CAS: 82419-36-1; 9-Fluoro-3-Methyl-10-(4-Methylpiperazin-1-yl)-7-Oxo-3,7-Dihydro-2H-[1,4]Oxazino[2,3,4-Ij]Quinoline-6-Carboxylic Acid

上下游产品

CAS号109-01-3 N-甲基哌嗪 | CAS号82419-35-0 氟嗪羧酸 | CAS号119-91-5 2,2'-联喹啉 | CAS号6148-64-7 丙二酸单乙酯钾盐 | CAS号94695-48-4 2,3,4,5-四氟苯甲酰氯 | CAS号86760-99-8 diethyl [(-)-7,... | CAS号115551-33-2 6-氨基-2,3-二氟苯酚 | CAS号85741-74-8 diethyl N-(3,4-... | CAS号144298-04-4 N-(3,4-二氟苯基)氨基甲酸叔丁酯 | CAS号124409-86-5 diethyl [3,4-di... | CAS号93107-30-3 1-环丙基-6,7-二氟-1,... | CAS号100986-85-4 左氧氟沙星 | CAS号100986-86-5 R-9-氟-2,3-二氢-3-...

6-氨基-2,3-二氟苯酚置于硫酸,Lithium Perchlorate,乙酸酐,Sodium Hydride,三苯基膦,偶氮二甲酸二乙酯体系中,用 乙醇,二甲基亚砜,乙酸乙酯 作为反应溶剂,化学反应 41.75H,反应生成 氧氟沙星
参考文献:Adrio,Javier; Carretero,Juan C.; Garcia Ruano,Jose L.,Heterocycles,1999,Vol. 51,# 7,P. 1563-1572
标题:Adrio,Javier; Carretero,Juan C.; Garcia Ruano,Jose L.,Heterocycles,1999,Vol. 51,# 7,P. 1563-1572

专利信息

专利号:US-5521310-A
优先权日:1992-10-07
标 题 :Process to obtain benzoxazines to be used for the synthesis of ofloxazine, levofloxazine and derivatives
发明人：CARRETERO GONZALVEZ JUAN-CARLO; VICIOSO SANCHEZ MERCEDES; GARCIA RUANO JOSE-LUIS
权利人:ETILO DERIVADOS
摘要:A process to obtain benzoxazines useful for the synthesis of Ofloxazine, Levofloxazine and derivatives. The benzoxacines (I) where Xb is an halogen and R 1 is H, alkyl or alkenyl of up to 6 atoms of C or aryl, can be obtained by means of cycling a compound of formula (II) through the reaction with triphenylphosphine and ethyl azodicarboxilate. The compounds of formula (II) can be obtained through the reaction of a compound (III) with an adequate epoxide. Through the use of the adequate chiral epoxide it is possible to obtain the enantiomerically desired intermediate and, therefore and selectively, it is possible to obtain the desired final product with the adequate enantiomeric form without the need to carry out a resolution stage. n The Compounds (I) are useful and key intermediates for the synthesis of the antimicrobials Oflixazine and Levofloxazine. ##STR1##

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-2024197774-A1
优先权日:2021-04-16
标 题:Synthesis of Antimicrobial PVP-coated Bismuth Nanoparticles
发明人：LOPEZ-RIBOT JOSE; VAZQUEZ-MUNOZ ROBERTO
权利人:UNIV TEXAS
摘要:Described herein is a facile, fast, and economical method for the synthesis of BAL-mediated PVP-BiNPs, using basic laboratory instruments and reagents readily available in most laboratories.

专利号:US-2011087037-A1
优先权日:2007-10-31
标题:Synthesis of ring b abeo-sterols as novel inhibitors of mycobacterium tuberculosis
发明人：RODRIGUEZ-PIERLUISSI ABIMAEL D; WEI XIAOMEI
权利人:INTELLECTUAL PROPERTY AND TECHNOLOGY VIC OFF OF
摘要:Novel 3β-hydroxy-Δ 5 -steroid analogs possessing a contracted cyclopentane B-ring provide good inhibitory activity against Mycobacterium tuberculosis . The 5(6→7)abeo-sterol nucleus present in compounds of the invention represents a novel scaffold for the development of new antitubercular agents.

专利号:US-10308663-B2
优先权日:2015-06-16
标题:Inhibitors of PTP4A3 for the treatment of cancer
发明人：LAZO JOHN S; SHARLOW ELIZABETH R; MCQUEENEY KELLEY E; WIPF PETER; SALAMOUN JOSEPH M
权利人:LAZO JOHN S; SHARLOW ELIZABETH R; MCQUEENEY KELLEY E; WIPF PETER; SALAMOUN JOSEPH M; UNIV VIRGINIA PATENT FOUNDATION; UNIV OF PITTSBURGH —OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
摘要:The invention provides protein tyrosine phosphatase inhibitor compounds, Their pharmaceutical compositions, uses, and methods of use, such as in the treatment of various cancers, and process for making the compounds. Also disclosed is an improved synthesis of protein tyrosine phosphatase inhibitor and precursor compound thienopyridone (5).

专利号:US-9982005-B2
优先权日:2013-04-04
标 题 :Macrolides and methods of their preparation and use
发明人：MYERS ANDREW G; SEIPLE IAN BASS; ZHANG ZIYANG
权利人:HARVARD COLLEGE
摘要:Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.