专利号:WO-2017175101-A1 优先权日:2016-04-07 标 题:Synthesis of copper phthalocyanine using deep eutectic solvent 发明人:SHANKARLING G S; JOGLEKAR AMRUTA R 权利人:SHANKARLING G S 摘要:The present disclosure generally relates to synthesis of copper phthalocyanine. In particular, the present disclosure relates to a method of synthesis of copper phthalocyanine using deep eutectic solvent (DES), which can be carried out at low temperature, does not involve use of high boiling solvents, uses less urea and allows solvents used in the process to be recycled.
专利号:US-5939304-A 优先权日:1997-06-05 标题:Method for synthesis of anhydrothrombin 发明人:SUZUKI TOYOAKI; HOSOKAWA KAZUYA; NAGATA MASANORI 权利人:FUJIMORI KOGYO CO 摘要:A method for a synthesis of anhydrothrombin is provided which features a short process, an easy procedure, and high yields. n The method comprises n (A) a step of causing an active serine residue site of thrombin to react with an inhibitor, n (B) a step of performing an alkali treatment at a pH of not less than 11, and n (C) a step of performing an operation of recovery, and carries out these steps sequentially in the order mentioned, and is characterized by causing at least the step of performing the operation of recovery to proceed in the presence of at least one compound selected from the group consisting of polyhydric alcohols and saccharides, and a salt or an amphoteric electrolyte.
专利号:US-7498434-B2 优先权日:2004-01-14 标题:Two-phase method for the synthesis of selected pyrazolopyrimidines 发明人:CANTRELL GARY LEE; MOSER FRANK WILLIAM; HALVACHS ROBERT EDWARD 权利人:MALLINCKRODT INC 摘要:An improved method of making a substituted pyrazolopyrimidine. The method comprises reacting a aminopyrazole compound or a salt thereof with a substituted 1-oxo-2-propenyl-arene(-heterocycle) or a salt thereof under acidic conditions in a reaction medium including a two-phase mixture of an aqueous solution and a water-immiscible organic liquid. Specific substituted pyrazolopyrimidines include N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide and N-methyl-N-(3-{3-[2-thienyl-carbonyl]-pyrazolo[1,5-a]-pyrimidin-7-yl}phenyl)acetamide.
专利号:US-8048647-B2 优先权日:2004-06-07 标题 :Aldolase, and method for producing optically active IHOG and monatin 发明人:SUGIYAMA MASAKAZU; WATANABE KUNIHIKO; MORI KENICHI; NOZAKI HIROYUKI 权利人:AJINOMOTO KK 摘要:The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and aldolase used for these methods. As such, the present invention enables the synthesis of 4-(Indole-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid with high optical purity, which is useful as an intermediate in the synthesis of optically active monatin, from indole pyruvic acid and pyruvic acid (or oxaloacetic acid).
专利号:US-8697416-B2 优先权日:2002-08-26 标 题:Recombinant polynucleotide, host cells containing the same and a process for producing a protein having aldolase activity 发明人:SUGIYAMA MASAKAZU; WATANABE KUNIHIKO; KAWAHARA SHIGERU 权利人:SUGIYAMA MASAKAZU; WATANABE KUNIHIKO; KAWAHARA SHIGERU; AJINOMOTO KK 摘要:4-(Indol-3-ylmethyl)-4-hydroxy-2-oxoglutarate, which is useful as an intermediate in the synthesis of monatin, may be synthesized from indole pyruvic acid and pyruvic acid (and/or oxaloacetic acid) by using a novel aldolase derived from the genus Pseudomonas, Erwinia, Flavobacterium , or Xanthomonas.
专利号:AU-2004314335-A1 优先权日:2004-01-14 标题 :Two-phase method for the synthesis of selected pyrazolopyrimidines