卷标:90(10) 页码:2720-1]

    = 930-27-8 [标题:Reaction Conditions
    标题:Carbohydrate Pyrolysis Mechanisms From Isotopic Labeling
    作者:Paine,John B. Iii; Pithawalla,Yezdi B.; Naworal,John D.
    参考文献:Journal Of Analytical And Applied Pyrolysis 日期:2008 卷标:83(1) 页码:37-63]

    4412-96-8 = 930-27-8
    反应条件:1.1 Reagents: Copper Solvents: Quinoline
    标题:3-Methyl-2-Furoic Acid And 3-Methylfuran
    作者:Burness,D. M.
    参考文献:Organic Syntheses 日期:1959 卷标:39 页码:46-8]

    4412-91-3 = 930-27-8
    反应条件:1.1 Catalysts: P-Toluenesulfonic Acid,Titania,Palladium,Bis(Acetonitrile)Dichloro- (Supported On Tio2) Solvents: Methanol; 18 H
    标题:Process For The Preparation Of Organic Compounds Via Reduction Of Allylic Compounds
    参考文献:Japan]

    = 930-27-8
    反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Molybdenum,[[2,2′-[1,2-Ethanediylbis[(Nitrilo-Kn)Methylidyne]]Bis[phenolato-Ko]... Solvents: Benzene; 6 H,40 °C
    标题:Process For Preparation Of 3-Methylfuran
    参考文献:China]

    498-60-2 = 930-27-8 [标题:Reaction Conditions
    标题:Orientation In The Furan Nucleus. Vi. β-Substituted Furans
    作者:Gilman,Henry; Burtner,Robert R.
    参考文献:Journal Of The American Chemical Society 日期:1933 卷标:55 页码:2903-9]

    4412-96-8 = 930-27-8
    反应条件:1.1 Reagents: Quinoline Catalysts: Copper; 2.5 H,165 - 180 °C
    标题:[4+3] Cycloaddition Of C-3 Substituted Furans. Stereoselectivity Induced By Coordination Effects
    作者:Montana,Angel M.; Grima,Pedro M.; Castellvi,Maria; Batalla,Consuelo; Font-Bardia,Merce
    参考文献:Tetrahedron 日期:2012 卷标:68(48) 页码:9982-9998]

    57535-94-1 = 930-27-8
    反应条件:1.1 Reagents: Sulfuric Acid
    标题:Short Synthesis Of 3-Methylfuran
    作者:Cornforth,J. W.
    参考文献:Journal Of The Chemical Society 日期:1958 卷标:1310]

    22037-28-1 = 930-27-8
    反应条件:1.1 Rt
    标题:Preparation Of 3-Aminomethyltetrahydrofuran With Furan As Raw Material
    参考文献:China]

    13423-15-9 = 930-27-8
    反应条件:1.1 Reagents: Ethanol,Hydrogen Catalysts: Alumina; 1250 H,1 Mpa,450 °C
    标题:Method For Producing Aromatic Hydrocarbon Via Aromatization
    参考文献:China]

    4412-96-8 = 930-27-8
    反应条件:1.1 Catalysts: Quinoline,Copper; 250 °C
    标题:Quinoline
    作者:Sherman,Angela R.
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2001]

    = 930-27-8
    反应条件:1.1 Reagents: Ethyl Nitrite,Nitric Oxide
    标题:Formation Of 3-Methylfuran From The Gas-Phase Reaction Of Oh Radicals With Isoprene And The Rate Constant For Its Reaction With The Oh Radical
    作者:Atkinson,Roger; Aschmann,Sara M.; Tuazon,Ernesto C.; Arey,Janet; Zielinska,Barbara
    参考文献:International Journal Of Chemical Kinetics 日期:1989 卷标:21(7) 页码:593-604]

    35392-66-6 = 930-27-8
    反应条件:1.1 Reagents: Chlorine
    标题:Products At The Reaction Of Amino Acids In Aqueous Solution With Chlorine
    作者:Ishikawa,Seiichi; Fujino,Hiroshi; Yasuda,Kazuhiko; Shigemori,Nobuyasu
    参考文献:Suishitsu Odaku Kenkyu (1978-1991) 日期:1986 卷标:9(12) 页码:786-92]

    = 930-27-8 [标题:Reaction Conditions
    标题:Preparation Of 3-Methylfuran
    参考文献:Japan
(Z)-2-Methylbut-2-Ene-1,4-Diol置于氧气,Palladium Diacetate,Copper (I) Acetate体系中,化学反应 15.0H,以77%的收率获得产物3-甲基呋喃
参考文献:Camus,Francis; Hasiak,Bruno; Martin,Marius,Synthetic Communications,1982,Vol. 12,# 8,P. 647-650
标题:Camus,Francis; Hasiak,Bruno; Martin,Marius,Synthetic Communications,1982,Vol. 12,# 8,P. 647-650

专利信息


专利号:US-2013338369-A1
优先权日:2011-03-07
标 题 :Process for the Synthesis of Aminobiphenylene
发明人:HEINRICH MARKUS; PRATSCH GERALD
权利人:HEINRICH MARKUS; PRATSCH GERALD; BASF SE
摘要:The present invention relates to a process for the synthesis of 2-aminobiphenylene and derivatives thereof by reacting a benzene diazonium salt with an aniline compound under basic reaction conditions.

专利号:US-10414903-B2
优先权日:2016-11-11
标题 :Methods for synthesis of end-functionalized polyolefins
发明人:GUIRONNET DAMIEN S; HYATT MICHAEL G; WALSH DYLAN J
权利人:UNIV ILLINOIS
摘要:A strategy for the synthesis of semi-telechelic polyethylene through the palladium diimine-catalyzed chain transfer polymerization of ethylene using various silanes as chain transfer agents is reported. Polymer molecular weight and end-group chemical structure can be tuned by varying the chain transfer agent as well as its concentration. NMR spectroscopy confirms that the silicon of the chain transfer agent is incorporated into the polymer. The stability of the catalyst toward polar monomer enables the chain transfer polymerization of semi-telechelic poly(ethylene-methyl acrylate) copolymers.

专利号:US-2004101523-A1
优先权日:1989-07-27
标题:Renal-selective prodrugs for control of renal smpathetic nerve activity in the treatment of hypertension
发明人:REITZ DAVID B; KOEPKE JOHN P; BLAINE EDWARD H; SCHUH JOSEPH R; MANNING ROBERT E; SMITS GLENN J
权利人:SEARLE & CO
摘要:Renal-selective prodrugs are described which are preferentially converted in the kidney to compounds capable of inhibiting synthesis of catecholamine-type neurotransmitters involved in renal sympathetic nerve activity. The prodrugs described herein are derived from inhibitor compounds capable of inhibiting one or more of the enzymes involved in catecholamine synthesis, such compounds being classifiable as tyrosine hydroxylase inhibitors, or as dopa-decarboxylase inhibitors, or as dopamine-β-hydroxylase inhibitors. These inhibitor compounds are linked to a chemical moiety, such as a glutamic acid derivative, by a cleavable bond which is recognized selectively by enzymes located predominantly in the kidney. The liberated inhibitor compound is then available in the kidney to inhibit one or more of the enzymes involved in catecholamine synthesis. Inhibition of renal catecholamine synthesis can suppress heightened renal nerve activity associated with sodium-retention related disorders such as hypertension. Conjugates of particular interest are glutamyl derivatives of dopamine-β-hydroxylase inhibitors, of which N-acetyl-γ-glutamyl fusaric acid hydrazide (shown below) is preferred.

专利号:WO-2024185775-A1
优先权日:2023-03-06
标 题:Long-chain alkenyloxy–substituted benzoyl derivative and oligonucleotide synthesis method using same
发明人:OKADA YOHEI; INANAGA KAZATO; SHOJI Yukiya; MIZUFUNE HIDEYA; SUDO TATSUYA; ADACHI Sota; HOSOI Kazushi
权利人:SPERA PHARMA INC; TOKYO UNIV OF AGRICULTURE AND TECHNOLOGY
摘要:The purpose of the present invention is to provide a novel pseudo–solid phase protecting group that can be used in liquid-phase oligonucleotide synthesis. The purpose of the present invention is also to provide an oligonucleotide synthesis method that uses a novel pseudo–solid phase protecting group. The present invention provides a compound represented by formula (1) (in which R represents a C14–60 alkenyl group, n represents 2 or 3, m represents 0 or 1, p represents 1 or 2, X represents C, N, O, or S, Y represents a single bond or B(CH 2 ) t * or may form a ring with X, and Z represents a single bond or (CH 2 ) s (s being an integer from 1 to 5)). The present invention also provides an oligonucleotide production method that uses the compound.

专利号:US-9388147-B2
优先权日:2009-11-13
标题 :Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
发明人:MARTINBOROUGH ESTHER; BOEHM MARCUS F; YEAGER ADAM RICHARD; TAMIYA JUNKO; HUANG LIMING; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TIMONY GREGG ALAN; BROOKS JENNIFER L; PEACH ROBERT; SCOTT FIONA LORRAINE; HANSON MICHAEL ALLEN
权利人:RECEPTOS INC; CELGENE INTERNAT II SÃ?RL
摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

专利号:US-6951878-B2
优先权日:1998-03-12
标 题:Benzo[b]thiophenyl or tetrahydro-benzo[b]thiophenyl modulators of protein tyrosine phosphatases (PTPases)
发明人:MOELLER NIELS PETER HUNDAHL; ANDERSEN HENRIK SUNE; IVERSEN LARS FOGH; OLSEN OLE HVILSTED; BRANNER SVEN; HOLSWORTH DANIEL DALE; BAKIR FARID; JUDGE LUKE MILBURN; AXE FRANK URBAN; JONES TODD KEVIN; RIPKA WILLIAM CHARLES; GE YU; UYEDA ROY TERUYUKI
权利人:NOVO NORDISK AS
摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. n The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.
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合成参考文献


摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 50.
摘要:Tius, M. A., Science of Synthesis Knowledge Updates, (2022) 1, 441.
摘要:Jiang, G.-J.; Wang, Y.; Yu, Z.-X., Science of Synthesis: Stereoselective Synthesis, (2011) 3, 49.
摘要:Jones, D. E.; Harmata, M., Science of Synthesis: Metal-Catalyzed Cyclization Reactions, (2016) 2, 334.
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