4090-48-6 = 930-27-8 反应条件:1.1 Reagents: Sulfuric Acid,Mercuric Sulfate 标题:Synthesis Of Furans From Acetylenic Epoxides And Diols 作者:Miller,David 参考文献:Journal Of The Chemical Society [section] C: Organic 日期:1969 卷标:(1) 页码:12-15]
82698-68-8 = 930-27-8 [标题:Reaction Conditions 标题:Photochemistry Of 3,6-Dihydro-1,2-Oxazines: A Versatile Route To Substituted Pyrroles 作者:Givens,R. S.; Choo,D. J.; Merchant,S. N.; Stitt,R. P.; Matuszewski,B. 参考文献:Tetrahedron Letters 日期:1982 卷标:23(13) 页码:1327-30]
955998-81-9 = 930-27-8 [标题:Reaction Conditions 标题:Product Class 9: Furans 作者:Koenig,B. 参考文献:Science Of Synthesis 日期:2002 卷标:9 页码:183-285]
534-22-5 = 930-27-8 [标题:Reaction Conditions 标题:Photoisomerization Of 2-Alkylfurans To 3-Alkylfurans 作者:Hiraoka,H.; Srinivasan,R. 参考文献:Journal Of The American Chemical Society 日期:1968 卷标:90(10) 页码:2720-1]
= 930-27-8 [标题:Reaction Conditions 标题:Carbohydrate Pyrolysis Mechanisms From Isotopic Labeling 作者:Paine,John B. Iii; Pithawalla,Yezdi B.; Naworal,John D. 参考文献:Journal Of Analytical And Applied Pyrolysis 日期:2008 卷标:83(1) 页码:37-63]
4412-96-8 = 930-27-8 反应条件:1.1 Reagents: Copper Solvents: Quinoline 标题:3-Methyl-2-Furoic Acid And 3-Methylfuran 作者:Burness,D. M. 参考文献:Organic Syntheses 日期:1959 卷标:39 页码:46-8]
4412-91-3 = 930-27-8 反应条件:1.1 Catalysts: P-Toluenesulfonic Acid,Titania,Palladium,Bis(Acetonitrile)Dichloro- (Supported On Tio2) Solvents: Methanol; 18 H 标题:Process For The Preparation Of Organic Compounds Via Reduction Of Allylic Compounds 参考文献:Japan]
= 930-27-8 反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Molybdenum,[[2,2′-[1,2-Ethanediylbis[(Nitrilo-Kn)Methylidyne]]Bis[phenolato-Ko]... Solvents: Benzene; 6 H,40 °C 标题:Process For Preparation Of 3-Methylfuran 参考文献:China]
498-60-2 = 930-27-8 [标题:Reaction Conditions 标题:Orientation In The Furan Nucleus. Vi. β-Substituted Furans 作者:Gilman,Henry; Burtner,Robert R. 参考文献:Journal Of The American Chemical Society 日期:1933 卷标:55 页码:2903-9]
4412-96-8 = 930-27-8 反应条件:1.1 Reagents: Quinoline Catalysts: Copper; 2.5 H,165 - 180 °C 标题:[4+3] Cycloaddition Of C-3 Substituted Furans. Stereoselectivity Induced By Coordination Effects 作者:Montana,Angel M.; Grima,Pedro M.; Castellvi,Maria; Batalla,Consuelo; Font-Bardia,Merce 参考文献:Tetrahedron 日期:2012 卷标:68(48) 页码:9982-9998]
57535-94-1 = 930-27-8 反应条件:1.1 Reagents: Sulfuric Acid 标题:Short Synthesis Of 3-Methylfuran 作者:Cornforth,J. W. 参考文献:Journal Of The Chemical Society 日期:1958 卷标:1310]
22037-28-1 = 930-27-8 反应条件:1.1 Rt 标题:Preparation Of 3-Aminomethyltetrahydrofuran With Furan As Raw Material 参考文献:China]
13423-15-9 = 930-27-8 反应条件:1.1 Reagents: Ethanol,Hydrogen Catalysts: Alumina; 1250 H,1 Mpa,450 °C 标题:Method For Producing Aromatic Hydrocarbon Via Aromatization 参考文献:China]
4412-96-8 = 930-27-8 反应条件:1.1 Catalysts: Quinoline,Copper; 250 °C 标题:Quinoline 作者:Sherman,Angela R. 参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2001]
= 930-27-8 反应条件:1.1 Reagents: Ethyl Nitrite,Nitric Oxide 标题:Formation Of 3-Methylfuran From The Gas-Phase Reaction Of Oh Radicals With Isoprene And The Rate Constant For Its Reaction With The Oh Radical 作者:Atkinson,Roger; Aschmann,Sara M.; Tuazon,Ernesto C.; Arey,Janet; Zielinska,Barbara 参考文献:International Journal Of Chemical Kinetics 日期:1989 卷标:21(7) 页码:593-604]
35392-66-6 = 930-27-8 反应条件:1.1 Reagents: Chlorine 标题:Products At The Reaction Of Amino Acids In Aqueous Solution With Chlorine 作者:Ishikawa,Seiichi; Fujino,Hiroshi; Yasuda,Kazuhiko; Shigemori,Nobuyasu 参考文献:Suishitsu Odaku Kenkyu (1978-1991) 日期:1986 卷标:9(12) 页码:786-92]
= 930-27-8 [标题:Reaction Conditions 标题:Preparation Of 3-Methylfuran 参考文献:Japan
专利号:US-2013338369-A1 优先权日:2011-03-07 标 题 :Process for the Synthesis of Aminobiphenylene 发明人:HEINRICH MARKUS; PRATSCH GERALD 权利人:HEINRICH MARKUS; PRATSCH GERALD; BASF SE 摘要:The present invention relates to a process for the synthesis of 2-aminobiphenylene and derivatives thereof by reacting a benzene diazonium salt with an aniline compound under basic reaction conditions.
专利号:US-10414903-B2 优先权日:2016-11-11 标题 :Methods for synthesis of end-functionalized polyolefins 发明人:GUIRONNET DAMIEN S; HYATT MICHAEL G; WALSH DYLAN J 权利人:UNIV ILLINOIS 摘要:A strategy for the synthesis of semi-telechelic polyethylene through the palladium diimine-catalyzed chain transfer polymerization of ethylene using various silanes as chain transfer agents is reported. Polymer molecular weight and end-group chemical structure can be tuned by varying the chain transfer agent as well as its concentration. NMR spectroscopy confirms that the silicon of the chain transfer agent is incorporated into the polymer. The stability of the catalyst toward polar monomer enables the chain transfer polymerization of semi-telechelic poly(ethylene-methyl acrylate) copolymers.
专利号:US-2004101523-A1 优先权日:1989-07-27 标题:Renal-selective prodrugs for control of renal smpathetic nerve activity in the treatment of hypertension 发明人:REITZ DAVID B; KOEPKE JOHN P; BLAINE EDWARD H; SCHUH JOSEPH R; MANNING ROBERT E; SMITS GLENN J 权利人:SEARLE & CO 摘要:Renal-selective prodrugs are described which are preferentially converted in the kidney to compounds capable of inhibiting synthesis of catecholamine-type neurotransmitters involved in renal sympathetic nerve activity. The prodrugs described herein are derived from inhibitor compounds capable of inhibiting one or more of the enzymes involved in catecholamine synthesis, such compounds being classifiable as tyrosine hydroxylase inhibitors, or as dopa-decarboxylase inhibitors, or as dopamine-β-hydroxylase inhibitors. These inhibitor compounds are linked to a chemical moiety, such as a glutamic acid derivative, by a cleavable bond which is recognized selectively by enzymes located predominantly in the kidney. The liberated inhibitor compound is then available in the kidney to inhibit one or more of the enzymes involved in catecholamine synthesis. Inhibition of renal catecholamine synthesis can suppress heightened renal nerve activity associated with sodium-retention related disorders such as hypertension. Conjugates of particular interest are glutamyl derivatives of dopamine-β-hydroxylase inhibitors, of which N-acetyl-γ-glutamyl fusaric acid hydrazide (shown below) is preferred.
专利号:WO-2024185775-A1 优先权日:2023-03-06 标 题:Long-chain alkenyloxy–substituted benzoyl derivative and oligonucleotide synthesis method using same 发明人:OKADA YOHEI; INANAGA KAZATO; SHOJI Yukiya; MIZUFUNE HIDEYA; SUDO TATSUYA; ADACHI Sota; HOSOI Kazushi 权利人:SPERA PHARMA INC; TOKYO UNIV OF AGRICULTURE AND TECHNOLOGY 摘要:The purpose of the present invention is to provide a novel pseudo–solid phase protecting group that can be used in liquid-phase oligonucleotide synthesis. The purpose of the present invention is also to provide an oligonucleotide synthesis method that uses a novel pseudo–solid phase protecting group. The present invention provides a compound represented by formula (1) (in which R represents a C14–60 alkenyl group, n represents 2 or 3, m represents 0 or 1, p represents 1 or 2, X represents C, N, O, or S, Y represents a single bond or B(CH 2 ) t * or may form a ring with X, and Z represents a single bond or (CH 2 ) s (s being an integer from 1 to 5)). The present invention also provides an oligonucleotide production method that uses the compound.
专利号:US-9388147-B2 优先权日:2009-11-13 标题 :Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis 发明人:MARTINBOROUGH ESTHER; BOEHM MARCUS F; YEAGER ADAM RICHARD; TAMIYA JUNKO; HUANG LIMING; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TIMONY GREGG ALAN; BROOKS JENNIFER L; PEACH ROBERT; SCOTT FIONA LORRAINE; HANSON MICHAEL ALLEN 权利人:RECEPTOS INC; CELGENE INTERNAT II SÃ?RL 摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.
专利号:US-6951878-B2 优先权日:1998-03-12 标 题:Benzo[b]thiophenyl or tetrahydro-benzo[b]thiophenyl modulators of protein tyrosine phosphatases (PTPases) 发明人:MOELLER NIELS PETER HUNDAHL; ANDERSEN HENRIK SUNE; IVERSEN LARS FOGH; OLSEN OLE HVILSTED; BRANNER SVEN; HOLSWORTH DANIEL DALE; BAKIR FARID; JUDGE LUKE MILBURN; AXE FRANK URBAN; JONES TODD KEVIN; RIPKA WILLIAM CHARLES; GE YU; UYEDA ROY TERUYUKI 权利人:NOVO NORDISK AS 摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. n The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 50. 摘要:Tius, M. A., Science of Synthesis Knowledge Updates, (2022) 1, 441. 摘要:Jiang, G.-J.; Wang, Y.; Yu, Z.-X., Science of Synthesis: Stereoselective Synthesis, (2011) 3, 49. 摘要:Jones, D. E.; Harmata, M., Science of Synthesis: Metal-Catalyzed Cyclization Reactions, (2016) 2, 334.