CAS: 14246-55-0; 2-Tetradecanamidoacetic Acid

相似化合物

142-58-5 2441-41-0 6333-54-6

上下游产品

myristyl chloride glycine sodium glycinate tetradecanoyl chloride2Myristoyl-Gly-Met-Arg-Pro-Tyr-Asp-Ala-Asn-Lys-Ala-NH2 2Myristoyl-Gly-Arg-Pro-Tyr-Asp-Ala-Asn-Lys-Arg-NH2 2Myristoyl-Gly-Pro-Tyr-Asp-Ala-Asn-Lys-Arg-NH2 2Myristoyl-Gly-Tyr-Asp-Ala-Asn-Lys-Arg-NH2

📜肉豆蔻酸置于sodium Hydroxide,三氯化磷体系中,用 水,丙酮 用作溶剂,化学反应 5.0H,反应生成N-(1-氧代十四烷基)-甘氨酸
参考文献:基于甘氨酸和丝氨酸的氨基酸表面活性剂的结构与性质的关系
标题:基于甘氨酸和丝氨酸的氨基酸表面活性剂的结构与性质的关系
摘要:用丙酸,辛酸,癸酸,十二烷酸,十四烷酸和十六烷酸合成了两种基于甘氨酸和丝氨酸的表面活性剂.用ms和1 H NMR对所有表面活性剂进行了表征,合成的表面活性剂的结构正确,可解释ms和1 H NMR中的信号.研究了反应条件,表面性质和泡沫性质.对于两个系列表面活性剂,临界胶束浓度(cmc)和γ Cmc(cmc处的表面张力)随着碳链长度的增加而降低,表面活性增强.具有十四烷酰基和十六烷酰基的表面活性剂显示出非常好的发泡性能,尤其是长链酰基丝氨酸的性能更好.这些都与丝氨酸中的氢甲基有关.
Doi:10.1007/s11743-012-1432-2

专利信息

专利号:WO-2024058717-A1
优先权日:2022-09-14
标题:Engineering of rhizomucor miehei lipase towards amide bond formation for the synthesis of medium to long chain n-acyl glycines in aqueous media
发明人：LI ZHI; KUA KAI BIN; NGUYEN KIEN TRUC GIANG
权利人:WILMAR INTERNATIONAL LTD; NAT UNIV SINGAPORE
摘要:Described herein are lipase variants of a Rhizomucor Miehei Lipase. The lipase variants may be used to prepare medium to long chain N-acyl glcyines. The variants may have a parent sequence of SEQ ID NO: 3; and a D156 substitution and/or a L258 substitution, wherein the D156 substitution is selected from the group consisting of serine (S), glycine (G), glutamic acid (E), and threonine (T), wherein if the D156 substitution is glycine, the lipase variant comprises at least one other substitution, and the L258 substitution is selected from the group consisting of lysine (K), arginine (R), glutamine (Q), asparagine (N), histidine (H), and serine (S). The variants may have a parent sequence of SEQ ID NO: 3; and at least one substitution of the following amino acids: D156, L258. L267, V254, L255, N264, T265, S83, S84, W88, R30, R86, S56, L58, and 1I59.

专利号:US-9567368-B2
优先权日:2013-11-29
标 题:Peptide tyrosinase activators
发明人：HANTASH BASIL M; UBEID ANAN ABU
权利人:ESCAPE THERAPEUTICS INC
摘要:Peptides that increase melanin synthesis are provided. These peptides include pentapeptides YSSWY (SEQ ID NO: 1), YRSRK (SEQ ID NO: 2), and their variants. The peptides may activate the enzymatic activity of tyrosinase to increase melanin synthesis. The pharmaceutical, cosmetic, and other compositions including the peptides are also provided. The methods of increasing melanin production in epidermis of a subject are provided where the methods include administering compositions comprising an amount of one or more peptides effective to increase the melanin production. The methods also include treating vitiligo or other hypopigmentation disorders with compositions including one or more peptides.

专利号:CN-117003667-A
优先权日:2023-07-05
标题:Design, synthesis and application of a class of N-alkanoylglycine homologues that can be used in retention index systems