CAS: 106921-60-2; 2,2-Dimethyl-3-Oxopentanal

相似化合物

1118-71-4 3142-58-3 37719-03-2

📜(+/-)-4,4-Dimethylhex-5-En-3-Ol置于戴斯-马丁氧化剂,臭氧体系中,用 甲醇,二氯甲烷 用作溶剂,化学反应 6.0H,反应生成2,2-二甲基-3-氧代戊醛
参考文献:通过有机硼烷合成埃博霉素a的研究.
标题:通过有机硼烷合成埃博霉素a的研究.
摘要:已经描述了通过有机硼烷合成埃坡霉素a的研究.已开发出一种从异戊烯醇大规模制备b-γ,γ-二甲基烯丙基亚砜基樟脑基硼烷的改进方法.与各种醛反应后,该试剂以高对映选择性提供相应的α,α-二甲基均烯丙基醇.已经证明了该试剂在合成埃博霉素的c1-C6亚基中的应用.或者,分子间和分子内不对称还原方案也已用于合成埃坡霉素a的c1-C6亚基.使用α-Pine烯衍生的试剂合成埃坡霉素a的c7-C21片段,涉及不对称烷氧基烯丙基和巴豆基硼化也已经描述过了.
Doi:10.1039/b508001K

专利信息

专利号:US-6350878-B1
优先权日:1998-05-18
标 题 :Intermediates for the synthesis of epothilones and methods for their preparation
发明人：ALTMANN KARL-HEINZ; BAUER ARMIN; SCHINZER DIETER
权利人:NOVARTIS AG
摘要:The invention relates to a method of synthesis for a compound of formula (I),wherein R is a heterocyclyl moiety and X1, X2, X3 and X4 are, independently of each other, protecting groups, which is appropriate for the synthesis of epothilone B and desoxyepothione B.

专利号:US-2003176368-A1
优先权日:2001-09-06
标题:Synthesis of epothilones, intermediates thereto and analogues thereof
发明人：DANISHEFSKY SAMUEL J; BISWAS KAUSTAV; CHAPPELL MARK; LIN HONG; NJARDARSON JON T; LEE CHUL BOM; RIVKIN ALEXY; CHOU TING-CHAO
摘要:The present invention provides compounds of formula (I): n n n as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).

专利号:US-2002058286-A1
优先权日:1999-02-24
标 题 :Synthesis of epothilones, intermediates thereto and analogues thereof
发明人：DANISHEFSKY SAMUEL J; STACHEL SHAWN J; LEE CHUL BOM; CHAPPELL MARK D; CHOU TING-CHAO; WU ZHICAI
摘要:The present invention provides convergent processes for preparing epothilones, desoxyepothilones, and analogues thereof. The present invention further provides novel compositions and methods for the treatment of cancer and additionally provides methods for the treatment of cancer which has developed a multi-drug phenotype.

专利号:US-6867305-B2
优先权日:1996-12-03
标题:Synthesis of epothilones, intermediates thereto and analogues thereof
发明人：DANISHEFSKY SAMUEL J; STACHEL SHAWN J; LEE CHUL BOM; CHAPPELL MARK D; WU ZHICAL
权利人:SLOAN KETTERING INST CANCER; UNIV COLUMBIA
摘要:The present invention provides convergent processes for preparing epothilones, desoxyepothilones, and analogues thereof. The present invention further provides novel compositions and methods for the treatment of cancer and additionally provides methods for the treatment of cancer which has developed a multi-drug phenotype.

专利号:US-6867333-B2
优先权日:2000-10-16
标题:Epothilone synthesis building blocks iii and iv: asymmetrically substituted acyloins and acyloin derivatives, methods for their production and methods for the production of epothilones b, d and epothilone derivatives
发明人：WESSJOHANN LUDGER A; SCHEID GUNTHER; BORNSCHEUER UWE; HENKE ERIK; KUIT WOUTER; ORRU ROMANO
权利人:MORPHOCHEM AG
摘要:The present invention is directed to novel acyloins, their derivatives, methods for their production and their use for the production of novel epothilones and their derivatives. In addition, the invention is directed to the building blocks for epothilone synthesis, methods for their production and the use of synthetic building blocks for the production of epothilones and their derivatives.

专利号:WO-9959985-A1
优先权日:1998-05-18
标题:Intermediates for the synthesis of epothilones and methods for their preparation