CAS: 1828-66-6; Morpholine-4-Sulfonyl Chloride

相似化合物

63698-84-0 1156821-26-9 2171201-91-3

上下游产品

CAS号110-91-8 吗啉 | CAS号108085-16-1 morpholine-4-so... | CAS号7791-25-5 磺酰氯 | CAS号10024-89-2 吗啡啉盐酸盐 | CAS号23328-69-0 n-氯吗啉 | CAS号15159-40-7 4-吗啉碳酰氯

📜吗啉置于磺酰氯,三乙胺体系中,用 乙腈 用作溶剂,化学反应 0.5H,反应生成4-吗啉磺酰氯
参考文献:三组分磺酰胺合成中的s(vi):使用氯化硫作为钯催化的suzuki-Miyaura偶联中的关键
标题:三组分磺酰胺合成中的s(vi):使用氯化硫作为钯催化的suzuki-Miyaura偶联中的关键
摘要:在钯催化的三组分磺酰胺合成中,氯化硫被用作-So 2-基团的来源.原位生成的氨磺酰氯与硼酸之间的suzuki-Miyaura偶联以中等至高收率产生了多种磺酰胺,并具有出色的反应选择性.尽管此转化不适用于伯胺或苯胺,但结果表明官能团耐受性高.通过解决脱磺酰化问题并利用廉价且容易获得的氯化硫作为二氧化硫的来源,首先实现了氧化还原中性三组分合成的磺酰胺.
Doi:10.1039/d1Sc01351C

专利信息

专利号:US-6252082-B1
优先权日:1997-01-16
标 题 :Pyridone derivatives, their preparation and their use as synthesis intermediates
发明人：LASSALLE GILBERT; BELLEVERGUE PATRICE; BOURBIER JEAN-CLAUDE; GALTIER DANIEL; MARTIN VALERIE
权利人:SANOFI SYNTHELABO
摘要:The invention concerns compounds of formula (I)in which: R is -NO2 or -NHR3, R3 being hydrogen, -COR4 (R4 selected among (C1-C4) alkyl, aryl and aryl (C1-C4) alkyl, -COOR5 (R5 selected among (C1-C4) alkyl and aryl (C1-C4) alkyl), -CONHR6 or SO2R6 (R6 selected among (C1-C5) alkyl, aryl and aryl(C1-C4) alkyl), -SO2NR7R8 (R7 and R8 independently of each other represent hydrogen or (C1-C4) alkyl or form with the nitrogen atom a morpholine group), aryl (C1-C4) alkyl, R1 is a (C1-C4) alkyl group linear or branched, cyclo (C3-C8) alkyl, aryl optionally substituted, aryl (C1-C4) alkyl optionally substituted, heteroaryl, R2 is a hydrogen atom, a (C1-C4) alkyl or arylmethyl group, X is an oxygen or sulphur atom, a -CH2-, -SO2 or -NR1- group and Y is a hydrogen atom or (C1-C6) alkyl. The invention is applicable to synthesis intermediates.

专利号:WO-2010115869-A1
优先权日:2009-04-03
标 题 :Propofol phosphonyl derivatives, synthesis, and use in long acting formulations
发明人：GONNISSEN YVES RENE JOHANNA PAUL
权利人:SEPS PHARMA N V; GONNISSEN YVES RENE JOHANNA PAUL
摘要:This invention relates to compounds represented by the structural formula (I), and the salts and stereoisomers thereof, wherein: - L is a linker selected from the group consisting of -(CH 2 ) P -O-, a single bond, formula (IA), -(CH 2 ) 1-8 -O-X(O)-, and - p is an integer from 1 to 8, - each R 3 and each R 4 is independently selected from the group consisting of C 1-20 alkyl, C 3-12 alkyl, C 3-12 cycloalkyl-C 1-4 alkyl, saturated heterocyclyl and saturated heterocyclyl-C 1-4 alkyl, and - X and Y are each independently C or S(O), - Z is selected from the group consisting of O, S(O) and NR 5 , - W is selected from the group consisting of halogen, OH, S(O)H and O - M + wherein M + is a monovalent cation; and - R 5 is selected from the group consisting of hydrogen and C 1-10 alkyl. These compounds are useful pharmaceutical agents with improved oral bioavailability.

专利号:RU-2067585-C1
优先权日:1991-09-12
标 题 :Derivatives of 5-amino-4-hydroxyhexanoic acid and a method of their synthesis