CAS: 151169-75-4; 3,4-Dichlorophenylboronic Acid

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401797-02-2 862248-93-9 63503-60-6

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CAS号18282-59-2 3,4-二氯溴苯 | CAS号10294-33-4 三溴化硼 | CAS号32598-13-3 3,3',4,4'-四氯联苯 | CAS号2039-83-0 3,4-二氯苯乙烯 | CAS号31508-00-6 2,3',4,4',5-五氯联苯标准溶液 | CAS号32598-10-0 2,3',4,4'-四氯联苯 | CAS号401797-02-2 3.4-二氯苯硼酸频呢醇酯 | CAS号32598-11-1 2,3,4,5-四氯联苯醚 | CAS号41464-43-1 2,3,3'4'-四氯联苯 | CAS号38444-86-9 2',3,4-三氯联苯 | CAS号79617-96-2 舍曲林 | CAS号854892-34-5 CYCLOHEXYL 3,4-...

3,4-二氯溴苯置于正丁基锂,硼酸三甲酯体系中,用 四氢呋喃 用作溶剂,化学反应生成3,4-二氯苯硼酸
参考文献:氢化铜催化还原反应合成1,1-二芳基烷基单元的不对称性:两个相似的芳基取代基之间的区别
标题:氢化铜催化还原反应合成1,1-二芳基烷基单元的不对称性:两个相似的芳基取代基之间的区别
摘要:已开发出一种有效的方法来制备对映体富集的1,1-二芳基烷基单元.氢化铜与(R)-1 [[(S)-2-二苯基膦基)二茂铁基]乙基二环己基膦(josiphos)配位体的络合可实现β,β-二芳基取代的α,β-不饱和腈的高度对映体选择性共轭还原具有类似空间需求的芳基,并且没有二级配位点.减少了在芳基上具有间位和对位取代基的一系列底物,对映选择性很好(至97%对映体过量(ee)),并且该方法学被用于indatraline的正式合成.
Doi:10.1002/chem.200901262

专利信息

专利号:US-2008119524-A1
优先权日:2002-08-14
标题 :Prenylation inhibitors containing dimethylcyclobutane and methods of their synthesis and use
发明人：BROWN BRADLEY B; REHDER KENNETH S; STRACHAN JON-PAUL; EAVES JERON H; LOWDEN CHRISTOPHER T
权利人:BROWN BRADLEY B; REHDER KENNETH S; STRACHAN JON-PAUL; EAVES JERON H; LOWDEN CHRISTOPHER T
摘要:The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.

专利号:US-11066447-B2
优先权日:2016-08-08
标 题:Aureobasidium derivatives and methods of synthesis
发明人：WUTS PETER; ELHAMMER AKE P
权利人:AUREOGEN BIOSCIENCES INC; AUEROGEN BIOSCIENCES INC
摘要:In general, the invention relates to AbA derivatives that are useful for treating infection. These novel compounds are shown to be effective in treating various fungal infections. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various fungal infections.

专利号:US-7166619-B2
优先权日:2002-08-14
标题 :Prenylation inhibitors and methods of their synthesis and use
发明人：LI FRANCINE FEIRONG; REHDER KENNETH S; CAMPBELL MICHAEL GORDON; VISCARDI CELESTE PATRICE; STRACHAN JON-PAUL; GUO ZHENGMING
权利人:PPD DISCOVERY INC
摘要:The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.

专利号:US-7501446-B2
优先权日:2002-08-14
标 题 :Prenylation inhibitors and methods of their synthesis and use
发明人：LI FRANCINE FEIRONG; REHDER KENNETH S; CAMPBELL MICHAEL GORDON; VISCARDI CELESTE PATRICE; STRACHAN JON-PAUL; GUO ZHENGMING
权利人:PPD DISCOVERY INC
摘要:The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.

专利号:EP-1238978-A2
优先权日:1999-05-12
标 题:Intermediates for the synthesis of radiolabelled tropanes

专利号:US-2005004122-A1
优先权日:2002-08-14
标题 :Prenylation inhibitors containing dimethylcyclobutane and methods of their synthesis and use