CAS: 2053-29-4; Methyleneamine

Aminomethyl置于paraquat Dichloride体系中,化学反应生成亚甲基亚胺
参考文献:Glycine Decarboxylation: The Free Radical Mechanism
标题:Glycine Decarboxylation: The Free Radical Mechanism
摘要:Radiation Chemical Methods Were Used To Investigate The Reactions Of Glycine Anions,H2Nch2Co2-(Gly(-)),With (Oh)-O-.,(Ch3)(2)(Coh)-O-.,And (Ch3)-C-. Radicals. A Major And Most Significant Product From All Of These Processes Is Co2. Pulse-Radiolysis Revealed That The Initial Step In The (Oh)-O-.-Induced Mechanism Is Oxidation Of The Amino Group,Producing (+h2N.)-Ch2-Co2-And Hn.-Ch2-Co2-With Yields Of 63% And 37%,Respectively. The Amino Radical Cation,(+h2N.)-Ch2-Co2-,Suffers Fast (Less Than Or Equal To 100 Ns) Fragmentation Into Co2 + (Ch2Nh2)-C-.. The Other Primary Radical,Hn.-Ch2-Co2-,Can Also Be Converted Into The Decarboxylating (+h2N.)-Ch2-Co2-By Reaction With Proton Donors Such As Phosphate (H2Po4-/k = 7.4 X 10(7) M-1 S(-1),And Hpo42-/k = 2.5 X 10(5) M-1 S(-1)) Or The Glycine Zwitterion,Gly(+/-) (K = 3.9 X 10(5) M-1 S(-1)),But Only On A Much Longer (Typically Mu S To Ms) Time Scale (K Approximate To 4 X 10(5) M-1 S(-1)). Competitively,The Hn.-Ch2-Co2-Transforms Into A Carbon-Centered Radical H2N-(Ch)-H-.-Co2-Either By An Intramolecular 1,2-H-Atom Shift (K = (1.2 +/-1.0) X 10(3) S(-1)) Or By Bimolecular Reaction With Gly(-) (K = (3.0 +/-0.2) X 10(4) M-1 S(-1)). Both C-Centered Radicals,H2N-(Ch)-H-.-Co2-And (Ch2Nh2)-C-.,Are Reductants As Verified Through Their Reactions With Fe(Cn)(6)(3-) And Methyl Viologen (Mv2+) In Pulse-Radiolysis Experiments (K Approximate To 4 X 10(9) M-1 S(-1)). The Eventual Complete Transformation Of All Primary Radicals Into H2N-(Ch)-H-.-Co2-And (Ch2Nh2)-C-. Was Further Substantiated By Gamma-Radiolytic Reduction Of Fe(Cn)(6)(3-). In The Presence Of Suitable Electron Donors,The Hn.-Ch2-Co2-Radical Acts As An Oxidant. This Was Demonstrated Through Its Reaction With Hydroquinone (K = (7.4 +/-0.5) X 10(7) M-1 S(-1)).Although The C-Centered H2N-(Ch)-H-.-Co2-Radical Is Not Generated In A Direct H-Atom Abstraction By (Oh)-O-.,This Radical Appears To Be The Exclusive Product In The Reaction Of Gly(-) With (Ch3)(2)(Coh)-O-.,(Ch2Nh2)-C-.,And (Ch3)-C-. (K Approximate To 10(2) M-1 S(-1)). A Most Significant Finding Is That H2N-(Ch)-H-.-Co2-Can Be Converted Into The Decarboxylating N-Centered Radical Cation (+h2N.)-Ch2-Co2-By Reaction With Proton Donors Such As Gly(+/-) (K Approximate To 3 X 10(3) M-1 S(-1)) Or Phosphate And Thus Also Becomes A Source Of Co2. The (Ch2Nh2)-C-.-Induced Route Establishes,In Fact,A Chain Mechanism Which Could Be Proven Through Dose Rate Effect Experiments And Suppression Of The Chain Upon Addition Of Fe(Cn)(6)(3-) Or Mv2+ As A Scavenger For The Reducing Precursor Radicals. The Possible Initiation Of Amino Acid Decarboxylation By C-Centered Radicals And The Assistance Of Proton Donors At Various Stages Within The Overall Mechanism Are Considered To Be Of General Significance And Interest In Chemical And Biological Systems.
Doi:10.1021/ja9815428

专利信息

专利号:US-2004152905-A1
优先权日:2003-01-31
标题:Universal building blocks and support media for synthesis of oligonucleotides and their analogs
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and chemically modified oligonucleotide analogs, are provided. In addition, methods for functionalization of a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-2004242897-A1
优先权日:2002-07-31
标题 :Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-10751419-B2
优先权日:2014-05-01
标题:Method for synthesis of reactive conjugate clusters
发明人：MIGAWA MICHAEL T; YU JINGHUA; WAN W BRAD; PATEL SAYTEN P; VASQUEZ GUILLERMO; KINBERGER GARTH A; PRAKASH THAZHA P; SETH PUNIT P; SWAYZE ERIC E
权利人:IONIS PHARMACEUTICALS INC
摘要:Provided herein are improved methods for the synthesis of reactive conjugate clusters and intermediates used in such methods. In particular, improvements are provided that enhance the synthesis of reactive conjugate clusters by reducing the number of synthetic steps required. The reactive conjugate clusters prepared using the improved methods don't include any transacylation impurities that are formed using existing methods. The improved methods also provide an increase in overall yield and a cost benefit over existing methods.

专利号:US-9126995-B2
优先权日:2011-11-08
标题:Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound
发明人：TOYAMA KEN-ICHI; MORIYAMA YUJI; MATOBA KAZUTAKA; YAOSAKA MANABU; IKEDA EITATSU
权利人:NISSAN CHEMICAL IND LTD
摘要:There is provided a method for catalytic asymmetric synthesis of optically active isoxazoline compound and an optically active isoxazoline compound. A method for catalytic asymmetric synthesis of optically active isoxazoline compound of a formula (6) including reacting an α,β-unsaturated carbonyl compound of a formula (1) and a hydroxylamine in a solvent in the presence of a base by adding a chiral phase transfer catalyst. An optically active isoxazoline compound of a formula (13) that can be synthesized by the method.

专利号:US-2005130201-A1
优先权日:2003-10-14
标 题 :Splint-assisted enzymatic synthesis of polyribounucleotides
发明人：DERAS MICHAEL; PLEISS JEFFREY A; SCARINGE STEPHEN
权利人:DHARMACON INC
摘要:The present invention comprises methods and compositions for splint-assisted enzymatic synthesis of polyribonucleotides using an RNA polymerizing enzyme. The invention provides ligating ribonucleotides comprising ligating a donor RNA molecule to an acceptor RNA molecule in the presence of RNA ligase and a splint, wherein the donor RNA molecule is comprised of at least one nucleotide and a ligation linker moiety, the acceptor RNA molecule is comprised of at least one nucleotide and a ligation linker moiety and the splint is comprised of a polyribonucleotide. The invention also provides splints for use in splint-assisted enzymatic synthesis using an RNA polymerizing enzyme.

专利号:US-2012203004-A1
优先权日:2009-08-13
标题 :process for the synthesis of alkyl/aralkyl (2s)-2-(tert-butoxycarbonyl)-amino-2-[-8-azabicyclo[3.2.1]oct-3-yl]-exo-acetate and analogs thereof: key intermediates for the preparation of dppiv inhibitors
发明人：ROY BHAIRAB NATH; KAMBOJ RAJENDER KUMAR; GOERGE SHAJI K; VENUGOPAL SPINVIN C; SHANMUGVADIVELU MUTHU KUMARAN; SINHA NEELIMA
权利人:ROY BHAIRAB NATH; KAMBOJ RAJENDER KUMAR; GOERGE SHAJI K; VENUGOPAL SPINVIN C; SHANMUGVADIVELU MUTHU KUMARAN; SINHA NEELIMA; LUPIN LTD
摘要:An improved process for the synthesis of intermediates like Alkyl/Aralkyl (2S)-2-(tert-butoxycarbonyl)-amino-2-[-8-azabicyclo[3.2.1]oct-3-yl]-exo-acetate and analogs thereof which are useful in the synthesis of Dipeptidyl peptidase-IV (DP-PIV) inhibitors.