CAS: 1165-39-5; Aflatoxin G1

该化合物是某些霉素,特别是Aspergillus flavus 和 Aspergilus moniticus 所产的天然的蛋白毒素,被归类为强致癌物质,已知它对人体和动物都有毒性影响.黄曲霉毒素G1是一组黄曲霉毒素的一部分,它会污染农产品,特别是谷物,坚果和种子,导致摄取时出现严重的健康风险.该化合物的特点是其结构复杂,包括一个双环系统和各种功能组,有助于其生物活动.黄曲毒素G1在有机溶剂中可溶解,但水溶性有限,影响其在生物系统和环境环境中的行为.由于其毒性,监管机构监测食品中的黄曲毒素水平,并采取措施尽量减少污染.在食品中存在黄曲G1可能会导致严重的健康问题,包括肝脏损害和癌症风险增加,从而使其在食品安全和公共卫生中引起重大关注.

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1aflatoxin B1 2aflatoxin G2

合成工艺路线路线简述

    📜黄曲霉毒素 B1 反应生成黄曲霉素 G1
    参考文献:Lai,F. Y.;Dimson,P.;Wehr,C. T.,Pittsburgh Conf. And Expo. Anal. Chem. And Appl. Spectrosc.,New Orleans,+
    标题:Lai,F. Y.;Dimson,P.;Wehr,C. T.,Pittsburgh Conf. And Expo. Anal. Chem. And Appl. Spectrosc.,New Orleans,+

    海关参考信息

    专利信息


    专利号:US-5455157-A
    优先权日:1989-05-22
    标 题:Method for the non-radioactive measurement of the nucleic acid synthesis in eukaryotic cells
    发明人:HINZPETER MATTHIAS; ELTZ HERBERT VON DER
    权利人:BOEHRINGER MANNHEIM GMBH
    摘要:For the determination of the rate of nucleic acid synthesis in eukaryotic cells a nucleotide which is non-radioactively labelled or derivatized with a hapten is introduced into the cells with the addition of liposomes and the rate of synthesis of the nucleic acids is determined by means of the incorporation of the nucleotide via its label or derivatization.

    专利号:US-7829124-B2
    优先权日:2001-04-26
    标题:Use of Phyllanthus constituents for treating or preventing infections caused by hepatitis B-viruses
    发明人:OTT MICHAEL; MANNS MICHAEL P
    权利人:OTT MICHAEL; MANNS MICHAEL P
    摘要:The disclosure relates to a method of inhibiting synthesis of viral DNA in a mammal infected with a hepatitis B virus. This method includes administering at least one Phyllanthus component or substance to a mammal infected with the hepatitis B virus. It also includes inhibiting hepatitis B viral DNA synthesis in the mammal using the Phyllanthus component or substance. The disclosure also relates to a method of inhibiting viral gene expression in a mammal infected with a hepatitis B virus. This method includes administering at least one Phyllanthus component or substance to a mammal infected with the hepatitis B virus. It also includes inhibiting expression of at least one hepatitis B viral gene in the mammal using the Phyllanthus component or substance. These methods may form part of a method of preventing or treating hepatitis B infection.

    专利号:US-2018317484-A1
    优先权日:2017-05-07
    标题:Composition for inhibiting synthesis of mycotoxin without affecting the growth of the fungi
    发明人:MEHTA ALKA; BOGA RAMESHBABU; P DHANAMJAYULU
    权利人:VIT UNIV; BogaR Laboratories
    摘要:A composition for inhibiting the growth of mycotoxins without affecting the growth of fungi is provided. The mycotoxin is an Aflatoxin and the fungus is an Aspergillus . The anti-aflatoxin composition comprises benzimidazole derivatives of Formula, n n n n n n n n n n where the A is hydrogen or C1-C6 alkyl or C6-C14 aryl; B is C1-C10 alkyl or C6-C14 aryl or oxygen, sulfur, nitrogen containing heteroaryl; C and D are hydrogen or C1-C6 alkyl or C1-C6 alkoxyl or C6-C14 aryl; E is hydrogen or nitro or cyano or carboxyl or acetamidoxime or amidoxime or C1-C6 alkyl or C1-C6 alkoxyl or C6-C14 aryl or oxygen, sulfur, and nitrogen containing heteroaryl; F is hydrogen or C1-C6 alkyl or C1-C6 alkoxyl or C6-C14 aryl or oxygen, sulfur, and nitrogen containing heteroaryl, and mixture thereof with corresponding salts.

    专利号:US-5662898-A
    优先权日:1990-08-20
    标 题 :Genes for the synthesis of antipathogenic substances
    发明人:LIGON JAMES M; HILL DWIGHT STEVEN; LAM STEPHEN TING; HAMMER PHILIP E
    权利人:CIBA GEIGY CORP
    摘要:The present invention is directed to the production of an antipathogenic substance (APS) in a host via recombinant expression of the polypeptides needed to biologically synthesize the APS. Genes encoding polypeptides necessary to produce particular antipathogenic substances are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize any desired APS. The cloned genes may be transformed and expressed in a desired host organisms to produce the APS according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of the APS.

    专利号:US-2009181379-A1
    优先权日:2005-09-29
    标 题 :Molecular markers of hepatocellular carcinoma and their applications
    发明人:CORRALES IZQUIERDO FERNANDO; SANTAMARIA MARTINEZ ENRIQUE; MUNOZ PERALTA JAVIER; PRIETO VALTUENA JESUS; AVILA ZARAGOZA MATIAS
    权利人:PROYECTO BIOMEDICINA CIMA SL
    摘要:By means of a proteomic approach, the markers of hepatocellular carcinoma (HCC) in the liver of a knockout mouse (MAT1A−/−) have been identified for the MAT1A gene (deficient in the synthesis of S-adenosylmethionine). 27 proteins have been detected the expression thereof is altered in, at least, 50% of the analysed tumours. Amongst them, 13 proteins have been validated in biopsies of patients with HCC of different etiology, and 7 of them have been validated in biopsies of patients with liver cirrhosis, a stage prior to the development of HCC, which makes it possible to differentiate between prior stages of the disease and even between different etiologies (viral and alcoholic). Having a panel of markers available may contribute to more accurately defining the alterations associated with the development of HCC and thus facilitate prognosis and diagnosis of this disease.

    专利号:US-2018333433-A1
    优先权日:2017-05-18
    标题 :Synthesis of silver nanoparticles using sesame oil cake
    发明人:ALSALHI MOHAMAD SALEH; DEVANESAN SANDHANASAMY; ALFURAYDI AKRAM AHMED; AL-ANSARI MYSOON M F
    权利人:UNIV KING SAUD
    摘要:A method of synthesizing silver nanoparticles includes using sesame ( Sesamum indicum ) oil cake extract as a reducing agent. The silver nanoparticles can range in size from about 6 nm to about 15 nm. The silver nanoparticles can have an average particle size of about 10 nm.

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    合成参考文献


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    摘要:Full text:
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    摘要:US EPA; Estimation Program Interface (EPI) Suite. Ver. 4.1. Nov, 2012. Available from, as of Jun 19, 2013: https://www.epa.gov/oppt/exposure/pubs/episuitedl.htm
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