专利号:EP-1119635-B1 优先权日:1998-10-09 标 题 :Non-homogeneous systems for the resolution of enantiomeric mixtures 发明人:YAO YIMING; WANG YI FONG; ALMOND MERRICK R 权利人:ALTHEA TECHNOLOGIES INC; GILEAD SCIENCES INC 摘要:The present invention relates to a process for the biocatalyst-mediated enantioselective conversion of enantiomeric mixtures of hydrophobic esters using a biphasic solvent system. More particularly, the present invention relates to the enzyme-mediated enantioselective synthesis of anti-viral compounds, such as 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane (FTC) and its analogues, in a non-homogeneous reaction system.
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