CAS: 114058-79-6; 4-Methylquinolin-7-Amine
该化合物是一种有机化合物,其特征为quinoline结构,由含有氮原子的双环芳香系统组成;该化合物的特征为7位置的氨基化合物(-NH2)和4位置的甲基混合物(-CH3),在Qinnoline环的4位置的氨基化合物;该物质一般在室温下是固体的,可能根据具体情况表现出有机溶剂溶解性和水溶性有限等特性;氨基化合物的存在表明其潜在的基本性和再活动性,允许其参与各种化学反应,包括核循环替代和组合反应;此外,该类别化合物可能展示生物活动,使其对药用化学和药物开发感兴趣;处理和接触准则应参考安全数据,如同任何化学物质一样.
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580-19-8 64334-96-9 62748-01-0物理性质
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- 合成目标产物 7-Quinolinamine,4-Methyl-(9CI) 主要起始原料 M-Phenylenediamine
- (文献来源)合成步骤主要原料 M-Phenylenediamine
📜间苯二胺置于palladium On Activated Charcoal 氢气,三氯氧磷体系中,用 溶剂黄146 用作溶剂,化学反应 1.0H,反应生成4-甲基-7-喹啉胺
参考文献:7-Aminoquinolines. A Novel Class Of Agents Active Against Herpes Viruses
标题:7-Aminoquinolines. A Novel Class Of Agents Active Against Herpes Viruses
摘要:A Series Of 7-Aminoquinoline Derivatives Was Synthesized And Evaluated For Their Capacity To Produce Cytotoxicity In Kb Cells And To Inhibit The Replication Of Herpes Simplex Virus (Hsv) Type 1. All Compounds Tested Inhibited The Replication Of Hsv-1 With 50% Inhibitory Concentrations In The Range Of 2-50 Micrograms/ml. The Antiviral Activity Of Many Compounds,However,Was Separated From Cytotoxicity To Replicating Uninfected Cells By Only Two-To Fivefold Higher Than Those Required For Antiviral Activity. Nonetheless,Six Compounds (10,28,29,32,34,And 36) Were Identified In Which The Separation Was Greater Than Fivefold. All Compounds Examined Were More Potent Inhibitors Of Viral Dna Synthesis Than The Cellular Dna Synthesis.
Doi:10.1021/jm00402A016
海关参考信息
- 2933310010-吡啶
2939800000-其他生物碱 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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合成参考文献
参考文献:10.1021/jm00402a016
摘要:Nasr M, Drach JC, Smith SH, Shipman C, Burckhalter JH. 7-Aminoquinolines. A novel class of agents active against herpesviruses. J Med Chem. 1988 Jul;31(7):1347–51. doi: 10.1021/jm00402a016.
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