CAS: 90891-21-7; H-Hophe-Oet.Hcl

该化合物是氨基酸苯丙氨的衍生物,其特点是存在乙基酯组和盐酸盐形式,该化合物一般是白色的脱白晶粉,可溶于水和极地有机溶剂,在各种生物化学应用中提高其效用;主要用于浸泡合成,并作为研制药品和生物活性化合物的构件;乙基酯组的存在使得与自由酸形式相比,生物利用率和稳定性得到改善;作为盐酸盐,该化合物在水溶液中表现出更高的溶性与稳定性,使之适合于各种实验室和工业用途;此外,L-Homotybyaline 乙基氯化物可作为非对称合成的助产物,有助于生产对等纯化合物;在处理安全数据之前,应审查这些数据,与所有化学物质一样,以确保采取适当的防范措施.

结构式图片

相似化合物

90940-54-8 1012-05-1 82795-51-5

物理性质

MSDS等安全信息

欧盟法规

C&L通报

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CAS号64-17-5 乙醇 | CAS号943-73-7 L-高苯丙氨酸 | CAS号115276-75-0 ethyl 2-(4-meth... | CAS号536-74-3 苯乙炔 | CAS号46460-23-5 (S)-2-氨基-4-苯基丁酸乙酯 | CAS号16503-46-1 2-溴-4-苯基丁酸 | CAS号1012-05-1 DL-高苯丙氨酸 | CAS号5440-40-4 Benzenebutanoic... | CAS号82717-96-2 N-[1-(S)-乙氧羰基-3... | CAS号89396-94-1 盐酸咪达普利

合成工艺路线路线简述

  • 合成目标产物 L-Homophenylalanine Ethyl Ester Hydrochloride 主要起始原料 Ethyl (R)-2-Hydroxy-4-Phenylbutyrate
  • 630102-87-3 = 90891-21-7
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol; 17 H,1.1 Bar,Rt
    标题:Ethyl 2,4-Dioxo-4-Phenylbutyrate: A Versatile Intermediate For The Large-Scale Preparation Of Enantiomerically Pure α-Hydroxy And α-Amino Acid Esters
    作者:Blaser,Hans-Ulrich; Burkhardt,Stephan; Kirner,Hans Juerg; Moessner,Tanja; Studer,Martin
    参考文献:Synthesis 日期:2003 卷标:(11) 页码:1679-1682]

    = 90891-21-7
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethyl Acetate1.2 Reagents: Ceric Ammonium Nitrate Solvents: Acetonitrile,Water1.3 Reagents: Hydrochloric Acid
    标题:Asymmetric Transfer Hydrogenation Of β,γ-Alkynyl α-Imino Esters By A Bronsted Acid
    作者:Kang,Qiang; Zhao,Zhuo-An; You,Shu-Li
    参考文献:Organic Letters 日期:2008 卷标:10(10) 页码:2031-2034]

    943-73-7 = 90891-21-7
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Ethanol
    标题:Alkynylation Of Mixed Acetals With Organotin Acetylides
    作者:Zhai,Dongguan; Zhai,Weixu; Williams,Robert M.
    参考文献:Journal Of The American Chemical Society 日期:1988 卷标:110(8) 页码:2501-5]

    943-73-7 = 90891-21-7
    反应条件:1.1 Reagents: Hydrochloric Acid
    标题:Synthesis And Pharmacology Of The Potent Angiotensin-Converting Enzyme Inhibitor N-[1(S)-(Ethoxycarbonyl)-3-Phenylpropyl]-(S)-Alanyl-(S)-Pyroglutamic Acid
    作者:Johnson,Alexander L.; Price,William A.; Wong,Pancras C.; Vavala,Robert F.; Stump,John M.
    参考文献:Journal Of Medicinal Chemistry 日期:1985 卷标:28(11) 页码:1596-602]

    202003-05-2 = 90891-21-7
    反应条件:1.1 Reagents: Zinc,Ammonium Chloride Solvents: Ethanol,Water; 10 Min,Reflux
    标题:Reduction Of Azides To Amines Or Amides With Zinc And Ammonium Chloride As Reducing Agent
    作者:Lin,Wenqing; Zhang,Xiaomei; He,Ze; Jin,Yi; Gong,Liuzhu; Et Al
    参考文献:Synthetic Communications 日期:2002 卷标:32(21) 页码:3279-3284]

    202003-05-2 = 90891-21-7
    反应条件:1.1 Reagents: 1,3-Diphenyldisiloxane Catalysts: Triphenylphosphine Solvents: Cyclopentyl Methyl Ether; 24 H,22 °C1.2 Reagents: Water; 22 °C1.3 Reagents: Hydrochloric Acid Solvents: 1,4-Dioxane; 22 °C
    标题:Catalytic Staudinger Reduction At Room Temperature
    作者:Lenstra,Danny C.; Wolf,Joris J.; Mecinovic,Jasmin
    参考文献:Journal Of Organic Chemistry 日期:2019 卷标:84(10) 页码:6536-6545]

    202003-05-2 = 90891-21-7
    反应条件:1.1 Reagents: Poly(Methylhydrosiloxane) Catalysts: Triphenylphosphine Solvents: Cyclopentyl Methyl Ether; 20 H,110 °C1.2 Reagents: Water; 15 Min,110 °C; 110 °C -> Rt1.3 Reagents: Hydrochloric Acid Solvents: Diethyl Ether,1,4-Dioxane; Rt
    标题:Sustainable Organophosphorus-Catalysed Staudinger Reduction
    作者:Lenstra,Danny C.; Lenting,Peter E.; Mecinovic,Jasmin
    参考文献:Green Chemistry 日期:2018 卷标:20(19) 页码:4418-4422]

    = 90891-21-7
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethyl Acetate1.2 Reagents: Ceric Ammonium Nitrate Solvents: Acetonitrile,Water1.3 Reagents: Hydrochloric Acid Solvents: Water
    标题:Unprecedented Effects Of Additives And Ligand-To-Metal Ratio On The Enantiofacial Selection Of Copper-Catalyzed Alkynylation Of α-Imino Ester With Arylacetylenes
    作者:Shao,Zhihui; Wang,Jun; Ding,Kai; Chan,Albert S. C.
    参考文献:Advanced Synthesis & Catalysis 日期:2007 卷标:349 页码:2375-2379]

    943-73-7 = 90891-21-7
    反应条件:1.1 Reagents: Thionyl Chloride Solvents: Ethanol
    标题:Studies On Angiotensin Converting Enzyme Inhibitors. 4. Synthesis And Angiotensin Converting Enzyme Inhibitory Activities Of 3-Acyl-1-Alkyl-2-Oxoimidazolidine-4-Carboxylic Acid Derivatives
    作者:Hayashi,Kimiaki; Nunami,Kenichi; Kato,Jyoji; Yoneda,Naoto; Kubo,Masami; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:1989 卷标:32(2) 页码:289-97
📜(S)-2-氨基-4-苯基丁酸乙酯置于盐酸体系中,用 水 作为反应溶剂,化学反应生成 (S)-(+)-2-氨基-4-苯基丁酸乙酯 盐酸盐
参考文献:Asymmetric Transfer Hydrogenation Of β,γ-Alkynyl α-Imino Esters By A Brønsted Acid
标题:Asymmetric Transfer Hydrogenation Of β,γ-Alkynyl α-Imino Esters By A Brønsted Acid
摘要:Asymmetric Synthesis Of Trans-Alkenyl Alpha-Amino Esters Was Realized By Chiral Phosphoric Acid Catalyzed Transfer Hydrogenation Of Beta,Gamma-Alkynyl Alpha-Imino Esters. Utilizing Hantzsch Esters As The Hydrogen Donor,Both The Alkyne And Imine Moieties Of Beta,Gamma-Alkynyl Alpha-Imino Esters Were Reduced To Afford Trans-Alkenyl Alpha-Amino Esters With Up To 96% Ee.
DOI:10.1021/ol800494R

海关参考信息

专利信息


专利号:US-8338565-B2
优先权日:2008-08-20
标 题 :Macrocyclic compounds for inhibition of tumor necrosis factor alpha
发明人：LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P
权利人:LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P; ENSEMBLE THERAPEUTICS CORP
摘要:Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.

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合成参考文献

合成方法参考DOI号:10.1021/jm00149a009
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