专利号:WO-2024199310-A1 优先权日:2023-03-31 标 题 :Method for enzymatic synthesis of capped mrna in one tube 发明人:LI YALI; ZHU HUAXING; ZHANG QINGYI 权利人:NOVOPROTEIN SCIENT INC 摘要:Provided is a method for enzymatic synthesis of capped mRNA in one tube. In the method, the step of purifying mRNA after IVT is omitted, and a capped product having a higher capping efficiency and fewer by-products is obtained. The method provided for enzymatic synthesis of capped mRNA is simple, convenient and short in terms of the process, and is rapid and efficient, so that the production process of a capped mRNA product is simplified, and a production cost is reduced, which is conducive to industrial production.
专利号:US-6329543-B1 优先权日:1999-05-06 标题:Process for synthesis of isobornyl (Meth) acrylate 发明人:KNEBEL JOACHIM; SAAL DORIS 权利人:ROEHM GMBH 摘要:The present invention relates to processes for synthesis of isobornyl (meth)acrylate by reacting camphene with (meth)acrylic acid in the presence of sulfuric acid and at least one compound having inhibiting action. Aqueous sulfuric acid with an acid concentration in the range of 65 to 85 wt % is used. Isobornyl (meth)acrylate can advantageously be distilled from a mixture containing sulfuric acid in the presence of 2,6-di-tert-butyl-alpha-(dialkylamino)-p-cresol.
专利号:US-2024309142-A1 优先权日:2023-03-17 标题 :Capped block copolymers, their synthesis, manufacture, and methods of use 发明人:MAN VICTOR FUK-PONG; LI XIAOJIN HARRY; CHEN YIQING; PU GANG; HUNT JR CLINTON 权利人:ECOLAB USA INC 摘要:This disclosure relates to capped block copolymers, preferably reverse block copolymers capped with a hydrophobic group. Preferred hydrophobic groups include benzyl groups and silyl groups. In a preferred embodiment, the reverse block copolymer has at least two arms, wherein each arm is capped with a hydrophobic group. The disclosure also provides for the synthesis of the capped block copolymers as well as methods of using the capped block copolymers for defoaming and antifoaming applications.
专利号:US-3683014-A 优先权日:1970-10-14 标题:Derivatives of 2-amino-3-sulfopropionic acid 发明人:YANG MEILING T 权利人:ETHYL CORP 摘要:To obviate eutrophication of water, non-phosphorus detergent builders are provided. These are the water-soluble salts of 2-(N, N-di-(carboxymethyl))amino-3-sulfopropionic acid (e.g., the tetrasodium salt thereof). Conventional detergent actives may be used with these builders. Synthesis of the builders is described.
专利号:US-7205385-B2 优先权日:2004-11-12 标 题:Polymerization method for the synthesis of polypeptide imaging agents 发明人:GRIMMOND BRIAN JAMES; MOASSER BAHRAM; AMARATUNGA MOHAN MARK 权利人:GEN ELECTRIC 摘要:A method for synthesizing extended poly(amino acids) conjugated to imaging agents, such as DTPA, is disclosed. The amino acid is initially conjugated to the imaging agent at the monomer stage, followed by formation of the corresponding N-carboxyanhydride. The method utilizes catalyzed ring opening polymerization of the N-carboxyanhydride of the amino acid-imaging agent monomer allowing the formation of a poly(amino acid) backbone having 100% imaging agent conjugation if desired. However, the present method also permits the degree of conjugation to be controlled by copolymerizing the N-carboxyanhydride of the amino acid-imaging agent monomer with one or more unconjugated monomers, i.e. N-carboxyanhydrides of the same or of other amino acids. Various imaging agents may be employed, and new hybrid random, block, and mixed copolymers may be prepared.
专利号:US-9603928-B2 优先权日:2013-06-19 标题:Medicinal composition for promoting synthesis of protoporphyrin IX 发明人:ISHIZUKA MASAHIRO; OTO URARA; KAMIYA ATSUKO; TAKAHASHI KIWAMU; TANAKA TOHRU; OZAWA TOSHIYUKI; MORIMOTO KUNIYUKI; WATANABE KEITARO 权利人:SBI PHARMACEUTICALS CO LTD; UNIV OSAKA CITY 摘要:The object of the present invention is to elucidate the resistance mechanism in infections that show resistance to ALA-PDT that uses a single ALA, and to provide a novel treatment method against these infections. The present invention provides a pharmaceutical composition for promoting protoporphyrin IX production in ALA-PDT for treating infection, characterized in that it comprises a substance that promotes the conversion from coproporphyrinogen III to protoporphyrin IX.
[参考文献]: Eitaro Aihara, Et Al. In Vivo Epithelial Wound Repair Requires Mobilization Of Endogenous Intracellular And Extracellular Calcium. J Biol Chem. 2013 Nov 22;288(47):33585-33597. [参考文献]: Jose M Alvarez, Et Al. Influence Of Soil Type On The Mobility And Bioavailability Of Chelated Zinc. J Agric Food Chem. 2007 May 2;55(9):3568-76. [参考文献]: L Lemonnier, Et Al. Direct Modulation Of Volume-Regulated Anion Channels By Ca(2+) Chelating Agents. Febs Lett. 2002 Jun 19;521(1-3):152-6. [参考文献]: L Q Lou, Et Al. Solubility And Accumulation Of Metals In Chinese Brake Fern, Vetiver And Rostrate Sesbania Using Chelating Agents. Int J Phytoremediation. 2007 Jul-Aug;9(4):325-43. [参考文献]: Mohamed M Shoukry, Et Al. Equilibrium, Kinetic And Solvent Effect Studies On The Reactions Of [ruiii(Hedta)(H2O)] With Thiols. Dalton Trans. 2005 Dec 21:(24):3921-6.
合成参考文献
摘要:Compound: Glycine, N-[2-[bis(carboxymethyl)amino]ethyl]-N-(2-hydroxyethyl)-, sodium salt (1:2) 摘要:Compound: N-(Hydroxyethyl)ethylenediamine-N,N′,N′-triacetic acid monosodium salt