CAS: 182498-32-4; 1-(2-Bromophenyl)-3-(2-Hydroxy-4-Nitrophenyl)Urea

该化合物是一种有机化合物,其特性是尿素功能组,与两个不同的芳香环相连;一个苯环上存在溴原子,另一个环上存在氢氧基组,以及另一个环上存在硝基组,有助于其化学反应和潜在的生物活动;该化合物一般在室温下是固体的,根据具体情况,在有机溶剂中可能出现中等溶解性;氢氧基和硝基亚基亚基苯可影响其极性和氢联结能力,使其在各种化学和制药应用中具有兴趣;此外,该化合物可能由于芳香系统的存在而具有特定的光特性,这些特性可能与材料科学和药用化学等领域有关;在处理和储存时,应参考安全数据,因为溴和硝基化合物的存在可能构成某种危险.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

2-bromophenyl is°Cyanate 5-Nitro-2-aminophenol

合成工艺路线路线简述

    📜异氰酸2-溴苯酯,2-氨基-5-硝基苯酚置于1-(2-溴苯基)-3-(2-羟基-4-硝基苯基)脲,二氯甲烷,Hexanes体系中,用afforded The Title Compound(530 Mg,47%)的收率获得1-(2-溴苯基)-3-(2-羟基-4-硝基苯基)脲
    参考文献:Il-8 Receptor Antagonists
    标题:Il-8 Receptor Antagonists
    摘要:本发明涉及新型化合物和苯基脲在治疗由趋化因子interleukin-8(il-8)介导的疾病状态中的新用途.

    海关参考信息

    专利信息


    专利号:US-9333264-B2
    优先权日:2013-03-06
    标 题:Biocompatible polymeric nanoparticles degrade and release cargo in response to biologically relevant levels of hydrogen peroxide
    发明人：ALMUTAIRI ADAH; DE GRACIA LUX CAROLINE
    权利人:UNIV CALIFORNIA
    摘要:Disclosed are compositions and synthesis methods that pertain to biocompatible polymeric capsules capable of undergoing backbone degradation and cargo release upon exposure to biologically relevant concentrations of hydrogen peroxide (50-100 μM of H 2 O 2 ). In the invention, bio-responsive polyester bearing boronic ester triggers groups that degrade upon exposure to low concentrations of H 2 O 2 . The degradation is induced by transformation of a boronic ester to a phenol, which undergoes a quinone methide rearrangement to break down the polyester backbone.

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Bergeron P, Dos Santos M, Sitterle L, Tarlet G, Lavigne J, Liu W, Gerbé de Thoré M, Clémenson C, Meziani L, Schott C, Mazzaschi G, Berthelot K, Benadjaoud MA, Milliat F, Deutsch E, Mondini M. Non-homogenous intratumor ionizing radiation doses synergize with PD1 and CXCR2 blockade. Nat Commun. 2024 Oct 14;15(1):8845. doi: 10.1038/s41467-024-53015-9.
    2: Zhao J, Jian C, Chen Z, Cai J, Zhou C, Li M, Yang Y, Gao Y. Inhibition of CXCR2 as a therapeutic target for chronic post-surgical pain: Insights from animal and cell models. Cytojournal. 2024 Aug 29;21:28. doi: 10.25259/Cytojournal_46_2024.
    3: Yang YS, Liu CY, Pei MQ, Sun ZD, Lin S, He HF. Quercetin protects against sepsis-associated encephalopathy by inhibiting microglia-neuron crosstalk via the CXCL2/CXCR2 signaling pathway. Phytomedicine. 2024 Nov;134:155987. doi: 10.1016/j.phymed.2024.155987. Epub 2024 Aug 26. 11(38):e2400370. doi: 10.1002/advs.202400370. Epub 2024 Aug 7.

    合成参考文献


    参考文献:10.1016/j.expneurol.2014.05.014
    摘要:Cao D, Zhang Z, Xie R, Jiang B, Ji R, Gao Y. Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2. Experimental Neurology. 2014 Nov;261():328–36. doi: 10.1016/j.expneurol.2014.05.014.
    参考文献:10.1111/jcmm.13070
    摘要:Pu Y, Wang M, Hong Y, Wu Y, Tang Z. Adiponectin promotes human jaw bone marrow mesenchymal stem cell chemotaxis via CXCL1 and CXCL8. J Cellular Molecular Medi. 2017 Feb 08;21(7):1411–9. doi: 10.1111/jcmm.13070.
    参考文献:10.1038/s41416-020-1026-0
    摘要:Yang M, Zhang G, Wang Y, He M, Xu Q, Lu J, Liu H, Xu C. Tumour-associated neutrophils orchestrate intratumoural IL-8-driven immune evasion through Jagged2 activation in ovarian cancer. British Journal of Cancer. 2020 Aug 11;123(9):1404–16. doi: 10.1038/s41416-020-1026-0.
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