CAS: 88738-78-7; Methyl 2-(Bis(2,2,2-Trifluoroethoxy)Phosphoryl)Acetate

相似化合物

124755-24-4 1067-74-9 867-13-0

上下游产品

2,2,2-trifluoroethanol (methoxycarbonylmethyl)phosphonic dichloride methyl 2-(bis((trimethylsilyl)oxy)phosphoryl)acetate phosphonoacetic acid trimethyl ester(R,S)-(Z)-3-(2-Tetrahydrofuryl)propenoic acid methyl ester methyl (Z)-3-(4-trifluoromethylphenyl)acrylate (2Z)-decenoic acid methyl ester methyl (E)-dec-2-enoate

📜2,2,2-三氟乙醇,Methyl 2-(Bis((Trimethylsilyl)Oxy)Phosphoryl)Acetate置于碘,三苯基膦,咪唑体系中,用 氯仿 作为反应溶剂,化学反应 6.0H,以11.2 G的收率获得产物o,O'-双(2,2,2-三氟乙基)磷乙酸甲酯
参考文献:钯/异硫脲协同催化乙烯基环丙烷和 α,β-不饱和酯的对映选择性缩甲醛 (3+2) 环加成反应
标题:钯/异硫脲协同催化乙烯基环丙烷和 α,β-不饱和酯的对映选择性缩甲醛 (3+2) 环加成反应
摘要:钯和异硫脲协同催化允许乙烯基环丙烷和 α,β-不饱和酯进行形式 (3+2) 环加成,通过 α,β-不饱和酰基铵中间体反应生成官能化环戊烷,并添加 Licl,这对于获得高产物非对映和对映选择性.
DOI:10.1002/anie.202202621

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-7968736-B2
优先权日:2002-09-06
标 题:Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof
发明人：CURRAN DENNIS P; SHIN YOUSEUNG; CHOY NAKYEN; DAY BILLY W; BALACHANDRAN RAGHAVAN; MADIRAJU CHARITHA; TURNER TIFFANY
权利人:UNIV PITTSBURGH & MDASH OF THE COMMONWELTH SYSTEMS OF HIGHER EDUCATION
摘要:A compound of the following structure: n n n n n n n n n n wherein R 1 is H, an alkyl group, an aryl group, an alkenyl group, an alkynyl group, or a halogen atom; n R 2 is H, an alkyl group, an aryl group, a benzyl group, a trityl group, —SiR a R b R c , CH 2 OR d , or COR e ; n R a , R b and R c are independently an alkyl group or an aryl group; n R d is an alkyl group, an aryl group, an alkoxylalkyl group, —R i SiR a R b R c or a benzyl group, wherein R i is an alkylene group; n R e is an alkyl group, an allyl group, a benzyl group, an aryl group, an alkoxy group, or —NR g R h , wherein R g and R h are independently H, an alkyl group or an aryl group; n R 3 is (CH 2 ) n where n is and integer in the range of 0 to 5, —CH 2 CH(CH 3 )—, —CHâ• CH—, —CHâ• C(CH 3 )—, or —C≡C—; n R 4 n n n n n n n n n n n n  wherein y1 and y2 are 1 and y3, y4 and y5 are independently 0 or 1, R k1 , R k2 , R k3 , R k4 and R k5 are independently H, CH 3 , or OR 2a , and R s1 , R s2 , R s3 , and R s4 are independently H or CH 3 , wherein R 2a is H, an alkyl group, an aryl group, a benzyl group, a trityl group, —SiR a R b R c , CH 2 OR d , or COR e ; and n R 5 is H or OR 2b , wherein R 2b is H, an alkyl group, an aryl group, an aryl group,a benzyl group, a trityl group, —SiR a R b R c , CH 2 OR d , or COR e .

专利号:US-11465997-B2
优先权日:2017-06-22
标 题 :Synthesis of disorazoles and analogs thereof as potent anticancer agents
发明人：NICOLAOU KYRIACOS C; BELLAVANCE GABRIEL; BUCHMAN MAREK; PULUKURI KIRAN KUMAR; RIGOL STEPHAN
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present disclosure provides disorazole analogs of the formula: Formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.

专利号:US-9994558-B2
优先权日:2013-09-20
标题 :Multicyclic compounds and methods of using same
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).

专利号:US-2023128195-A1
优先权日:2017-07-06
标 题:Synthesis of halichondrins

专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.