CAS: 74562-03-1; (R)-2-((Tert-Butoxycarbonyl)Amino)-2-(Thiophen-2-yl)Acetic Acid
该化合物是氨基酸衍生物,其特征为硫苯环和三氧碳酸基保护组.该组物质在异乙酸动物体内有一个手性中心,表明该物质存在于一种特定的立体异构体形式中.Boc组作为氨基功能的保护组,在需要选择性除保的情况下,在丙酸合成和其他有机反应中有用.硫苯环有助于该化合物的芳香特性,并可能影响其溶性与再活性.一般而言,这种性质的化合物因其潜在的生物活动和与各种生物目标互动的能力,对医药化学和药物开发具有兴趣.存在水医学(致癌酸)和水利恐惧(硫苯和Boc)成分表明该分子可能表现出有趣的药理学特性.
- 英文名称(R)-2-((Tert-Butoxycarbonyl)Amino)-2-(Thiophen-2-yl)Acetic Acid
- 中文名称Boc-(R)-2-(2-噻吩基)-甘氨酸
- IUPAC名称(R)-2-((tert-butoxycarbonyl)amino)-2-(thiophen-2-yl)acetic acid
- 其它别名Boc-(R)-2-Thienylglycine, ; (R)-2-((Tert-Butoxycarbonyl)Amino)-2-(Thiophen-2-yl)Acetic Acid; (2R)-2-[(2-Methylpropan-2-yl)Oxycarbonylamino]-2-Thiophen-2-Ylacetic Acid
- CAS编号74562-03-1
- MFCD编号:MFCD02682478
- 分子式:C11H15NO4S分子量:257.31
- 产品CID: 1735710
- 产品分类有机原料→生命科学→氨基酸及其衍生物→甘氨酸及其衍生物
相似化合物
43189-45-3 208259-66-9 28044-76-0物理性质
MSDS等安全信息
上下游产品
D,L-(2-thienyl)glycine tert-butyl dicarbonatedi-tert-butyl dicarbonate thiophene-2-carbaldehyde tert-butyl carbazateter-t-butyl 2-{[3-(cyclohexylcarbonyl)pyridin-2-yl]amino}-2-oxo-1-thien-2-ylethylcarbamate tert-buty 2-{[3-(4-fluorobenzoyl)pyridin-2-yl] amino}-2-oxo-1-thien-2-ylethylcarbamate 24H24N2O4SC24H24N2O4S (3R)-3-(2-(tert-butoxycarbonylamino)-2-(thiophen-2-yl)acetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]°Ctane chloride合成工艺路线路线简述
- 合成目标产物 Boc-(R)-2-Thienylglycine 主要起始原料 2-Thiopheneethanethioic Acid, α-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-, S-Ethyl Ester
- (文献来源)合成步骤主要原料 2-Thiopheneethanethioic Acid, α-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-, S-Ethyl Ester
📜S-Ethyl 2-[(2-Methylpropan-2-yl)Oxycarbonylamino]-2-Thiophen-2-Ylethanethioate置于三辛胺,水体系中,用 Various Solvent(S) 作为反应溶剂,化学反应 5.0H,以95%的收率获得产物boc-(R)-2-(2-噻吩基)-甘氨酸
参考文献:氨基酸硫酯的化学酶动力学动力学拆分
标题:氨基酸硫酯的化学酶动力学动力学拆分
摘要:发现外消旋-N-保护的β,γ-不饱和α-氨基酸硫代酯的l-形式是枯草杆菌蛋白酶催化水解成相应酸的底物.d-对映体在有机碱的存在下连续消旋.在双相系统中的合并的反应允许基于动态动力学拆分使氨基酸衍生物脱氨.获得了优异的产率和对映选择性.
DOI:10.1002/adsc.200700050
海关参考信息
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2905143000-叔丁醇
2912110000-甲醛
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专利信息
专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
专利号:WO-9967219-A1
优先权日:1998-06-22
标 题:Compounds for inhibiting beta-amyloid peptide release and/or its synthesis
发明人：AUDIA JAMES E; PORTER WARREN J; THOMPSON RICHARD C; WILKIE STEPHEN C; STACK DOUGLAS R; SHI QING
权利人:ELAN PHARM INC; LILLY CO ELI; AUDIA JAMES E; PORTER WARREN J; THOMPSON RICHARD C; WILKIE STEPHEN C; STACK DOUGLAS R; SHI QING
摘要:Compounds of formula (I), wherein W is a cyclic group of the type (2); (3); Y is represented by the formula (II); these compounds inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
专利号:WO-9966934-A1
优先权日:1998-06-22
标 题 :CYCLIC AMINO ACID COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS
发明人：AUDIA JAMES E; DRESSMAN BRUCE A; SHI QING
权利人:ELAN PHARM INC; LILLY CO ELI; AUDIA JAMES E; DRESSMAN BRUCE A; SHI QING
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
专利号:US-6774125-B2
优先权日:1998-06-22
标 题:Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; THOMPSON RICHARD C; WILKIE STEPHEN C; BRITTON THOMAS C; PORTER WARREN J; HUFFMAN GEORGE W; LATIMER LEE H
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
专利号:US-6509331-B1
优先权日:1998-06-22
标题:Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; THOMPSON RICHARD C; WILKIE STEPHEN C; BRITTON THOMAS C; PORTER WARREN J; HUFFMAN GEORGE W; LATIMER LEE H
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
专利号:US-6849650-B2
优先权日:1998-02-27
标 题:Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THORSETT EUGENE D; PORTER WARREN J; NISSEN JEFFREY S; LATIMER LEE H; AUDIA JAMES E; DROSTE JAMES
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
