专利号:US-7619116-B2 优先权日:2003-12-17 标 题:Intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts and process for their preparation 发明人:DAMBRIN VALERY; LENOIR JEAN-YVES; SCHNEIDER JEAN-MARIE; GUILLAMOT GERARD; FOLLET MICHEL; BECKER ABRAM 权利人:PRODUCTS CHIMIQUES AUXILIAIRES 摘要:A subject matter of the present invention is novel intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts, and also the associated preparation process.
专利号:US-6018042-A 优先权日:1994-08-09 标题:Antitumor antisense oligonucleotides 发明人:METT HELMUT; HAENER ROBERT; DEAN NICHOLAS MARK 权利人:NOVARTIS AG 摘要:The invention relates to deoxyribo- and ribo-oligonucleotides and derivatives thereof, as well as pharmaceutical preparations, therapies, diagnostics and commercial research reagents in relation to disease states which respond to modulation of the synthesis of the enzyme S-adenosylmethionine decarboxylase (SAMDC). In particular, the invention relates to antisense oligonucleotides and oligonucleotide derivatives specifically hybridizable with nucleic acids relating to (preferably human) SAMDC. These oligonucleotides and their derivatives have been found to modulate the synthesis of SAMDC in cells.
专利号:US-5639867-A 优先权日:1993-09-17 标 题 :TTTr as protective group in nucleotide synthesis 发明人:BRILL WOLFGANG K-D 权利人:CIBA GEIGY CORP 摘要:The invention relates to nucleosides, nucleotides and oligonucleotides carrying in their basic structure a primary hydroxyl group protected by tris-4,4',4'-tert-butylphenylmethyl, to processes for the preparation of said nucleosides and nucleotides, to a process for the preparation of oligonucleotides, and to the use of said protected nucleosides, nucleotides and oligonucleotides.
专利号:WO-9800434-A1 优先权日:1996-06-28 标 题:Modified oligonucleotides 发明人:DE MESMAEKER ALAIN; WENDEBORN SEBASTIAN; LEBRETON JACQUES 权利人:CIBA GEIGY AG; MESMAEKER ALAIN DE; WENDEBORN SEBASTIAN; LEBRETON JACQUES 摘要:It is one object of the present invention to provide an oligonucleotide of formula (1): 5'-(U)n-3' in which U is an identical or different radical of a natural or a synthetic nucleoside, wherein the oligonucleotide comprises at least one modified nucleotide dimer comprising two nucleoside analogs connected via an amide-bond that has a certain configuration; the synthesis of these compounds and their use in pharmaceutical preparations.
专利号:WO-9738114-A1 优先权日:1996-04-09 标题 :Puromycin-sensitive aminopeptidases 发明人:FONTANA ADRIANO; CONSTAM DANIEL BEAT; TOBLER ANDREAS RUDOLF; ALTMANN KARL-HEINZ; SCHLAPBACH RALPH 权利人:CIBA GEIGY AG; FONTANA ADRIANO; CONSTAM DANIEL BEAT; TOBLER ANDREAS RUDOLF; ALTMANN KARL HEINZ; SCHLAPBACH RALPH 摘要:The present invention relates to puromycin-sensitive aminopeptidases, antibodies generated against said aminopeptidases, and to means and methods for the production thereof. The invention is also directed to nucleic acids coding for said aminopeptidases, and fragments thereof, to methods of obtaining such nucleic acid molecules or fragments of the invention, and to systems suitable for the expression of such nucleic acids. One particular aspect of this invention relates to deoxyribo- and ribo-oligonucleotides and derivatives thereof, as well as pharmaceutical preparations, therapies, diagnostics and commercial research reagents in relation to disease states which respond to modulation of the synthesis of the enzyme puromycin-sensitive aminopeptidase (PSA).
专利号:US-2007106079-A1 优先权日:2003-12-17 标题:Novel intermediates for the synthesis of (r)-tamsulosin and of its pharmaceutically acceptable salts and process for their preparation
参考标题:Oxidative Umpolung Selenocyanation Of Ketones And Arenes: An Efficient Protocol To The Synthesis Of Selenocyanates 作者:Jianguo Cui,Meizhen Wei,Liping Pang,Junan Xiao,Chunfang Gan,Jiali Guo,Chuanfang Xie,Qiming Zhu,Yanmin Huang |发布日期:2020.3 摘要:A Practical Method For The Umpolung Selenocyanation Of Aryl Ketones, Alkyl Ketones, β-Ketoesters And Electron-Rich Arenes Has Been Developed, Affording Various Selenocyanates In Moderate To Excellent Yields. This Transformation Proceeds By An Oxidative Umpolung Selenocyanation Through Nitrogen Oxides-Mediated Electrophilic Selenocyanation Process. This Method Is Simpler, More Efficient, And Less Costly
合成参考文献
摘要:Balaban, T. S.; Balaban, A. T., Science of Synthesis, (2003) 14, 145.