CAS: 458-05-9; 1-(3-Fluorophenyl)-2-Thiourea

该化合物是一种有机化合物,其特征是存在硫尿素功能组,由碳原子双层覆盖硫磺和单层覆盖矿物质组组成.该化合物具有氟联苯组,特别是3-氟联苯混合物,可影响其化学反应和生物活动.该化合物在室内温度上一般是固体,在极地有机溶剂中可溶解.氟素原子的存在可增强该化合物的脂性,并可能影响其与生物目标的相互作用.1-3-氟联苯-2-硫尿素对医药化学和农业应用很感兴趣,经常研究其作为除草剂或药物开发的潜力.该化合物的再活动可归因于硫尿组,该组可参与各种化学反应,包括核糖基替代和凝聚反应.应当参考安全数据,以便处理,因为许多具有对环境影响的毒性和潜在衍生物具有毒性.

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CAS号372-19-0 3-氟苯胺 | CAS号82635-62-9 1-BENZOYL-3-(3-... | CAS号404-72-8 异硫氰酸3-氟苯酯 | CAS号224791-45-1 2-[(2-amino-4-f... | CAS号20358-07-0 2-氨基-5-氟苯并噻唑 | CAS号20358-08-1 2-氨基-7-氟苯并噻唑 | CAS号872726-44-8 GW 610

合成工艺路线路线简述

    📜异硫氰酸(3-氟苯)酯置于ammonium Hydroxide体系中,用 水,乙腈 作为反应溶剂,化学反应 3.0H,以100%的收率获得产物1-(3-氟苯基)-2-硫脲
    参考文献:一锅式形成高度功能化的5-溴-2-氨基噻唑,潜在的内源性大麻素水解酶magl抑制剂
    标题:一锅式形成高度功能化的5-溴-2-氨基噻唑,潜在的内源性大麻素水解酶magl抑制剂
    摘要:带有各种取代基的高度官能化的5-溴-2-氨基-1,3-噻唑可以通过快速有效的一锅法轻松制备,使用简单的起始原料和温和的条件,同时避免使用金属催化剂或不方便的试剂,例如作为元素卤素.这些有用的产物可以用作其他反应的起始原料或用作药理学上有意义的化合物.在我们的工作中,我们证明了所产生的5-溴噻唑化合物可能导致μm范围内的单酰基甘油脂酶(magl)抑制.
    DOI:10.1016/j.Tetlet.2018.10.055

    专利信息


    专利号:US-2008004415-A1
    优先权日:2004-05-03
    标题 :Non-linear optically active molecules, their synthesis, and use
    发明人：MCGINNISS VINCENT D; RISSER STEVEN M; DROTLEFF ELIZABETH; JIANG EDWARD; SPAHR KEVIN B
    权利人:OPTIMER PHOTONICS INC
    摘要:In one aspect, the present invention provides a hyperpolarizable organic chromophore. The chromophore is a nonlinear optically active compound that includes a Ï€-donor conjugated to a Ï€-acceptor through a Ï€-electron conjugated bridge. In other aspects of the invention, donor structures and acceptor structures are provided. In another aspect of the invention, a chromophore-containing polymer is provided. In one embodiment, the chromophore is physically incorporated into the polymer to provide a composite. In another embodiment, the chromophore is covalently bonded to the polymer, either as a side chain polymer or through crosslinking into the polymer. In other aspects, the present invention also provides a method for making the chromophore, a method for making the chromophore-containing polymer, and methods for using the chromophore and chromophore-containing polymer.

    专利号:US-2012059163-A1
    优先权日:2005-04-28
    标题 :Non-linear opticaly active molecules, their synthesis, and use
    发明人：MCGINNISS VINCENT D; RISSER STEVEN M; DROTLEFF ELIZABETH; JIANG EDWARD; SPAHR KEVIN B
    权利人:MCGINNISS VINCENT D; RISSER STEVEN M; DROTLEFF ELIZABETH; JIANG EDWARD; SPAHR KEVIN B; OPTIMER PHOTONICS INC
    摘要:In one aspect, the present invention provides a hyperpolarizable organic chromophore. The chromophore is a nonlinear optically active compound that includes a Ï€-donor conjugated to a Ï€-acceptor through a Ï€-electron conjugated bridge. In other aspects of the invention, donor structures and acceptor structures are provided. In another aspect of the invention, a chromophore-containing polymer is provided. In one embodiment, the chromophore is physically incorporated into the polymer to provide a composite. In another embodiment, the chromophore is covalently bonded to the polymer, either as a side chain polymer or through crosslinking into the polymer. In other aspects, the present invention also provides a method for making the chromophore, a method for making the chromophore-containing polymer, and methods for using the chromophore and chromophore-containing polymer.

    专利号:CN-106674128-A
    优先权日:2016-12-31
    标题 :A class of licochalcone A thiouracil derivatives with anti-tumor activity and its synthesis method

    专利号:CN-107235916-A
    优先权日:2016-12-31
    标题:A kind of licochalcone A thiouracil derivative with antitumor activity and its synthesis method

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    主要参考文献

    参考标题:Small Molecule Library Synthesis Using Segmented Flow
    作者:Christina M. Thompson,Jennifer L. Poole,Jeffrey L. Cross,Irini Akritopoulou-Zanze,Stevan W. Djuric
    摘要:Flow Chemistry Has Gained Considerable Recognition As A Simple, Efficient, And Safe Technology For The Synthesis Of Many Types Of Organic And Inorganic Molecules Ranging In Scope From Large Complex Natural Products To Silicon Nanoparticles. In This Paper We Describe A Method That Adapts Flow Chemistry To The Synthesis Of Libraries Of Compounds Using A Fluorous Immiscible Solvent As A Spacer Between Reactions. The Methodology Was Validated In The Synthesis Of Two Small Heterocycle Containing Libraries. The Reactions Were Performed On A 0.2 Mmol Scale, Enabling Tens Of Milligrams Of Material To Be Generated In A Single 200 Ml Reaction Plug. The Methodology Allowed Library Synthesis In Half The Time Of Conventional Microwave Synthesis While Maintaining Similar Yields. The Ability To Perform Multiple, Potentially Unrelated Reactions In A Single Run Is Ideal For Making Small Quantities Of Many Different Compounds Quickly And Efficiently.

    合成参考文献


    参考文献:10.1016/j.bbrc.2023.08.050
    摘要:Ikeda Y, Davis MI, Sumita K, Zheng Y, Kofuji S, Sasaki M, Hirota Y, Pragani R, Shen M, Boxer MB, Takeuchi K, Senda T, Simeonov A, Sasaki AT. Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells. Biochemical and Biophysical Research Communications. 2023 Oct;679():116–21. doi: 10.1016/j.bbrc.2023.08.050.
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