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CAS号608-07-1 5-甲氧基色胺 | CAS号4350-09-8 5-羟基色氨酸 | CAS号111-76-2 乙二醇丁醚 | CAS号20776-45-8 5-苄氧基色胺 | CAS号77549-09-8 5-hydroxy-Nb-me... | CAS号1215-59-4 5-苄氧基吲哚 | CAS号1453-97-0 5-苄氧基芦竹碱 | CAS号5933-28-8 5-苄氧基吲哚-3-乙酰胺 | CAS号53157-46-3 2-[2-(5-hydroxy... | CAS号53157-50-9 BENZYL[2-(5-HYD... | CAS号108535-01-9 3-(2-aminoethyl... | CAS号108560-71-0 3-(2-Aminoethyl... | CAS号18186-43-1 血清素β-D-葡糖苷酸 | CAS号1892-21-3 2-(5-hydroxy-1H... | CAS号3000-36-0 1H-Pyrido[3,4-b... | CAS号374680-35-0 3,4,5,6-tetrahy... | CAS号20776-45-8 5-苄氧基色胺 | CAS号53157-50-9 BENZYL[2-(5-HYD... | CAS号1210-83-9 N-乙酰-5-羟基色胺 | CAS号16310-20-6 3-(2-氨基乙基)-1H-吲...

合成工艺路线路线简述

    褪黑素 反应生成 5-羟基色胺
    参考文献:S-Adenosyl Methionine Regulation Of Metabolic Pathways And Its Use In
    标题:S-Adenosyl Methionine Regulation Of Metabolic Pathways And Its Use In
    摘要:一种新的疾病范式围绕着s-腺苷甲硫氨酸(sam)的代谢途径,这些途径的中间产物以及受sam途径影响的其他代谢途径.提供了分析和调节与疾病或状况相关的sam途径的方法.这些方法允许识别和利用用于这些疾病状态和状况的诊断和治疗方案以及药物.

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    专利信息


    专利号:US-2025101045-A1
    优先权日:2022-01-18
    标题:Synthesis of boron-containing amidoxime reagents and their application to synthesize functionalized oxadiazole and quinazolinone derivatives
    发明人:DAS BHASKAR
    权利人:LONG ISLAND UNIV
    摘要:The present disclosure is concerned with borylated amidoximes useful in the synthesis of biologically relevant drug-like molecules, including functionalized oxadizole and quinazolinone derivatives. Also disclosed are methods of making borylated amidoximes, methods of making functionalized oxadiazole and quinazolinone compounds using the amidoximes, and functionalized oxadiazole and quinazolinone compounds prepared from borylated amidoximes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

    专利号:US-2006030625-A1
    优先权日:2004-08-06
    标 题 :Dietary neurotransmitter precursors for balanced synthesis of neurotransmitters
    发明人:HART CHERYLE RAM; GROSSMAN RONALD S; RAM HERBERT
    权利人:HART CHERYLE RAM; GROSSMAN RONALD S; RAM HERBERT
    摘要:Dietary supplements for treating a neurotransmitter deficiency include one or more precursors of the deficient neurotransmitter and a cofactor for activating in vivo enzymatic synthesis of the deficient neurotransmitter. The dietary supplements can also include an appropriate neurotransmitter, such as an amino acid. When administered through the oral mucosa, increases in levels of the deficient neurotransmitters and relief from deficiency symptoms are obtained.

    专利号:WO-9614060-A1
    优先权日:1994-11-04
    标题 :Use of receptor agonists to stimulate superoxide dismutase activity
    发明人:MARKLUND STEFAN L; STRAALIN PONTUS
    权利人:MARKLUND STEFAN L; STRAALIN PONTUS
    摘要:The present invention relates to the use of a substance for the manufacture of a composition for stimulating the release of EC-SOD from cells or stimulating the synthesis of EC-SOD in cells. In particular, the invention relates to the use of a substance for the manufacture of a composition for prophylaxis or treatment of a disease or disorder connected with the presence or formation of superoxide radicals and other toxic intermediates derived from the superoxide radical. Further, the invention relates to a method for determining the effect of a substance with respect to stimulating the release of EC-SOD from cells or stimulating the synthesis of EC-SOD in cells and to substances which have been selected by said method. Within the scope of the invention is a method of preventing, diminishing, controlling or inhibiting a disease or disorder connected with the presence or formation of superoxide radicals and other toxic intermediates derived from the superoxide radical in a patient who has been established to have a high risk of developing a such disease or disorder, or who has developed a such disease or disorder, the method comprising administering an effective amount of a substance which is capable of stimulating the release of EC-SOD from cells or stimulating the synthesis of EC-SOD in cells.

    专利号:US-11628186-B2
    优先权日:2017-02-24
    标题 :Method and composition for the reduction of viral replication, duration and spread of the COVID-19 and the flu
    发明人:MARTIN ALAIN
    权利人:MARTIN ALAIN; CELLULAR SCIENCES INC
    摘要:A method for stimulating the synthesis of nasal nitric oxide and nasal and lung surfactants to inhibit the docking and adhesion of viruses to cellular receptors, including ACE2, to reduce viral replication, duration, spread and severity of infections, and also to inhibit lung fibrosis, increase the synthesis of serotonin to reduce coughing and mouth breathing, reduce the cytokine storm produced by LI-6 caused by viruses such as COVID-19 and flu in patients susceptible to these infections, including patients with hypoxemia, asthma, chronic obstructive pulmonary disease, cystic fibrosis, diabetics, interstitial lung disease, pulmonary fibrosis, allergic rhinitis, sinusitis, smokers, sleep apnea and lung cancer, which includes: contacting mammalian cells with a therapeutically effective amount of a composition, said composition including the following constituents: sodium pyruvate; a phosphate; a salt of calcium; and a salt of magnesium.

    专利号:US-8455619-B2
    优先权日:2008-11-25
    标 题 :Polypeptide synthesis for drug delivery
    发明人:LATHAM KEITH R
    权利人:LATHAM KEITH R
    摘要:The present invention provides improved methods for the synthesis of polypeptide or peptide-linked compounds via a NCA-based polymerization reaction that produces high product yields in much less time. Such improved methods are achieved by application of a higher temperature and/or reduced pressure to the reaction such that an NCA-containing monomer melts.

    专利号:US-12006301-B1
    优先权日:2021-05-13
    标题 :And synthesis of dual 5-HT1A and 5-HT7 receptor ligands
    发明人:ABLORDEPPEY SETH Y
    权利人:FLORIDA A&M UNIV
    摘要:Novel dual 5-HT1A and 5-HT7 receptor ligands and methods of using the novel ligands to treat a neurological disorder are presented.
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    合成参考文献


    参考文献:10.1177/0960327110362702
    摘要:Fakhfouri G, Rahimian R, Daneshmand A, Bahremand A, Rasouli MR, Dehpour AR, Mehr SE, Mousavizadeh K. Granisetron ameliorates acetic acid-induced colitis in rats. Hum Exp Toxicol. 2010 Apr;29(4):321–8. doi: 10.1177/0960327110362702.
    参考文献:10.1159/000089915
    摘要:Munafò MR, Clark TG, Roberts KH, Johnstone EC. Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression. Neuropsychobiology. 2006;53(1):1–8. doi: 10.1159/000089915.
    参考文献:10.1007/s00228-010-0784-7
    摘要:Chopade AR, Mulla WA. Novel strategies for the treatment of inflammatory hyperalgesia. European Journal of Clinical Pharmacology. 2010 Feb 13;66(5):429–44. doi: 10.1007/s00228-010-0784-7.
    参考文献:10.1159/000089916
    摘要:Serretti A, Mandelli L, Lorenzi C, Landoni S, Calati R, Insacco C, Cloninger CR. Temperament and character in mood disorders: influence of DRD4, SERTPR, TPH and MAO-A polymorphisms. Neuropsychobiology. 2006;53(1):9–16. doi: 10.1159/000089916.
    参考文献:10.1007/s10072-010-0218-4
    摘要:Fröhlich I, Pilloy W, Vaillant M, Diederich NJ. Myocardial MIBG scintigraphy: a useful clinical tool : A retrospective study in 50 parkinsonian patients. Neurol Sci. 2010 Jun;31(3):403–6. doi: 10.1007/s10072-010-0218-4.
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