CAS: 200936-87-4; Boc-Leu-Oh•h2O

专利信息

专利号:WO-2024151344-A9
优先权日:2022-11-18
标题:A device that enables the combinatorial synthesis of small molecule libraries
发明人：COPELAND Gregory; LIU JANE
权利人:BRT BIOTECHNOLOGIES INC
摘要:A device for the synthesis of small molecules on a substrate is provided. The device includes a synthesis plate with vias, and a microfluidic patterning plate with a series ot open-faced channels that can be aligned with the vias on the synthesis plate. The device may be used to synthesize combinatorial libraries of small molecules.

专利号:EP-1246837-B1
优先权日:2000-01-11
标 题:Oligomers of nonpeptide restricted mimetics of dipeptides or tripeptides and the use thereof in the synthesis of synthetic proteins and polypeptides
发明人：AMBLARD MURIEL; MARTINEZ JEAN; BERGE GILBERT
权利人:CENTRE NAT RECH SCIENT
摘要:The invention relates to nonpeptide oligomers of amino acids. The oligomers comprise -(NR'-A-CO)-O- units which represent a nonpeptide, restricted-mimetic inducer of the beta turn in a dipeptide or tripeptide fragment. Said oligomers may be produced by peptide synthesis techniques, whether in solution or in the solid phase, and can be used in the synthesis of synthetic proteins or polypeptides, in which the peptide fragment(s) (is) are identical to those of the corresponding natural protein or polypeptide and whose structural fragment(s) comprise(s) a fragment of an oligomer according to the invention.

专利号:US-4242256-A
优先权日:1977-03-15
标 题 :Synthesis of peptide analogues
发明人：SHARPE ROBERT; SZELKE MICHAEL
权利人:SHARPE ROBERT; SZELKE MICHAEL
摘要:Compounds being analogues of a dipeptide in which the nitrogen atom of the linking amide group of the dipeptide is replaced by trivalent group ##STR1## and in which, optionally, the carbonyl function of this linking group is replaced by the divalent group --CH 2 -- are of value in the synthesis of isosterically modified peptides.

专利号:US-11708341-B2
优先权日:2016-08-05
标题:Synthesis of (S)-2-amino-4-methyl-((R)-2-methyloxirane-2-yl)-pentan-1-one and pharmaceutically acceptable salts thereof
发明人：Beaver Matthew; CUI SHENG; SHI XIANGQING
权利人:AMGEN INC
摘要:The present invention provides new methods for preparing compound 5, and pharmaceutically acceptable salts thereof, of structure n nCompound 5, or a pharmaceutically acceptable salt thereof, is an important intermediate in the synthesis of carfilzomib. The invention further provides methods of making a useful manganese catalyst that may be used in the epoxidation step of the present invention.

专利号:US-4105652-A
优先权日:1977-08-05
标 题 :Synthesis of human β-endorphin
发明人：MEIENHOFER JOHANNES ARNOLD; WANG SU-SUN
权利人:HOFFMANN LA ROCHE
摘要:Human β-endorphin (β h -endorphin) is prepared by solution phase peptide synthesis. Synthesis proceeded via the protected β-endorphin fragments 1-9, 10-18, 19-21 and 22-31.

专利号:US-8217142-B2
优先权日:1996-07-17
标题 :Liquid phase peptide synthesis of KL-4 pulmonary surfactant
发明人：ABDEL-MAGID AHMED F; EGGMANN URS; MARYANOFF CYNTHIA ANNE; THALER ADRIAN; VILLANI FRANK J
权利人:ABDEL-MAGID AHMED F; EGGMANN URS; MARYANOFF CYNTHIA ANNE; THALER ADRIAN; VILLANI FRANK J; ORTHO PHARMA CORP
摘要:The invention relates to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu 4 ) 4 -Lys, of the pulmonary surfactant KL-4. These process are amenable to large scale synthesis and one process employs a method of saponifying an ester which reduces the inherent racemization of the α-carbon.