专利号:US-5455157-A 优先权日:1989-05-22 标 题:Method for the non-radioactive measurement of the nucleic acid synthesis in eukaryotic cells 发明人:HINZPETER MATTHIAS; ELTZ HERBERT VON DER 权利人:BOEHRINGER MANNHEIM GMBH 摘要:For the determination of the rate of nucleic acid synthesis in eukaryotic cells a nucleotide which is non-radioactively labelled or derivatized with a hapten is introduced into the cells with the addition of liposomes and the rate of synthesis of the nucleic acids is determined by means of the incorporation of the nucleotide via its label or derivatization.
专利号:US-7829124-B2 优先权日:2001-04-26 标题:Use of Phyllanthus constituents for treating or preventing infections caused by hepatitis B-viruses 发明人:OTT MICHAEL; MANNS MICHAEL P 权利人:OTT MICHAEL; MANNS MICHAEL P 摘要:The disclosure relates to a method of inhibiting synthesis of viral DNA in a mammal infected with a hepatitis B virus. This method includes administering at least one Phyllanthus component or substance to a mammal infected with the hepatitis B virus. It also includes inhibiting hepatitis B viral DNA synthesis in the mammal using the Phyllanthus component or substance. The disclosure also relates to a method of inhibiting viral gene expression in a mammal infected with a hepatitis B virus. This method includes administering at least one Phyllanthus component or substance to a mammal infected with the hepatitis B virus. It also includes inhibiting expression of at least one hepatitis B viral gene in the mammal using the Phyllanthus component or substance. These methods may form part of a method of preventing or treating hepatitis B infection.
专利号:US-2018317484-A1 优先权日:2017-05-07 标题:Composition for inhibiting synthesis of mycotoxin without affecting the growth of the fungi 发明人:MEHTA ALKA; BOGA RAMESHBABU; P DHANAMJAYULU 权利人:VIT UNIV; BogaR Laboratories 摘要:A composition for inhibiting the growth of mycotoxins without affecting the growth of fungi is provided. The mycotoxin is an Aflatoxin and the fungus is an Aspergillus . The anti-aflatoxin composition comprises benzimidazole derivatives of Formula, n n n n n n n n n n where the A is hydrogen or C1-C6 alkyl or C6-C14 aryl; B is C1-C10 alkyl or C6-C14 aryl or oxygen, sulfur, nitrogen containing heteroaryl; C and D are hydrogen or C1-C6 alkyl or C1-C6 alkoxyl or C6-C14 aryl; E is hydrogen or nitro or cyano or carboxyl or acetamidoxime or amidoxime or C1-C6 alkyl or C1-C6 alkoxyl or C6-C14 aryl or oxygen, sulfur, and nitrogen containing heteroaryl; F is hydrogen or C1-C6 alkyl or C1-C6 alkoxyl or C6-C14 aryl or oxygen, sulfur, and nitrogen containing heteroaryl, and mixture thereof with corresponding salts.
专利号:US-5662898-A 优先权日:1990-08-20 标 题 :Genes for the synthesis of antipathogenic substances 发明人:LIGON JAMES M; HILL DWIGHT STEVEN; LAM STEPHEN TING; HAMMER PHILIP E 权利人:CIBA GEIGY CORP 摘要:The present invention is directed to the production of an antipathogenic substance (APS) in a host via recombinant expression of the polypeptides needed to biologically synthesize the APS. Genes encoding polypeptides necessary to produce particular antipathogenic substances are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize any desired APS. The cloned genes may be transformed and expressed in a desired host organisms to produce the APS according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of the APS.
专利号:US-2009181379-A1 优先权日:2005-09-29 标 题 :Molecular markers of hepatocellular carcinoma and their applications 发明人:CORRALES IZQUIERDO FERNANDO; SANTAMARIA MARTINEZ ENRIQUE; MUNOZ PERALTA JAVIER; PRIETO VALTUENA JESUS; AVILA ZARAGOZA MATIAS 权利人:PROYECTO BIOMEDICINA CIMA SL 摘要:By means of a proteomic approach, the markers of hepatocellular carcinoma (HCC) in the liver of a knockout mouse (MAT1A−/−) have been identified for the MAT1A gene (deficient in the synthesis of S-adenosylmethionine). 27 proteins have been detected the expression thereof is altered in, at least, 50% of the analysed tumours. Amongst them, 13 proteins have been validated in biopsies of patients with HCC of different etiology, and 7 of them have been validated in biopsies of patients with liver cirrhosis, a stage prior to the development of HCC, which makes it possible to differentiate between prior stages of the disease and even between different etiologies (viral and alcoholic). Having a panel of markers available may contribute to more accurately defining the alterations associated with the development of HCC and thus facilitate prognosis and diagnosis of this disease.
专利号:US-2018333433-A1 优先权日:2017-05-18 标题 :Synthesis of silver nanoparticles using sesame oil cake 发明人:ALSALHI MOHAMAD SALEH; DEVANESAN SANDHANASAMY; ALFURAYDI AKRAM AHMED; AL-ANSARI MYSOON M F 权利人:UNIV KING SAUD 摘要:A method of synthesizing silver nanoparticles includes using sesame ( Sesamum indicum ) oil cake extract as a reducing agent. The silver nanoparticles can range in size from about 6 nm to about 15 nm. The silver nanoparticles can have an average particle size of about 10 nm.
摘要:Tabata S et al; J AOAC Internatl 76: 32-5 (1993) 摘要:Teichman B, Krug G; Arch Geschwulstforsch 45 (1): 25 (1975) 摘要:Full text: 摘要:Cole, R. J. and R. H. Cox. Handbook of Toxic Fungal Metabolites. New York: Academic Press, Inc., 1981., p. 25 摘要:US EPA; Estimation Program Interface (EPI) Suite. Ver. 4.1. Nov, 2012. Available from, as of Jun 19, 2013: https://www.epa.gov/oppt/exposure/pubs/episuitedl.htm