CAS: 63-99-0; 1-(M-Tolyl)Urea

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CAS号626-36-8 脲基甲酸乙酯 | CAS号108-44-1 3-甲基苯胺 | CAS号590-28-3 氰酸钾 | CAS号638-03-9 间甲苯胺盐酸盐 | CAS号57-13-6 尿素 | CAS号917-61-3 氰酸钠 | CAS号55591-33-8 N-(m-tolyl)cyanamide | CAS号85754-39-8 N-nitroso-N-m-t... | CAS号621-40-9 间甲基苯基硫脲 | CAS号620-50-8 1,3-bis(3-methy... | CAS号621-29-4 间甲苯异氰酸酯 | CAS号2028-72-0 m-toluenediazon... | CAS号85754-39-8 N-nitroso-N-m-t... | CAS号5544-33-2 1-(2-chloroacet... | CAS号620-50-8 1,3-bis(3-methy...

M-Tolylcyanamide置于oscl2(η6-P-Cymene)(Pme2Oh),水体系中,化学反应 1.0H,以72%的收率获得产物间甲苯脲
参考文献:亚膦酸基钌(II)和(II)配合物催化水合氰胺:范围和机理的见解
标题:亚膦酸基钌(II)和(II)配合物催化水合氰胺:范围和机理的见解
摘要:通过使用水合相应的氰胺r 1 R 2 Nc N成功地完成了多种脲r 1 R 2 Nc(o)nh 2的合成(r 1和r 2 =烷基,芳基或h; 26个实例)的三价膦酸基配合物[的mc1 2(η 6-P-Cymene)(pme 2 Oh)](m =茹(1),锇(2))作为催化剂.反应在温和的条件下(40-70oc)干净进行,没有任何添加剂,使用低金属负载量(1 Mol%)和水作为唯一溶剂.在几乎所有情况下,Complex配合物2的反应活性都比钌配合物1高.另外,对于两种催化剂,氰酰胺底物水合所观测到的反应速率明显快于涉及传统脂族和芳族腈的反应速率.计算研究使我们能够合理化所有这些趋势.因此,计算表明存在直接与碳原子相连的氮原子当与金属中心配位时,N键通过感应效应使腈碳电子减少,从而促进次膦酸配体的oh基团对该碳的分子内亲核攻击.另一方面,Os对ru的较高反应性似乎与初始金属环上较低的环应
DOI:10.1039/d0Cy00523A

专利信息

专利号:US-8013153-B2
优先权日:2006-03-23
标 题:Substituted pyrimidine kinase inhibitors
发明人：BUTLER JEANNENE; CONNOLLY PETER J; FUENTES-PESQUERA ANGEL R; GREENBERGER LEE M; HUANG SHENLIN; LAMONTAGNE JR KENNETH R; LI RONGHUA; XU GUOZHANG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to substituted pyrimidine compounds of formula (I): n nand forms thereof, their synthesis and use for treating a chronic or acute protein kinase mediated disease, disorder or condition.

专利号:CN-107235917-A
优先权日:2016-12-31
标题 :A class of licochalcone A dihydropyrimidine compounds with antitumor activity and its synthesis method

专利号:RU-2139282-C1
优先权日:1992-02-27
标 题:Derivatives of benzodiazepine, method of their synthesis, pharmaceutical composition