CAS: 88107-10-2; Tomelukast
该化合物是一种主要用于治疗哮喘和过敏鼻膜炎的血水受体对抗剂,其作用是抑制作为煽动性调解器的脑炎分子的行动,这种行动有助于肠道收缩和肌肉生产;Tomelukast通常通过口服,以其有利的药用植物基因特征为名,包括口服生物利用率高和相对长的半衰期,允许每天服一次药;该物质的特点在于其能够减少气道炎,改善肺功能,使呼吸道病人成为宝贵的治疗选择;此外,它一般是良好的,副作用可能包括轻微的胃肠紊乱或头痛;与任何药物一样,病人必须咨询保健专业人员,以获得个人咨询,并讨论与其他药物的潜在互动.总的来说,Tmelukast是治疗哮喘和过敏症的重要进展.
- 英文名称Tomelukast
- 中文名称油酸三乙醇胺
- IUPAC名称Ethanone, 1-(2-hydroxy-3-propyl-4-(4-(1H-tetrazol-5-yl)butoxy)phenyl)-
- 其它别名Ethanone,1-[2-hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl]- (9CI); Tomelukast
- CAS编号88107-10-2
- MFCD编号:MFCD00211057
- EINECS号:635-828-7
- FDA UNII编号:59762X5CLS
- 分子式:C16H22N4O3分子量:318.37
- 产品CID: 1890208
- 产品分类表面活性剂 → 阴离子表面活性剂 → 其他阴离子表面活性剂
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报上下游产品
CAS号7440-44-0 活性炭合成工艺路线路线简述
- 92518-07-5 = 88107-10-2
反应条件:1.1 Reagents: Sodium Azide Catalysts: Triethylamine,Hydrochloride Solvents: N-Methyl-2-Pyrrolidone
标题:Improved Conditions For The Formation Of Tetrazoles
作者:Bernstein,P. R.; Vacek,E. P.
参考文献:Synthesis 日期:1987 卷标:(12) 页码:1033-4]
92518-07-5 = 88107-10-2
反应条件:1.1 Reagents: Ammonium Chloride,Sodium Azide Solvents: Dimethylformamide
标题:Leukotriene Receptor Antagonists. 1. Synthesis And Structure-Activity Relationships Of Alkoxyacetophenone Derivatives
作者:Marshall,Winston S.; Goodson,Theodore; Cullinan,George J.; Swanson-Bean,Dorothy; Haisch,Klaus D.; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:1987 卷标:30(4) 页码:682-9]
92518-07-5 = 88107-10-2
反应条件:1.1 Reagents: Sodium Azide
标题:Leukotriene Antagonists
参考文献:European Patent Organization
📜4-(4-Cyanobutoxy)-2-Hydroxy-3-Propylacetophenone置于sodium Azide,三乙胺盐酸盐体系中,用 Various Solvent(S) 作为反应溶剂,化学反应 3.0H,以76%的收率获得产物油酸三乙醇胺
参考文献:Improved Conditions For The Formation Of Tetrazoles
标题:Improved Conditions For The Formation Of Tetrazoles
摘要:四唑可以由腈和叠氮化钠在较短时间内以更高产率制备,所用催化剂为氯化三乙基铵,溶剂为1-甲基-2-吡咯烷酮.
DOI:10.1055/s-1987-28199
海关参考信息
- 2902600000-乙苯
2905121000-正丙醇
2905130000-正丁醇
2907221000-对苯二酚 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.
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品牌试剂参考报价(招募中)
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主要参考文献
1: Moreno JJ. Eicosanoid receptors: Targets for the treatment of disrupted intestinal epithelial homeostasis. Eur J Pharmacol. 2016 Dec 7;796:7-19. doi: 10.1016/j.ejphar.2016.12.004. [Epub ahead of print] Review.
4: Xu Y, Kong J, Hu P. Computational Drug Repurposing for Alzheimer's Disease Using Risk Genes From GWAS and Single-Cell RNA Sequencing Studies. Front Pharmacol. 2021 Jun 30;12:617537. doi: 10.3389/fphar.2021.617537.
合成参考文献
摘要:Fundamental and Applied Toxicology., 10(672), 1988
参考文献:10.1007/bf00124498
摘要:Hariprasad V, Kulkarni VM. A proposed common spatial pharmacophore and the corresponding active conformations of some peptide leukotriene receptor antagonists. Journal of Computer-Aided Molecular Design. 1996 Aug;10(4):284–92. doi: 10.1007/bf00124498.
参考文献:10.1016/s0022-3565(25)23959-3
摘要:Cook JA, Wise WC, Halushka PV. Protective effect of a selective leukotriene antagonist in endotoxemia in the rat. The Journal of Pharmacology and Experimental Therapeutics. 1985 Nov;235(2):470–4. doi: 10.1016/s0022-3565(25)23959-3.
参考文献:10.1007/bf00254925
摘要:Ball HA, Cook JA, Wise WC, Halushka PV. Role of thromboxane, prostaglandins and leukotrienes in endotoxic and septic shock. Intensive Care Med. 1986;12(3):116–26. doi: 10.1007/bf00254925.
参考文献:10.1007/bf00569663
摘要:Fleisch JH, Rinkema LE, Haisch KD, McCullough D, Patrick Carr F, Dillard RD. Evaluation of LY163443, 1-[2-hydroxy-3-propyl-4-{[4-(1H-tetrazol-5-ylmethyl)phenoxy]methyl}phenyl]ethanone, as a pharmacologic antagonist of leukotrienes D4 and E4. Naunyn-Schmiedeberg's Archives of Pharmacology. 1986 May;333(1):70–7. doi: 10.1007/bf00569663.
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